KEGG   Homo sapiens (human): 7075
Entry
7075              CDS       T01001                                 
Symbol
TIE1, JTK14, LMPHM11, TIE
Name
(RefSeq) tyrosine kinase with immunoglobulin like and EGF like domains 1
  KO
K05120  tyrosine kinase receptor 1 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Disease
H00535  Lymphatic malformation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7075 (TIE1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     7075 (TIE1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  TIE family
   7075 (TIE1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase fn3 ig Ig_DSCAM-DSCAML_C I-set Pur_ac_phosph_N Ig_3 EGF_2 hEGF Ig_2 EGF_PEAR1L C2-set Pkinase_fungal EGF_laminin Haspin_kinase DUF4702
Other DBs
NCBI-GeneID: 7075
NCBI-ProteinID: NP_005415
OMIM: 600222
HGNC: 11809
Ensembl: ENSG00000066056
UniProt: P35590
Structure
LinkDB
Position
1:43300982..43323108
AA seq 1138 aa
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
NT seq 3417 nt   +upstreamnt  +downstreamnt
atggtctggcgggtgccccctttcttgctccccatcctcttcttggcttctcatgtgggc
gcggcggtggacctgacgctgctggccaacctgcggctcacggacccccagcgcttcttc
ctgacttgcgtgtctggggaggccggggcggggaggggctcggacgcctggggcccgccc
ctgctgctggagaaggacgaccgtatcgtgcgcaccccgcccgggccacccctgcgcctg
gcgcgcaacggttcgcaccaggtcacgcttcgcggcttctccaagccctcggacctcgtg
ggcgtcttctcctgcgtgggcggtgctggggcgcggcgcacgcgcgtcatctacgtgcac
aacagccctggagcccacctgcttccagacaaggtcacacacactgtgaacaaaggtgac
accgctgtactttctgcacgtgtgcacaaggagaagcagacagacgtgatctggaagagc
aacggatcctacttctacaccctggactggcatgaagcccaggatgggcggttcctgctg
cagctcccaaatgtgcagccaccatcgagcggcatctacagtgccacttacctggaagcc
agccccctgggcagcgccttctttcggctcatcgtgcggggttgtggggctgggcgctgg
gggccaggctgtaccaaggagtgcccaggttgcctacatggaggtgtctgccacgaccat
gacggcgaatgtgtatgcccccctggcttcactggcacccgctgtgaacaggcctgcaga
gagggccgttttgggcagagctgccaggagcagtgcccaggcatatcaggctgccggggc
ctcaccttctgcctcccagacccctatggctgctcttgtggatctggctggagaggaagc
cagtgccaagaagcttgtgcccctggtcattttggggctgattgccgactccagtgccag
tgtcagaatggtggcacttgtgaccggttcagtggttgtgtctgcccctctgggtggcat
ggagtgcactgtgagaagtcagaccggatcccccagatcctcaacatggcctcagaactg
gagttcaacttagagacgatgccccggatcaactgtgcagctgcagggaaccccttcccc
gtgcggggcagcatagagctacgcaagccagacggcactgtgctcctgtccaccaaggcc
attgtggagccagagaagaccacagctgagttcgaggtgccccgcttggttcttgcggac
agtgggttctgggagtgccgtgtgtccacatctggcggccaagacagccggcgcttcaag
gtcaatgtgaaagtgccccccgtgcccctggctgcacctcggctcctgaccaagcagagc
cgccagcttgtggtctccccgctggtctcgttctctggggatggacccatctccactgtc
cgcctgcactaccggccccaggacagtaccatggactggtcgaccattgtggtggacccc
agtgagaacgtgacgttaatgaacctgaggccaaagacaggatacagtgttcgtgtgcag
ctgagccggccaggggaaggaggagagggggcctgggggcctcccaccctcatgaccaca
gactgtcctgagcctttgttgcagccgtggttggagggctggcatgtggaaggcactgac
cggctgcgagtgagctggtccttgcccttggtgcccgggccactggtgggcgacggtttc
ctgctgcgcctgtgggacgggacacgggggcaggagcggcgggagaacgtctcatccccc
caggcccgcactgccctcctgacgggactcacgcctggcacccactaccagctggatgtg
cagctctaccactgcaccctcctgggcccggcctcgccccctgcacacgtgcttctgccc
cccagtgggcctccagccccccgacacctccacgcccaggccctctcagactccgagatc
cagctgacatggaagcacccggaggctctgcctgggccaatatccaagtacgttgtggag
gtgcaggtggctgggggtgcaggagacccactgtggatagacgtggacaggcctgaggag
acaagcaccatcatccgtggcctcaacgccagcacgcgctacctcttccgcatgcgggcc
agcattcaggggctcggggactggagcaacacagtagaagagtccaccctgggcaacggg
ctgcaggctgagggcccagtccaagagagccgggcagctgaagagggcctggatcagcag
ctgatcctggcggtggtgggctccgtgtctgccacctgcctcaccatcctggctgccctt
ttaaccctggtgtgcatccgcagaagctgcctgcatcggagacgcaccttcacctaccag
tcaggctcgggcgaggagaccatcctgcagttcagctcagggaccttgacacttacccgg
cggccaaaactgcagcccgagcccctgagctacccagtgctagagtgggaggacatcacc
tttgaggacctcatcggggaggggaacttcggccaggtcatccgggccatgatcaagaag
gacgggctgaagatgaacgcagccatcaaaatgctgaaagagtatgcctctgaaaatgac
catcgtgactttgcgggagaactggaagttctgtgcaaattggggcatcaccccaacatc
atcaacctcctgggggcctgtaagaaccgaggttacttgtatatcgctattgaatatgcc
ccctacgggaacctgctagattttctgcggaaaagccgggtcctagagactgacccagct
tttgctcgagagcatgggacagcctctacccttagctcccggcagctgctgcgtttcgcc
agtgatgcggccaatggcatgcagtacctgagtgagaagcagttcatccacagggacctg
gctgcccggaatgtgctggtcggagagaacctagcctccaagattgcagacttcggcctt
tctcggggagaggaggtttatgtgaagaagacgatggggcgtctccctgtgcgctggatg
gccattgagtccctgaactacagtgtctataccaccaagagtgatgtctggtcctttgga
gtccttctttgggagatagtgagccttggaggtacaccctactgtggcatgacctgtgcc
gagctctatgaaaagctgccccagggctaccgcatggagcagcctcgaaactgtgacgat
gaagtgtacgagctgatgcgtcagtgctggcgggaccgtccctatgagcgaccccccttt
gcccagattgcgctacagctaggccgcatgctggaagccaggaaggcctatgtgaacatg
tcgctgtttgagaacttcacttacgcgggcattgatgccacagctgaggaggcctga

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