| Entry |
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| Symbol |
TRIO, ARHGEF23, MEBAS, MRD44, MRD63, tgat
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| Name |
(RefSeq) trio Rho guanine nucleotide exchange factor
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| KO |
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| Organism |
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| Network |
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| Element |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
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| Disease |
| H00773 | Autosomal dominant intellectual developmental disorder |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
7204 (TRIO)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
7204 (TRIO)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
7204 (TRIO)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CAMK group
Trio family [OT]
7204 (TRIO)
Membrane trafficking [BR:hsa04131]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
7204 (TRIO)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
5:14143342..14510204
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| AA seq |
3097 aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM
KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC
KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI
LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG
NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR
QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL
EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL
HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV
RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI
KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN
LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT
HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS
EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY
VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI
QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF
QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL
IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG
RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG
QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS
SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG
EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK
MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED
PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP
VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA
QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV
SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL
TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR
IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE
GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP
LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG
KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI
LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK
KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE
TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI
AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR
AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC
VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA
VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET
CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV |
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| NT seq |
9294 nt +upstreamnt +downstreamnt
atgagcggcagcagcggcggagccgccgcccccgccgcgtcctccggccccgccgcggcg
gccagcgcggctggctcgggctgcgggggcggtgccggcgagggggcagaggaggcggcc
aaggacctggccgacatcgcggccttcttccgatccgggtttcgaaaaaacgatgaaatg
aaagctatggatgttttaccaattttgaaggaaaaagttgcatacctttcaggtgggaga
gataaacgtggaggtcccattttaacgtttccggcccgcagcaatcatgacagaatacga
caggaggatctcaggagactcatttcctatctagcctgtattcccagcgaggaggtctgc
aagcgtggcttcacggtgatcgtggacatgcgtgggtccaagtgggactccatcaagccc
cttctgaagatcctgcaggagtccttcccctgctgcatccatgtggccctgatcatcaag
ccagacaacttctggcagaaacagaggactaattttggcagttctaaatttgaatttgag
acaaatatggtctctttagaaggccttaccaaagtagttgatccttctcagctaactcct
gagtttgatggctgcctggaatacaaccacgaagaatggattgaaatcagagttgctttt
gaagactacattagcaatgccacccacatgctgtctcggctggaggaacttcaggacatc
ctagctaagaaggagctgcctcaggatttagagggggctcggaatatgatcgaggaacat
tctcagctgaagaagaaggtgattaaggcccccatcgaggacctggatttggagggacag
aagctgcttcagaggatacagagcagtgaaagctttcccaaaaagaactcaggctcaggc
aatgcggacctgcagaacctcttgcccaaggtgtccaccatgctggaccggctgcactcg
acacggcagcatctgcaccagatgtggcatgtgaggaagctgaagctggaccagtgcttc
cagctgaggctgtttgaacaggatgctgagaagatgtttgactggatcacacacaacaaa
ggcctgtttctaaacagctacacagagattgggaccagccaccctcatgccatggagctt
cagacgcagcacaatcactttgccatgaactgtatgaacgtgtatgtaaatataaaccgc
atcatgtcggtggccaatcgtctggtggagtctggccactatgcctcgcagcagatcagg
cagatcgcgagtcagctggagcaggagtggaaggcgtttgcggcagccctggatgagcgg
agcaccttgctggacatgtcctccattttccaccagaaggccgaaaagtatatgagcaac
gtggattcatggtgtaaagcttgcggtgaggtagaccttccctcagagctgcaggaccta
gaagatgccattcatcaccaccagggaatatatgaacatatcactcttgcttattctgag
gtcagccaagatgggaagtcgctccttgacaagctccagcggcccttgactcccggcagc
tccgattccctgacagcctctgccaactactccaaggccgtgcaccatgtcctggatgtc
atccacgaggtgctgcaccaccagcggcagctggagaacatctggcaacaccgcaaggtc
cggctgcatcagaggctgcagctgtgtgttttccagcaggacgttcagcaggtgctagac
tggatcgagaaccacggagaagcatttctgagcaaacatacaggtgtggggaaatctctt
catcgggccagagcattgcagaaacgtcatgaagattttgaagaagtggcacagaacaca
tacaccaatgcggataaattactggaagcagcagaacagctggctcagactggggaatgt
gaccccgaagagatttatcaggctgcccatcagctggaagaccggattcaagatttcgtt
cggcgtgttgagcagcgaaagatcctactggacatgtcagtgtcctttcacacccatgtg
aaagagctgtggacgtggctggaggagctgcagaaggagctgctggacgacgtgtatgcc
gagtcggtggaggccgtgcaggacctcatcaagcgctttggccagcagcagcagaccacc
ctgcaggtgactgtcaacgtgatcaaggaaggggaggacctcatccagcagctcagggac
tctgccatctccagtaacaagaccccccacaacagctccatcaaccacattgagacggtg
ctgcagcagctggacgaggcgcagtcgcagatggaggagctcttccaggagcgcaagatc
aagctggagctcttcctgcagctgcgcatcttcgagagggacgccatcgacattatctca
gacctcgagtcttggaatgatgagctttctcagcaaatgaatgacttcgacacagaagat
ctcacgattgcagagcagcgcctccagcaccatgcagacaaagccttgaccatgaacaac
ttgacttttgacgtcatccaccaagggcaagatcttctgcagtatgtcaatgaggtccag
gcctctggtgtggagctgctgtgtgatagagatgtagacatggcaactcgggtccaggac
ctgctggagtttcttcatgaaaaacagcaggaattggatttagccgcagagcagcatcgg
aaacacctggagcagtgcgtgcagctgcgccacctgcaggcagaagtgaaacaggtgctg
ggttggatccgcaacggagagtccatgttaaatgccggacttatcacagccagctcgtta
caagaggcagagcagctccagcgagagcacgagcagttccagcatgccattgagaaaaca
catcagagcgcgctgcaggtgcagcagaaggcagaagccatgctacaggccaaccactac
gacatggacatgatccgggactgcgccgagaaggtggcgtctcactggcaacagctcatg
ctcaagatggaagatcgcctcaagctcgtcaacgcctctgtcgctttctacaaaacctca
gagcaggtctgcagcgtcctcgagagcctggaacaggagtacaagagagaagaagactgg
tgtggcggggcggataagctgggcccaaactctgagacggaccacgtgacgcccatgatc
agcaagcacctggagcagaaggaggcattcctgaaggcttgcacccttgctcggaggaat
gcagacgtcttcctgaaatacctgcacaggaacagcgtgaacatgccaggaatggtgacg
cacatcaaagctcctgaacagcaagtgaaaaatatcttgaatgaactcttccaacgggag
aacagggtattgcattactggaccatgaggaagagacggctggaccagtgtcagcagtac
gtggtctttgagaggagtgccaagcaggctttggaatggatccatgacaatggcgagttc
tacctttccacacacacctccacgggctccagtatacagcacacccaggagctcctgaaa
gagcacgaggagttccagataactgcaaagcaaaccaaagagagagtgaagctattgata
cagctggctgatggcttttgtgaaaaagggcatgcccatgcggcagagataaaaaaatgt
gttactgctgtggataagaggtacagagatttctctctgcggatggagaagtacaggacc
tctttggaaaaagccctggggatttcttcagattccaacaaatcgagtaaaagtctccag
ctagatatcattccagccagtatccctggctcagaggtgaaacttcgagatgctgctcat
gaacttaatgaagagaagcggaaatctgcccgcaggaaagagttcataatggctgagctc
attcaaactgaaaaggcttatgtaagagacctccgggaatgtatggatacgtacctgtgg
gaaatgaccagtggcgtggaagagattccacctggcattgtaaacaaagaactcatcatc
ttcggaaacatgcaagaaatctacgaatttcataataacatattcctaaaggagctggaa
aaatatgaacagttgccagaggatgttggacattgttttgttacttgggcagacaagttt
cagatgtatgtcacatattgcaaaaataagcctgattctactcagctgatattggaacat
gcagggtcctattttgacgagatacagcagcgacatggattagccaattccatttcttcc
taccttattaaaccagttcagcgaataacgaagtatcagctccttttaaaagagctgctg
acgtgctgtgaggaaggaaagggagagattaaagatggcctggaggtgatgctcagcgtg
ccgaagcgagccaatgatgccatgcacctcagcatgctggaagggtttgatgaaaacatt
gagtctcagggagaactcatcctacaggaatccttccaagtgtgggacccaaaaacctta
attcgaaagggtcgagaacggcatctcttcctttttgaaatgtccttagtatttagtaaa
gaagtgaaagattccagtgggagaagcaagtacctttataaaagcaaattgtttacctca
gagttgggtgtcacagaacatgttgaaggagacccttgcaaatttgcactgtgggtgggg
agaacaccaacttcagataataaaattgtccttaaggcttccagcatagagaacaagcag
gactggataaagcatatccgcgaagtcatccaggagcggacgatccacctgaagggagcc
ctgaaggagcccattcacatccctaagaccgctcccgccacaagacagaagggaaggagg
gatggagaggatctggacagccaaggagacggcagcagccagcctgatacgatttccatc
gcctcacggacgtctcagaacacgctggacagcgataagctctctggtggctgtgagctg
acagtggtgatccatgacttcaccgcttgcaacagcaacgagctgaccatccgacggggc
cagaccgtggaagttctggagcggccgcatgacaagcctgactggtgtctggtgcggaca
actgaccgctccccagcggcagaaggcctggtcccctgtggttcactgtgcatcgcccac
tccagaagtagcatggaaatggagggcatcttcaaccacaaagactcgctctccgtctcc
agcaatgacgccagtccacccgcatccgtggcttccctccagccccacatgatcggggcc
cagagctcgccgggccccaagcggccgggcaacaccctgcgcaagtggctcaccagcccc
gtgcggcggctcagcagcggcaaggccgacgggcacgtgaagaagctggcgcacaagcac
aagaagagccgcgaggtccgcaagagcgccgacgccggctcgcagaaggactccgacgac
agtgcggccaccccgcaggacgagacggtcgaggagagaggccggaacgagggcctgagc
agcggtactctctccaaatcctcctcctcggggatgcagagctgtggagaagaggaaggc
gaggagggggccgacgccgtgcccctgccgccacccatggccatccagcagcacagcctc
ctccagccagactcacaggatgacaaggcctcttctcggttattagtccgccccaccagc
tccgaaacaccgagtgcagccgagctcgtcagtgcaattgaggaactcgtgaaaagcaag
atggcactggaggatcgccccagctcactccttgttgaccagggagatagtagcagccct
tccttcaacccttcggataattcccttctctcttcctcctcgcccattgatgagatggaa
gaaaggaaatccagctctttaaagagaagacactacgttttgcaagaactagtggagaca
gagcgtgactatgtgcgggaccttggctatgtggttgagggctacatggcacttatgaaa
gaagatggtgttcctgatgacatgaaaggaaaagacaaaattgtgttcggcaacatccat
cagatttacgactggcacagagacttttttttaggagagttagagaagtgccttgaagat
ccagaaaaactaggatccctttttgttaaacacgagagaaggttgcacatgtacatagct
tattgtcaaaataaaccaaagtctgagcacattgtctcagaatacattgatacctttttt
gaggacttaaagcagcgtcttggccacaggttacagctcacagatctgttgatcaaacca
gtgcagagaatcatgaagtatcagctgttactgaaggacttcctcaagtattccaaaaag
gccagcctggatacatcagaattagagagagctgtggaagtcatgtgcatagtacccagg
cggtgcaacgacatgatgaacgtggggcggctgcaaggattcgacgggaaaatcgttgcc
cagggtaaactgctcttgcaggacacattcttggtcacagaccaagatgcaggacttctg
cctcgctgcagagagaggcgcatcttcctctttgagcagatcgtcatattcagcgaacca
cttgataaaaagaagggcttctccatgccgggattcctgtttaagaacagtatcaaggtg
agttgcctttgcctggaggaaaatgtggaaaatgatccctgtaaatttgctctgacatcg
aggacgggtgacgtggtagagaccttcattttgcattcatctagtccaagtgtccggcaa
acttggatccatgaaatcaaccaaattttagaaaaccagcgcaattttttaaatgccttg
acatcgccaatcgagtaccagaggaaccacagcgggggcggcggcggcggcggcagcggg
ggcagcggcgggggtgggggcagcggcggcggcggggcccccagtggcggcagcggccac
agtggcggccccagcagctgcggcggcgcccccagcacgagcaggagccggccctcccgg
atcccccagcctgtccgacaccacccccccgtgctggtctcctctgcagcctcgagccag
gcagaggcagacaagatgtcaggtacgtccacccccgggccctccctgcctccccctggc
gcggcccccgaggccggccccagcgcgcccagcaggcggccccccggcgcggacgccgag
gggtccgagcgagaagcggagccgatccccaagatgaaggtgctggagagccccaggaaa
ggcgccgcgaacgcctcggggtcgagcccagacgcccccgccaaggacgcgcgcgctagc
ctgggcaccctgccgcttgggaagccccgggccggggccgcttcgccgctgaactcgccg
ctctccagcgcggtcccttctctcggcaaggagcccttcccccccagcagccccctgcag
aaggggggctccttctggagctccatccccgcctcccccgccagccgacccggctccttc
accttcccgggggacagcgactccctccagcggcagacaccccgccacgcggcccctggc
aaggatactgaccgcatgagcacgtgctcctcggccagcgagcagtccgtgcagtccacc
cagagcaacgggagtgaaagcagcagcagtagcaacatctccaccatgttggtgacacac
gattacacggcagtgaaggaggatgagatcaacgtctaccaaggagaggtcgttcaaatt
ctggccagcaaccagcagaacatgtttctggtgttccgagccgccactgaccagtgcccc
gcagctgagggctggattccaggctttgtcctgggccacaccagtgcagtcatcgtggag
aacccggacgggactctcaagaagtcaacatcttggcacacagcactccgtttaaggaaa
aaatctgagaaaaaagataaagacggcaaaagggaaggcaagttagagaacggttatcgg
aagtcacgggaaggactcagcaacaaggtatctgtgaagcttctcaatcccaactacatt
tatgacgttcccccagaattcgtcattccattgagtgaggtcacgtgtgagacaggggag
accgttgttcttagatgtcgagtctgtggccgccccaaagcctcaattacctggaagggc
cctgaacacaacaccttgaacaacgatggtcactacagcatctcctacagtgacctggga
gaggccacgctgaagattgtgggcgtgaccacggaagatgacggcatctacacgtgcatc
gctgtcaatgacatgggttcagcctcatcgtcggccagcctgagggtcctaggtccaggg
atggatgggatcatggtgacctggaaagacaactttgactccttctacagtgaagtggct
gagcttggcaggggcagattctctgtcgttaagaaatgtgatcagaaaggaaccaagcga
gcagtggccactaagtttgtgaacaagaagttgatgaagcgcgaccaggtcacccatgag
cttggcatcctgcagagcctccagcaccccctgcttgtcggcctcctcgacacctttgag
acccccaccagctacatcctggtcttagaaatggctgaccagggtcgcctcctggactgc
gtggtgcgatggggaagcctcactgaagggaagatcagggcgcacctgggggaggttctg
gaagctgtccggtacctgcacaactgcaggatagcacacctggacctaaagcctgagaat
atcctggtggatgagagtttagccaagccaaccatcaaactggctgactttggagatgct
gttcagctcaacacgacctactacatccaccagttactggggaaccctgaattcgcagcc
cctgaaatcatcctcgggaaccctgtctccctgacctcggatacgtggagtgttggagtg
ctcacatacgtacttcttagtggcgtgtcccccttcctggatgacagtgtggaagagacc
tgcctgaacatttgccgcttagactttagcttcccagatgactactttaaaggagtgagc
cagaaggccaaggagttcgtgtgcttcctcctgcaggaggaccccgccaagcgtccctcg
gctgcgctggccctccaggagcagtggctgcaggccggcaacggcagaagcacgggcgtc
ctcgacacgtccagactgacttccttcattgagcggcgcaaacaccagaatgatgttcga
cctatccgtagcattaaaaactttctgcagagcaggcttctgcctagagtttga |
|---|
