KEGG   Homo sapiens (human): 84451
Entry
84451             CDS       T01001                                 
Symbol
MAP3K21, MLK4, dJ862P8.3
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 21
  KO
K17534  mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    84451 (MAP3K21)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     84451 (MAP3K21)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   84451 (MAP3K21)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 ABC1 Pkinase_fungal RNase_Y_N
Other DBs
NCBI-GeneID: 84451
NCBI-ProteinID: NP_115811
OMIM: 614793
HGNC: 29798
Ensembl: ENSG00000143674
UniProt: Q5TCX8
Structure
LinkDB
Position
1:233327724..233385148
AA seq 1036 aa
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
NT seq 3111 nt   +upstreamnt  +downstreamnt
atggctttgcggggcgccgcgggagcgaccgacaccccggtgtcctcggccgggggagcc
cccggcggctcagcgtcctcgtcgtccacctcctcgggcggctcggcctcggcgggcgcg
gggctgtgggccgcgctctatgactacgaggctcgcggcgaggacgagctgagcctgcgg
cgcggccagctggtggaggtgctgtcgcaggacgccgccgtgtcgggcgacgagggctgg
tgggcaggccaggtgcagcggcgcctcggcatcttccccgccaactacgtggctccctgc
cgcccggccgccagccccgcgccgccgccctcgcggcccagctccccggtacacgtcgcc
ttcgagcggctggagctgaaggagctcatcggcgctgggggcttcgggcaggtgtaccgc
gccacctggcagggccaggaggtggccgtgaaggcggcgcgccaggacccggagcaggac
gcggcggcggctgccgagagcgtgcggcgcgaggctcggctcttcgccatgctgcggcac
cccaacatcatcgagctgcgcggcgtgtgcctgcagcagccgcacctctgcctggtgctg
gagttcgcccgcggcggagcgctcaaccgagcgctggccgctgccaacgccgccccggac
ccgcgcgcgcccggcccccgccgcgcgcgccgcatccctccgcacgtgctggtcaactgg
gccgtgcagatagcgcggggcatgctctacctgcatgaggaggccttcgtgcccatcctg
caccgggacctcaagtccagcaacattttgctacttgagaagatagaacatgatgacatc
tgcaataaaactttgaagattacagattttgggttggcgagggaatggcacaggaccacc
aaaatgagcacagcaggcacctatgcctggatggcccccgaagtgatcaagtcttccttg
ttttctaagggaagcgacatctggagctatggagtgctgctgtgggaactgctcaccgga
gaagtcccctatcggggcattgatggcctcgccgtggcttatggggtagcagtcaataaa
ctcactttgcccattccatccacctgccctgagccgtttgccaagctcatgaaagaatgc
tggcaacaagaccctcatattcgtccatcgtttgccttaattctcgaacagttgactgct
attgaaggggcagtgatgactgagatgcctcaagaatcttttcattccatgcaagatgac
tggaaactagaaattcaacaaatgtttgatgagttgagaacaaaggaaaaggagctgcga
tcccgggaagaggagctgactcgggcggctctgcagcagaagtctcaggaggagctgcta
aagcggcgtgagcagcagctggcagagcgcgagatcgacgtgctggagcgggaacttaac
attctgatattccagctaaaccaggagaagcccaaggtaaagaagaggaagggcaagttt
aagagaagtcgtttaaagctcaaagatggacatcgaatcagtttaccttcagatttccag
cacaagataaccgtgcaggcctctcccaacttggacaaacggcggagcctgaacagcagc
agttccagtcccccgagcagccccacaatgatgccccgactccgagccatacagttgact
tcagatgaaagcaataaaacttggggaaggaacacagtctttcgacaagaagaatttgag
gatgtaaaaaggaattttaagaaaaaaggttgtacctggggaccaaattccattcaaatg
aaagatagaacagattgcaaagaaaggataagacctctctccgatggcaacagtccttgg
tcaactatcttaataaaaaatcagaaaaccatgcccttggcttcattgtttgtggaccag
ccagggtcctgtgaagagccaaaactttcccctgatggattagaacacagaaaaccaaaa
caaataaaattgcctagtcaggcctacattgatctacctcttgggaaagatgctcagaga
gagaatcctgcagaagctgaaagctgggaggaggcagcctctgcgaatgctgccacagtc
tccattgagatgactcctacgaatagtctgagtagatccccccagagaaagaaaacggag
tcagctctgtatgggtgcaccgtccttctggcatcggtggctctgggactggacctcaga
gagcttcataaagcacaggctgctgaagaaccgttgcccaaggaagagaagaagaaacga
gagggaatcttccagcgggcttccaagtcccgcagaagcgccagtcctcccacaagcctg
ccatccacctgtggggaggccagcagcccaccctccctgccactgtcaagtgccctgggc
atcctctccacaccttctttctccacaaagtgcctgctgcagatggacagtgaagatcca
ctggtggacagtgcacctgtcacttgtgactctgagatgctcactccggatttttgtccc
actgccccaggaagtggtcgtgagccagccctcatgccaagacttgacactgattgtagt
gtatcaagaaacttgccgtcttccttcctacagcagacatgtgggaatgtaccttactgt
gcttcttcaaaacatagaccgtcacatcacagacggaccatgtctgatggaaatccgacc
ccaactggtgcaactattatctcagccactggagcctctgcactgccactctgcccctca
cctgctcctcacagtcatctgccaagggaggtctcacccaagaagcacagcactgtccac
atcgtgcctcagcgtcgccctgcctccctgagaagccgctcagatctgcctcaggcttac
ccacagacagcagtgtctcagctggcacagactgcctgtgtagtgggtcgcccaggacca
catcccacccaattcctcgctgccaaggagagaactaaatcccatgtgccttcattactg
gatgctgacgtggaaggtcagagcagggactacactgtgccactgtgcagaatgaggagc
aaaaccagccggccatctatatatgaactggagaaagaattcctgtcttaa

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