| Entry |
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| Symbol |
RIPK1, AIEFL, IMD57, RIP, RIP-1, RIP1
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| Name |
(RefSeq) receptor interacting serine/threonine kinase 1
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| KO |
| K02861 | receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1] |
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| Organism |
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| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05163 | Human cytomegalovirus infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
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| Element |
| N00145 | Extrinsic apoptotic pathway |
| N00151 | TNF-NFKB signaling pathway |
| N00441 | HIV gp120 to TNF-NFKB signaling pathway |
| N00442 | HIV Nef to TNF-NFKB signaling pathway |
| N00444 | TNF-p38 signaling pathway |
| N00446 | TNF-JNK signaling pathway |
| N00928 | Escherichia NleB to TNF-NFKB signaling pathway |
| N00945 | Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway |
| N01113 | Salmonella SseK1 to TNF-NFKB signaling pathway |
| N01545 | Regulation of TNF-NFKB signaling pathway, LUBAC-mediated linear ubiquitination |
| N01546 | Regulation of TNF-NFKB signaling pathway, OTULIN/TNFAIP3-mediated deubiquitination |
| N01583 | Regulation of extrinsic apoptotic pathway, XIAP |
| N01621 | TNF-RIPK1/3 signaling pathway |
| N01625 | CYLD regulation of RIPK1/3 |
| N01631 | TNFSF10-RIPK1/3 signaling pathway |
| N01632 | FASLG-RIPK1/3 signaling pathway |
| N01650 | SQSTM1 regulation of RIPK1/3 |
| N01662 | IFN-RIPK1/3 signaling pathway |
| N01663 | CASP8 regulation of RIPK1/3 |
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| Disease |
| H02525 | Disorders of innate immunity |
| H02620 | Autoinflammation with episodic fever and lymphadenopathy |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
8737 (RIPK1)
04668 TNF signaling pathway
8737 (RIPK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
8737 (RIPK1)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
8737 (RIPK1)
05160 Hepatitis C
8737 (RIPK1)
05163 Human cytomegalovirus infection
8737 (RIPK1)
05169 Epstein-Barr virus infection
8737 (RIPK1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
8737 (RIPK1)
05131 Shigellosis
8737 (RIPK1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
8737 (RIPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
8737 (RIPK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
8737 (RIPK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
RIPK family [OT]
8737 (RIPK1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
6:3063967..3115187
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| AA seq |
671 aa
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN |
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| NT seq |
2016 nt +upstreamnt +downstreamnt
atgcaaccagacatgtccttgaatgtcattaagatgaaatccagtgacttcctggagagt
gcagaactggacagcggaggctttgggaaggtgtctctgtgtttccacagaacccaggga
ctcatgatcatgaaaacagtgtacaaggggcccaactgcattgagcacaacgaggccctc
ttggaggaggcgaagatgatgaacagactgagacacagccgggtggtgaagctcctgggc
gtcatcatagaggaagggaagtactccctggtgatggagtacatggagaagggcaacctg
atgcacgtgctgaaagccgagatgagtactccgctttctgtaaaaggaaggataattttg
gaaatcattgaaggaatgtgctacttacatggaaaaggcgtgatacacaaggacctgaag
cctgaaaatatccttgttgataatgacttccacattaagatcgcagacctcggccttgcc
tcctttaagatgtggagcaaactgaataatgaagagcacaatgagctgagggaagtggac
ggcaccgctaagaagaatggcggcaccctctactacatggcgcccgagcacctgaatgac
gtcaacgcaaagcccacagagaagtcggatgtgtacagctttgctgtagtactctgggcg
atatttgcaaataaggagccatatgaaaatgctatctgtgagcagcagttgataatgtgc
ataaaatctgggaacaggccagatgtggatgacatcactgagtactgcccaagagaaatt
atcagtctcatgaagctctgctgggaagcgaatccggaagctcggccgacatttcctggc
attgaagaaaaatttaggcctttttatttaagtcaattagaagaaagtgtagaagaggac
gtgaagagtttaaagaaagagtattcaaacgaaaatgcagttgtgaagagaatgcagtct
cttcaacttgattgtgtggcagtaccttcaagccggtcaaattcagccacagaacagcct
ggttcactgcacagttcccagggacttgggatgggtcctgtggaggagtcctggtttgct
ccttccctggagcacccacaagaagagaatgagcccagcctgcagagtaaactccaagac
gaagccaactaccatctttatggcagccgcatggacaggcagacgaaacagcagcccaga
cagaatgtggcttacaacagagaggaggaaaggagacgcagggtctcccatgaccctttt
gcacagcaaagaccttacgagaattttcagaatacagagggaaaaggcactgcttattcc
agtgcagccagtcatggtaatgcagtgcaccagccctcagggctcaccagccaacctcaa
gtactgtatcagaacaatggattatatagctcacatggctttggaacaagaccactggat
ccaggaacagcaggtcccagagtttggtacaggccaattccaagtcatatgcctagtctg
cataatatcccagtgcctgagaccaactatctaggaaatacacccaccatgccattcagc
tccttgccaccaacagatgaatctataaaatataccatatacaatagtactggcattcag
attggagcctacaattatatggagattggtgggacgagttcatcactactagacagcaca
aatacgaacttcaaagaagagccagctgctaagtaccaagctatctttgataataccact
agtctgacggataaacacctggacccaatcagggaaaatctgggaaagcactggaaaaac
tgtgcccgtaaactgggcttcacacagtctcagattgatgaaattgaccatgactatgag
cgagatggactgaaagaaaaggtttaccagatgctccaaaagtgggtgatgagggaaggc
ataaagggagccacggtggggaagctggcccaggcgctccaccagtgttccaggatcgac
cttctgagcagcttgatttacgtcagccagaactaa |
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