KEGG T01001: 9020

Homo sapiens (human): 9020

Entry

9020              CDS       T01001

Symbol

MAP3K14, FTDCR1B, HS, HSNIK, IMD112, NIK

Name

(RefSeq) mitogen-activated protein kinase kinase kinase 14

K04466

mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04210

Apoptosis

hsa04380

Osteoclast differentiation

hsa04625

C-type lectin receptor signaling pathway

hsa04660

T cell receptor signaling pathway

hsa04668

TNF signaling pathway

hsa04672

Intestinal immune network for IgA production

hsa04936

Alcoholic liver disease

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05208

Chemical carcinogenesis - reactive oxygen species

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF signaling (cancer)
nt06516  TNF signaling

Element

N00505

CD40-NFKB signaling pathway

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    9020 (MAP3K14)
   04668 TNF signaling pathway
    9020 (MAP3K14)
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    9020 (MAP3K14)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    9020 (MAP3K14)
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    9020 (MAP3K14)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9020 (MAP3K14)
   05169 Epstein-Barr virus infection
    9020 (MAP3K14)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    9020 (MAP3K14)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    9020 (MAP3K14)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9020 (MAP3K14)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     9020 (MAP3K14)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: STE group
  Other
   9020 (MAP3K14)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr APH Pkinase_fungal TCAD9

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(45263119..45317020)

AA seq 947 aa
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP

NT seq 2844 nt +upstreamnt +downstreamnt
atggcagtgatggaaatggcctgcccaggtgcccctggctcagcagtggggcagcagaag
gaactccccaaagccaaggagaagacgccgccactggggaagaaacagagctccgtctac
aagcttgaggccgtggagaagagccctgtgttctgcggaaagtgggagatcctgaatgac
gtgattaccaagggcacagccaaggaaggctccgaggcagggccagctgccatctctatc
atcgcccaggctgagtgtgagaatagccaagagttcagccccaccttttcagaacgcatt
ttcatcgctgggtccaaacagtacagccagtccgagagtcttgatcagatccccaacaat
gtggcccatgctacagagggcaaaatggcccgtgtgtgttggaagggaaagcgtcgcagc
aaagcccggaagaaacggaagaagaagagctcaaagtccctggctcatgcaggagtggcc
ttggccaaacccctccccaggacccctgagcaggagagctgcaccatcccagtgcaggag
gatgagtctccactcggcgccccatatgttagaaacaccccgcagttcaccaagcctctg
aaggaaccaggccttgggcaactctgttttaagcagcttggcgagggcctacggccggct
ctgcctcgatcagaactccacaaactgatcagccccttgcaatgtctgaaccacgtgtgg
aaactgcaccacccccaggacggaggccccctgcccctgcccacgcaccccttcccctat
agcagactgcctcatcccttcccattccaccctctccagccctggaaacctcaccctctg
gagtccttcctgggcaaactggcctgtgtagacagccagaaacccttgcctgacccacac
ctgagcaaactggcctgtgtagacagtccaaagcccctgcctggcccacacctggagccc
agctgcctgtctcgtggtgcccatgagaagttttctgtggaggaatacctagtgcatgct
ctgcaaggcagcgtgagctcaggccaggcccacagcctgaccagcctggccaagacctgg
gcagcaaggggctccagatcccgggagcccagccccaaaactgaggacaacgagggtgtc
ctgctcactgagaaactcaagccagtggattatgagtaccgagaagaagtccactgggcc
acgcaccagctccgcctgggcagaggctccttcggagaggtgcacaggatggaggacaag
cagactggcttccagtgcgctgtcaaaaaggtgcggctggaagtatttcgggcagaggag
ctgatggcatgtgcaggattgacctcacccagaattgtccctttgtatggagctgtgaga
gaagggccttgggtcaacatcttcatggagctgctggaaggtggctccctgggccagctg
gtcaaggagcagggctgtctcccagaggaccgggccctgtactacctgggccaggccctg
gagggtctggaatacctccactcacgaaggattctgcatggggacgtcaaagctgacaac
gtgctcctgtccagcgatgggagccacgcagccctctgtgactttggccatgctgtgtgt
cttcaacctgatggcctgggaaagtccttgctcacaggggactacatccctggcacagag
acccacatggctccggaggtggtgctgggcaggagctgcgacgccaaggtggatgtctgg
agcagctgctgtatgatgctgcacatgctcaacggctgccacccctggactcagttcttc
cgagggccgctctgcctcaagattgccagcgagcctccgcctgtgagggagatcccaccc
tcctgcgcccctctcacagcccaggccatccaagaggggctgaggaaagagcccatccac
cgcgtgtctgcagcggagctgggagggaaggtgaaccgggcactacagcaagtgggaggt
ctgaagagcccttggaggggagaatataaagaaccaagacatccaccgccaaatcaagcc
aattaccaccagaccctccatgcccagccgagagagctttcgccaagggccccagggccc
cggccagctgaggagacaacaggcagagcccctaagctccagcctcctctcccaccagag
cccccagagccaaacaagtctcctcccttgactttgagcaaggaggagtctgggatgtgg
gaacccttacctctgtcctccctggagccagcccctgccagaaaccccagctcaccagag
cggaaagcaaccgtcccggagcaggaactgcagcagctggaaatagaattattcctcaac
agcctgtcccagccattttctctggaggagcaggagcaaattctctcgtgcctcagcatc
gacagcctctccctgtcggatgacagtgagaagaacccatcaaaggcctctcaaagctcg
cgggacaccctgagctcaggcgtacactcctggagcagccaggccgaggctcgaagctcc
agctggaacatggtgctggcccgggggcggcccaccgacaccccaagctatttcaatggt
gtgaaagtccaaatacagtctcttaatggtgaacacctgcacatccgggagttccaccgg
gtcaaagtgggagacatcgccactggcatcagcagccagatcccagctgcagccttcagc
ttggtcaccaaagacgggcagcctgttcgctacgacatggaggtgccagactcgggcatc
gacctgcagtgcacactggcccctgatggcagcttcgcctggagctggagggtcaagcat
ggccagctggagaacaggccctaa

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