KEGG   Mus musculus (house mouse): 56637
Entry
56637             CDS       T01002                                 
Symbol
Gsk3b, 7330414F15Rik, 8430431H08Rik, GSK-3, GSK-3beta, GSK3
Name
(RefSeq) glycogen synthase kinase 3 beta
  KO
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04012  ErbB signaling pathway
mmu04062  Chemokine signaling pathway
mmu04110  Cell cycle
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04310  Wnt signaling pathway
mmu04340  Hedgehog signaling pathway
mmu04360  Axon guidance
mmu04390  Hippo signaling pathway
mmu04510  Focal adhesion
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04657  IL-17 signaling pathway
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04722  Neurotrophin signaling pathway
mmu04728  Dopaminergic synapse
mmu04910  Insulin signaling pathway
mmu04916  Melanogenesis
mmu04917  Prolactin signaling pathway
mmu04919  Thyroid hormone signaling pathway
mmu04931  Insulin resistance
mmu04932  Non-alcoholic fatty liver disease
mmu04934  Cushing syndrome
mmu04935  Growth hormone synthesis, secretion and action
mmu04936  Alcoholic liver disease
mmu05010  Alzheimer disease
mmu05020  Prion disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05135  Yersinia infection
mmu05160  Hepatitis C
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05200  Pathways in cancer
mmu05210  Colorectal cancer
mmu05213  Endometrial cancer
mmu05215  Prostate cancer
mmu05217  Basal cell carcinoma
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
mmu05415  Diabetic cardiomyopathy
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    56637 (Gsk3b)
   04390 Hippo signaling pathway
    56637 (Gsk3b)
   04151 PI3K-Akt signaling pathway
    56637 (Gsk3b)
   04150 mTOR signaling pathway
    56637 (Gsk3b)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    56637 (Gsk3b)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    56637 (Gsk3b)
   04657 IL-17 signaling pathway
    56637 (Gsk3b)
   04662 B cell receptor signaling pathway
    56637 (Gsk3b)
   04062 Chemokine signaling pathway
    56637 (Gsk3b)
  09152 Endocrine system
   04917 Prolactin signaling pathway
    56637 (Gsk3b)
   04935 Growth hormone synthesis, secretion and action
    56637 (Gsk3b)
   04919 Thyroid hormone signaling pathway
    56637 (Gsk3b)
  09156 Nervous system
   04728 Dopaminergic synapse
    56637 (Gsk3b)
   04722 Neurotrophin signaling pathway
    56637 (Gsk3b)
  09158 Development and regeneration
   04360 Axon guidance
    56637 (Gsk3b)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    56637 (Gsk3b)
  09162 Cancer: specific types
   05210 Colorectal cancer
    56637 (Gsk3b)
   05225 Hepatocellular carcinoma
    56637 (Gsk3b)
   05226 Gastric cancer
    56637 (Gsk3b)
   05217 Basal cell carcinoma
    56637 (Gsk3b)
   05215 Prostate cancer
    56637 (Gsk3b)
   05213 Endometrial cancer
    56637 (Gsk3b)
   05224 Breast cancer
    56637 (Gsk3b)
  09172 Infectious disease: viral
   05160 Hepatitis C
    56637 (Gsk3b)
   05162 Measles
    56637 (Gsk3b)
   05163 Human cytomegalovirus infection
    56637 (Gsk3b)
   05167 Kaposi sarcoma-associated herpesvirus infection
    56637 (Gsk3b)
   05165 Human papillomavirus infection
    56637 (Gsk3b)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    56637 (Gsk3b)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    56637 (Gsk3b)
   05020 Prion disease
    56637 (Gsk3b)
   05022 Pathways of neurodegeneration - multiple diseases
    56637 (Gsk3b)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    56637 (Gsk3b)
   05415 Diabetic cardiomyopathy
    56637 (Gsk3b)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    56637 (Gsk3b)
   04932 Non-alcoholic fatty liver disease
    56637 (Gsk3b)
   04931 Insulin resistance
    56637 (Gsk3b)
   04934 Cushing syndrome
    56637 (Gsk3b)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    56637 (Gsk3b)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    56637 (Gsk3b)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    56637 (Gsk3b)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.26  tau-protein kinase
     56637 (Gsk3b)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: CMGC group
  GSK family [OT]
   56637 (Gsk3b)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    56637 (Gsk3b)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kinase-like Kdo APH
Other DBs
NCBI-GeneID: 56637
NCBI-ProteinID: NP_062801
MGI: 1861437
Ensembl: ENSMUSG00000022812
UniProt: Q9WV60 Q5KU03
Structure
LinkDB
Position
16:37909363..38066446
AA seq 420 aa
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
NT seq 1263 nt   +upstreamnt  +downstreamnt
atgtcggggcgaccgagaaccacctcctttgcggagagctgcaagccagtgcagcagcct
tcagcttttggtagcatgaaagttagcagagataaagatggcagcaaggtaaccacagta
gtggcaactcctggccagggtcctgacaggccacaggaagtcagttatacagacacgaaa
gtgattggaaatggatcatttggtgtggtatatcaagccaaactttgtgattctggagaa
ctggttgccatcaagaaagttctacaggacaagcgatttaagaaccgagagctccagatc
atgagaaagctagaccactgtaacatagtccgactgcggtatttcttctactcgagtggt
gagaagaaagatgaggtctaccttaacctggtgctggactatgttccggagacagtgtac
agagtcgccagacactatagtcgagccaagcagacactccctgtgatctatgtcaagttg
tatatgtatcagctgttcagaagtctagcctatatccattcctttggaatctgccatcga
gacattaaaccacagaacctcttgttggatcctgatacagctgtattaaaactctgtgac
tttggaagtgcaaagcagctggtccgaggagagcccaatgtttcatatatctgttctcgg
tactacagggcaccagagttgatctttggagccactgattacacgtccagtatagatgta
tggtctgcaggctgtgtgttggctgaattgttgctaggacaaccaatatttcctggggac
agtggtgtggatcagttggtggaaataataaaggtcctaggaacaccaacaagggagcaa
attagagaaatgaacccaaattatacagaattcaaattccctcaaatcaaggcacatcct
tggacaaaggtcttccggccccgaactccaccagaggcaattgcactgtgcagccgtctg
ctggagtacacacctaccgcccggctaacaccactggaagcttgtgcacattcatttttc
gatgaattgcgggacccaaatgtcaaactaccaaatgggcgagacacacctgcactcttc
aactttaccactcaagaactgtcaagtaacccccctctggccaccatccttatccctcca
catgctcggattcaggccgctgcttcaccgcctgccaacgccacagcagcctcagatact
aatgctggagaccgtggacagaccaataacgccgcttctgcatcagcttccaactccacc
tga

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