KEGG   PATHWAY: ago04138
Entry
ago04138                    Pathway                                
Name
Autophagy - yeast - Eremothecium gossypii
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
ago04138  Autophagy - yeast
ago04138

Other DBs
GO: 0006914
Organism
Eremothecium gossypii [GN:ago]
Gene
AGOS_ADL262W  ADL262Wp [KO:K07827]
AGOS_AFL090W  AFL090Wp [KO:K04345] [EC:2.7.11.11]
AGOS_AEL115C  AEL115Cp [KO:K04345] [EC:2.7.11.11]
AGOS_ABR088C  ABR088Cp [KO:K16314] [EC:2.7.11.1]
AGOS_ACL053C  ACL053Cp [KO:K21157] [EC:2.7.11.1]
AGOS_AEL230W  AEL230Wp [KO:K12761] [EC:2.7.11.1]
AGOS_ACL054W  ACL054Wp [KO:K08269] [EC:2.7.11.1]
AGOS_AEL277C  AEL277Cp [KO:K08331]
AGOS_AER106C  AER106Cp [KO:K08329]
AGOS_AER409C  AER409Cp [KO:K21144]
AGOS_AAL098W  AAL098Wp [KO:K21143]
AGOS_ADR071W  ADR071Wp [KO:K17907]
AGOS_ABL208W  ABL208Wp [KO:K17906]
AGOS_AAL119W  AAL119Wp [KO:K17908]
AGOS_ABR189W  ABR189Wp [KO:K17908]
AGOS_AER116C  AER116Cp [KO:K17909]
AGOS_AEL138C  AEL138Cp [KO:K21141]
AGOS_ADL307W  ADL307Wp [KO:K08330]
AGOS_ADR316W  ADR316Wp [KO:K17260]
AGOS_AFR419C  AFR419Cp [KO:K18584]
AGOS_AFL022W  AFL022Wp [KO:K05757]
AGOS_AGL221W  AGL221Wp [KO:K05758]
AGOS_AFR584C  AFR584Cp [KO:K05756]
AGOS_ACL092C  ACL092Cp [KO:K05755]
AGOS_ADL061W  ADL061Wp [KO:K05754]
AGOS_ADL389W  ADL389Wp [KO:K19800] [EC:2.7.11.1]
AGOS_AER232C  AER232Cp [KO:K04464] [EC:2.7.11.24]
AGOS_ABR145C  ABR145Cp [KO:K00654] [EC:2.3.1.50]
AGOS_AGR127C  AGR127Cp [KO:K00654] [EC:2.3.1.50]
AGOS_ADR331C  ADR331Cp [KO:K07204]
AGOS_AFR420W  AFR420Wp [KO:K07203] [EC:2.7.11.1]
AGOS_AAL009C  AAL009Cp [KO:K08266]
AGOS_ABR072W  ABR072Wp [KO:K17606]
AGOS_ADR099C  ADR099Cp [KO:K04382] [EC:3.1.3.16]
AGOS_ACR174C  ACR174Cp [KO:K17607]
AGOS_ACR218W  ACR218Wp [KO:K12767] [EC:2.7.11.36]
AGOS_ABR089C  ABR089Cp [KO:K09468]
AGOS_AAL083W  AAL083Wp [KO:K16196] [EC:2.7.11.1]
AGOS_AGR320W  AGR320Wp [KO:K03237]
AGOS_ADL012C  ADL012Cp [KO:K09464]
AGOS_AGL242C  AGL242Cp [KO:K06655] [EC:2.7.11.22]
AGOS_AAL032W  AAL032Wp [KO:K21197]
AGOS_AGL099C  AGL099Cp [KO:K09243]
AGOS_AER396W  AER396Wp [KO:K08341]
AGOS_ACR154W  ACR154Wp [KO:K08334]
AGOS_ADL381W  ADL381Wp [KO:K08335]
AGOS_ADR074C  ADR074Cp [KO:K21145]
AGOS_ADL316C  ADL316Cp [KO:K08333] [EC:2.7.11.1]
AGOS_AGL113C  AGL113Cp [KO:K00914] [EC:2.7.1.137]
AGOS_AGL144C  AGL144Cp [KO:K00915] [EC:2.7.1.140 2.7.1.151]
AGOS_AAR184W  AAR184Wp [KO:K07756] [EC:2.7.4.21]
AGOS_ABR152C  ABR152Cp [KO:K18083] [EC:3.1.3.64 3.1.3.95]
AGOS_AAR160W  AAR160Wp [KO:K08336]
AGOS_AER298C  AER298Cp [KO:K08337]
AGOS_ACL066C  ACL066Cp [KO:K08338]
AGOS_ACR131C  ACR131Cp [KO:K08339]
AGOS_AFL186W  AFL186Wp [KO:K08340]
AGOS_AFL178W  AFL178Wp [KO:K08343]
AGOS_ABL191W  ABL191Wp [KO:K08342] [EC:3.4.22.-]
AGOS_AFL232W  AFL232Wp [KO:K21155]
AGOS_AER438C  AER438Cp [KO:K08502]
AGOS_AFL168W  AFL168Wp [KO:K08493]
AGOS_AER109W  AER109Wp [KO:K08516]
AGOS_AER169C  AER169Cp [KO:K06027] [EC:3.6.4.6]
AGOS_ABR155C  ABR155Cp [KO:K15296]
AGOS_ACR003C  ACR003Cp [KO:K07897]
AGOS_AAR175C  AAR175Cp [KO:K20195]
AGOS_AAR040C  AAR040Cp [KO:K21156]
AGOS_ABL012C  ABL012Cp [KO:K20179]
AGOS_AGL252W  AGL252Wp [KO:K20180]
AGOS_AGL156W  AGL156Wp [KO:K20181]
AGOS_AER064C  AER064Cp [KO:K20182]
AGOS_AFR341C  AFR341Cp [KO:K20177]
AGOS_AFR002C  AFR002Cp [KO:K20178]
AGOS_AER080W  AER080Wp [KO:K20183]
AGOS_AGR149W  AGR149Wp [KO:K20184]
AGOS_AFL053W  AFL053Wp [KO:K12479]
AGOS_ACR144W  ACR144Wp [KO:K01381] [EC:3.4.23.25]
AGOS_ACR143W  ACR143Wp [KO:K01381] [EC:3.4.23.25]
AGOS_AGR407C  AGR407Cp [KO:K01381] [EC:3.4.23.25]
AGOS_ACR012C  ACR012Cp [KO:K01336] [EC:3.4.21.48 3.4.21.-]
AGOS_AAR046C  AAR046Cp [KO:K17900] [EC:3.1.1.3]
AGOS_AFR714W  AFR714Wp [KO:K06902]
AGOS_AER380C  AER380Cp [KO:K14209]
AGOS_ACR051C  ACR051Cp [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
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