KEGG PATHWAY: bmor04013

KEGG

PATHWAY: bmor04013

Entry

bmor04013                   Pathway

Name

MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

Description

The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.

Class

Environmental Information Processing; Signal transduction

Pathway map

MAPK signaling pathway - fly

Other DBs

GO:

Organism

Bombyx mori (domestic silkworm) [GN:bmor]

Gene

torso-like protein isoform X3 [KO:K12377]

torso-like protein [KO:K12377]

torso; tyrosine-protein kinase receptor torso [KO:K12378] [EC:2.7.10.1]

tyrosine-protein kinase receptor torso [KO:K12378] [EC:2.7.10.1]

protein giant-lens isoform X2 [KO:K02104]

protein vein [KO:K16690]

pro-epidermal growth factor [KO:K16691]

epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]

proto-oncogene tyrosine-protein kinase ROS isoform X1 [KO:K05088] [EC:2.7.10.1]

SHC-transforming protein 1 [KO:K06279]

DRK; DRK protein [KO:K04364]

uncharacterized protein LOC101746155 isoform X2 [KO:K20231]

tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]

tyrosine-protein phosphatase corkscrew [KO:K07293] [EC:3.1.3.48]

protein son of sevenless isoform X1 [KO:K03099]

protein sprouty [KO:K17383]

Ras1; ras-like protein 1 [KO:K07827]

ras GTPase-activating protein 1 [KO:K04352]

GTPase-activating protein isoform X2 [KO:K12380]

raf; raf kinase, effector of Ras [KO:K04365] [EC:2.7.11.1]

14-3-3zeta; 14-3-3 protein zeta [KO:K16197]

serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]

kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]

Mek; MAP kinse-ERK kinase [KO:K04368] [EC:2.7.12.2]

Erk; extracellular regulated MAP kinase [KO:K04371] [EC:2.7.11.24]

uncharacterized protein LOC101736712 [KO:K20220] [EC:3.1.3.48]

importin-7 isoform X2 [KO:K20223]

putative transcription factor capicua [KO:K20225]

nuclear receptor subfamily 2 group E member 1 isoform X1 [KO:K08545]

protein groucho isoform X8 [KO:K04497]

Gro; groucho [KO:K04497]

zinc finger protein 184 [KO:K12379]

ETS-like protein pointed isoform X1 [KO:K02678]

BmEts2; ets DNA-binding protein pokkuri-like [KO:K03211]

ets DNA-binding protein pokkuri [KO:K20232]

exportin-1 [KO:K14290]

protein tramtrack, beta isoform isoform X2 [KO:K09237]

E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]

cysteine and histidine-rich protein 1 isoform X1 [KO:K04506] [EC:2.3.2.27]

F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]

ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]

runt-related transcription factor 3 isoform X1 [KO:K20214]

homeobox protein prospero isoform X1 [KO:K20211]

tumor necrosis factor receptor superfamily member wengen [KO:K16679]

uncharacterized protein LOC101746363 [KO:K20234]

SRC; tyrosine-protein kinase Src42A-like [KO:K08892] [EC:2.7.10.2]

tyrosine-protein kinase Src64B isoform X2 [KO:K05704] [EC:2.7.10.2]

tyrosine-protein kinase Shark [KO:K17512] [EC:2.7.10.2]

serine/threonine-protein kinase mig-15 isoform X3 [KO:K08840] [EC:2.7.11.1]

ras-like GTP-binding protein RhoL [KO:K04392]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-related protein Rac1 [KO:K04392]

TRAF6 [KO:K03175] [EC:2.3.2.27]

ubiquitin carboxyl-terminal hydrolase CYLD isoform X4 [KO:K08601] [EC:3.4.19.12]

uncharacterized protein LOC101743924 isoform X3 [KO:K04404]

mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04417] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]

protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]

mkk7 [KO:K04431] [EC:2.7.12.2]

dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]

Jnk; c-Jun NH2-terminal kinase [KO:K04440] [EC:2.7.11.24]

striatin-3 isoform X1 [KO:K17608]

transcription factor jun-D [KO:K04448]

transcription factor kayak, isoforms D/sro isoform X1 [KO:K09031]

ras-responsive element-binding protein 1 [KO:K20210]

uncharacterized protein LOC101738615 isoform X2 [KO:K20235]

Dpp; decapentaplegic precursor [KO:K04662]

PFN; profilin [KO:K05759]

bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]

mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]

ask1; protein kinase ASK1 [KO:K04426] [EC:2.7.11.25]

LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]

dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04432] [EC:2.7.12.2]

P38mapk; p38 map kinase [KO:K04441] [EC:2.7.11.24]

atf2 [KO:K04450]

dual oxidase-like precursor [KO:K13411] [EC:1.6.3.1 1.11.1.-]

optomotor-blind protein isoform X1 [KO:K10176]

Mef2; myocyte enhancing factor 2 isoform A [KO:K09260]

Sod2; Mn superoxide dismutase [KO:K04564] [EC:1.15.1.1]

Reference

Authors

Sopko R, Perrimon N

Title

Receptor tyrosine kinases in Drosophila development.

Journal

Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050

Reference

Authors

Li WX

Title

Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.

Journal

Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295

Reference

Authors

Shilo BZ

Title

Signaling by the Drosophila epidermal growth factor receptor pathway during development.

Journal

Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0

Reference

Authors

Raabe T

Title

The sevenless signaling pathway: variations of a common theme.

Journal

Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3

Reference

Authors

Rios-Barrera LD, Riesgo-Escovar JR

Title

Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.

Journal

Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354

Reference

Authors

Igaki T, Miura M

Title

The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.

Journal

Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003

Reference

Authors

Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX

Title

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.

Journal

Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013

Reference

Authors

Stronach BE, Perrimon N

Title

Stress signaling in Drosophila.

Journal

Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125

Related
pathway

Apoptosis - fly

KO pathway

LinkDB

DBGET integrated database retrieval system