KEGG   PATHWAY: bta04020
Entry
bta04020                    Pathway                                
Name
Calcium signaling pathway - Bos taurus (cow)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
bta04020  Calcium signaling pathway
bta04020

Other DBs
GO: 0019722
Organism
Bos taurus (cow) [GN:bta]
Gene
100124520  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100125240  PLN; cardiac phospholamban [KO:K05852]
100139857  RYR1; ryanodine receptor 1 [KO:K04961]
100295209  GRIN3A; glutamate receptor ionotropic, NMDA 3A precursor [KO:K05213]
100296455  SLN; sarcolipin [KO:K22642]
100297344  CALM2; calmodulin-2 [KO:K02183]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100300510  [KO:K10785]
100300716  [KO:K06856]
100300806  [KO:K06856]
100300850  [KO:K10784]
100302389  SMIM6; small integral membrane protein 6 [KO:K26468]
100336579  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100336808  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
100336861  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100337083  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100337204  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100847115  [KO:K04282]
101902281  MRLN; myoregulin [KO:K22643]
104968484  [KO:K06856]
104973792  [KO:K02183]
132344463  [KO:K05863]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
281125  DRD1; D(1A) dopamine receptor [KO:K04144]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
281231  HRH1; histamine H1 receptor [KO:K04149]
281350  NGF; beta-nerve growth factor precursor [KO:K02582]
281371  OXTR; oxytocin receptor [KO:K04229]
281549  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
281604  ADRB1; beta-1 adrenergic receptor [KO:K04141]
281605  ADRB2; beta-2 adrenergic receptor [KO:K04142]
281606  ADRB3; beta-3 adrenergic receptor [KO:K04143]
281607  AGTR1; type-1 angiotensin II receptor [KO:K04166]
281665  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
281684  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
281685  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
281686  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
281749  EDNRA; endothelin-1 receptor precursor [KO:K04197]
281750  EDNRB; endothelin receptor type B precursor [KO:K04198]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
281788  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
281789  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281878  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
281900  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
281969  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
281970  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
281986  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282020  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
282088  TACR2; substance-K receptor [KO:K04223]
282119  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
282120  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
282134  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
282146  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
282178  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282330  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
282410  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
282411  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
282412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
282413  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
282478  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
282479  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
282480  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
282641  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
282648  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
282716  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
282861  AVPR1B; vasopressin V1b receptor [KO:K04227]
282876  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
286771  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
286814  P2RX7; P2X purinoceptor 7 [KO:K05220]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
287024  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
317708  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
326597  CALM; calmodulin [KO:K02183]
327677  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
337925  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
338035  P2RX5; P2X purinoceptor 5 [KO:K05219]
338036  P2RX4; P2X purinoceptor 4 [KO:K05218]
338037  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
353111  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
353113  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
386587  GDNF; glial cell line-derived neurotrophic factor precursor [KO:K05452]
404136  TACR3; neuromedin-K receptor [KO:K04224]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
407133  TACR1; substance-P receptor [KO:K04222]
407134  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
407135  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
407140  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
407170  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
407230  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
408015  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
414346  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
497026  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
503620  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
504353  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
505738  MCOLN1; mucolipin-1 isoform 2 [KO:K04992]
505824  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
506207  CCKAR; cholecystokinin receptor type A [KO:K04194]
507437  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
508394  CASQ1; calsequestrin-1 precursor [KO:K23468]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
509486  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
509513  [KO:K10785]
509779  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
510032  TFEB; transcription factor EB [KO:K15590]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
510830  TPCN1; two pore channel protein 1 isoform X4 [KO:K16896]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
511233  ORAI2; protein orai-2 [KO:K16057]
511504  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
511783  PHKB; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
512167  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
512313  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
512670  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
513057  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
513386  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
514345  MCOLN3; mucolipin-3 [KO:K04994]
514667  MST1; hepatocyte growth factor-like protein precursor [KO:K23441]
514898  P2RX1; P2X purinoceptor 1 [KO:K05215]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
515732  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
515924  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
515971  ORAI3; protein orai-3 [KO:K16058]
516679  TPCN2; two pore channel protein 2 [KO:K14077]
517688  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
517901  [KO:K04282]
518025  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
518117  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
518283  PTAFR; platelet-activating factor receptor [KO:K04279]
519037  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
520277  CALM3; calmodulin-3 [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
520498  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
521257  HRH2; histamine H2 receptor isoform X4 [KO:K04150]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
522170  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
522419  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
523484  [KO:K04161]
524212  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
524810  [KO:K06856]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
525504  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
526211  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6 [KO:K13755] [EC:3.1.4.17]
526221  DRD5; D(1B) dopamine receptor [KO:K05840]
526379  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
526585  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
526873  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
527499  P2RX2; P2X purinoceptor 2 [KO:K05216]
528416  NTSR1; neurotensin receptor type 1 [KO:K04211]
528555  CASQ2; calsequestrin-2 [KO:K23445]
529760  ADORA2B; adenosine receptor A2b [KO:K04267]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
530468  P2RX3; P2X purinoceptor 3 [KO:K05217]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
532029  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
532119  BDKRB1; B1 bradykinin receptor [KO:K03915]
532671  MCOLN2; mucolipin-2 [KO:K04993]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
532784  GRPR; gastrin-releasing peptide receptor [KO:K04169]
533103  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
533378  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
534051  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
534061  TRDN; triadin isoform X49 [KO:K23449]
534816  STIM1; stromal interaction molecule 1 precursor [KO:K16059]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
535158  GRIN2C; glutamate receptor ionotropic, NMDA 2C precursor [KO:K05211]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
535881  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
536132  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
536656  MCU; calcium uniporter protein, mitochondrial precursor [KO:K20858]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
537376  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
537804  GRIN2B; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
538439  AVPR1A; vasopressin V1a receptor [KO:K04226]
538510  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
538783  TBXA2R; thromboxane A2 receptor [KO:K04264]
538896  BDKRB2; B2 bradykinin receptor [KO:K03916]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
539126  NTRK3; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
539543  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
539899  RYR3; ryanodine receptor 3 [KO:K04963]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
540307  SLC8A3; sodium/calcium exchanger 3 precursor [KO:K05849]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
540387  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
540388  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
540485  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
540568  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
540682  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
540771  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
540877  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
541008  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
541168  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
541200  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
541299  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
613800  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
615008  C6H4orf3; uncharacterized protein C4orf3 homolog isoform X2 [KO:K26467]
615428  TNNC2; troponin C, skeletal muscle [KO:K12042]
615813  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
616000  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
617095  CALM1; calmodulin-1 [KO:K02183]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
617610  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein precursor [KO:K23450]
617828  ADORA2A; adenosine receptor A2a [KO:K04266]
618181  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
618262  P2RX6; P2X purinoceptor 6 isoform X2 [KO:K05221]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
618605  SPHK1; sphingosine kinase 1 isoform X3 [KO:K04718] [EC:2.7.1.91]
782045  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
785655  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
787122  [KO:K05863]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
bta04010  MAPK signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04210  Apoptosis
bta04720  Long-term potentiation
bta04730  Long-term depression
KO pathway
ko04020   

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