KEGG   PATHWAY: bta04062
Entry
bta04062                    Pathway                                
Name
Chemokine signaling pathway - Bos taurus (cow)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
bta04062  Chemokine signaling pathway
bta04062

Other DBs
GO: 0070098
Organism
Bos taurus (cow) [GN:bta]
Gene
100124525  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100140488  CCL17; C-C motif chemokine 17 [KO:K21083]
100295210  XCL2; lymphotactin [KO:K05507]
100297044  [KO:K05408]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100847184  [KO:K02833]
101902682  CCL27; C-C motif chemokine 27 [KO:K16598]
101905399  [KO:K04368] [EC:2.7.12.2]
104968964  [KO:K04542]
107131173  WAS; actin nucleation-promoting factor WAS [KO:K05747]
280814  HCK; tyrosine-protein kinase HCK isoform 2 [KO:K08893] [EC:2.7.10.2]
280828  CXCL8; interleukin-8 precursor [KO:K10030]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281043  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
281044  CCL8; C-C motif chemokine 8 precursor [KO:K16596]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
281212  GRO1; growth-regulated protein homolog alpha precursor [KO:K05505]
281214  CXCL2; growth-regulated protein homolog gamma precursor [KO:K05505]
281345  NCF1; neutrophil cytosol factor 1 [KO:K08011]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281457  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
281637  ARRB1; beta-arrestin-1 [KO:K04439]
281638  ARRB2; beta-arrestin-2 [KO:K04439]
281666  CCL20; C-C motif chemokine 20 precursor [KO:K14625]
281735  CXCL5; C-X-C motif chemokine 6 precursor [KO:K05506]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
281801  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
281802  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
281863  CXCR1; C-X-C chemokine receptor type 2 [KO:K04175]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
282031  RAP1A; ras-related protein Rap-1A [KO:K04353]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
282136  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
282170  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282376  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
282682  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
286877  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
319096  XCL1; lymphotactin precursor [KO:K05507]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327708  RAP1B; ras-related protein Rap-1b [KO:K07836]
327712  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
338049  RHOA; transforming protein RhoA [KO:K04513]
404072  CCL11; eotaxin precursor [KO:K16597]
407771  CCR1; C-C chemokine receptor type 1 [KO:K04176]
407772  CCR8; C-C chemokine receptor type 8 [KO:K04183]
408018  CCR3; C-C chemokine receptor type 3 [KO:K04178]
408019  CCR4; C-C chemokine receptor type 4 [KO:K04179]
414347  CCL4; C-C motif chemokine 4 precursor [KO:K12964]
497017  CCR5; C-C chemokine receptor type 5 [KO:K04180]
497018  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
497021  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
505708  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
506322  NRAS; GTPase NRas [KO:K07828]
506807  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
507196  SHC1; SHC-transforming protein 1 isoform b [KO:K06279]
507790  PF4; platelet factor 4 precursor [KO:K05407]
508233  RELA; transcription factor p65 [KO:K04735]
508387  CCL26; C-C motif chemokine 26 precursor [KO:K21096]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
508666  [KO:K05511]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
508933  [KO:K16598]
509167  CCL19; C-C motif chemokine 19 precursor [KO:K05512]
509821  ELMO1; engulfment and cell motility protein 1 isoform 2 [KO:K12366]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
510083  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
510668  CCR7; C-C chemokine receptor type 7 precursor [KO:K04182]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
511112  CCL21; C-C motif chemokine 21 precursor [KO:K16062]
511671  CXCL16; C-X-C motif chemokine 16 precursor [KO:K10035]
511674  CXCL13; C-X-C motif chemokine 13 precursor [KO:K10032]
511771  CXCL14; C-X-C motif chemokine 14 precursor [KO:K10033]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
512056  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
512489  GRK4; G protein-coupled receptor kinase 4 isoform X3 [KO:K08291] [EC:2.7.11.16]
512696  SHC3; SHC-transforming protein 3 isoform X3 [KO:K17448]
512841  CRK; adapter molecule crk [KO:K04438]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
513990  CXCL9; C-X-C motif chemokine 9 precursor [KO:K05416]
515621  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
515718  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
516104  CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672]
516133  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
517354  CX3CL1; fractalkine isoform X1 [KO:K05508]
517456  PXN; paxillin isoform X3 [KO:K05760]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
518180  CRKL; crk-like protein [KO:K04438]
519716  CCR6; C-C chemokine receptor type 6 [KO:K04181]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521413  GRK6; G protein-coupled receptor kinase 6 isoform 1 [KO:K08291] [EC:2.7.11.16]
521961  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
522311  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
524734  SHC4; SHC-transforming protein 4 [KO:K17449]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
525408  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
525415  [KO:K05408]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
527410  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
527550  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
527964  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
529196  [KO:K04176]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
530001  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
530951  CCR9; C-C chemokine receptor type 9 [KO:K04184]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533455  SHC2; SHC-transforming protein 2 [KO:K17447]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
534996  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535328  CCL28; C-C motif chemokine 28 precursor [KO:K05513]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
535530  FOXO3; forkhead box protein O3 [KO:K09408]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
536517  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
536561  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
538276  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
539002  CCR2; C-C chemokine receptor type 2 [KO:K04177]
539108  CCR10; C-C chemokine receptor type 10 [KO:K04185]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
541008  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
541140  KRAS; GTPase KRas [KO:K07827]
613667  CXCL3; chemokine (C-X-C motif) ligand 3 precursor [KO:K05505]
613723  PPBP; platelet basic protein [KO:K10029]
613811  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
614838  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
615107  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
615986  CCL25; C-C motif chemokine 25 precursor [KO:K13072]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616364  [KO:K05408]
616723  CCL14; C-C motif chemokine 14 precursor [KO:K21092]
616732  CCL16; C-C motif chemokine 16 [KO:K21093]
616996  CCL22; C-C motif chemokine 22 precursor [KO:K21095]
617258  CCL24; C-C motif chemokine 24 precursor [KO:K21097]
617345  VAV1; proto-oncogene vav [KO:K05730]
617880  XCR1; chemokine XC receptor 1 [KO:K04193]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
782719  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
786156  CCL1; C-C motif chemokine 1 [KO:K05514]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
789148  [KO:K07836]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
bta04010  MAPK signaling pathway
bta04060  Cytokine-cytokine receptor interaction
bta04120  Ubiquitin mediated proteolysis
bta04630  JAK-STAT signaling pathway
bta04670  Leukocyte transendothelial migration
bta04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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