KEGG   PATHWAY: bta04062
Entry
bta04062                    Pathway                                
Name
Chemokine signaling pathway - Bos taurus (cow)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
bta04062  Chemokine signaling pathway
bta04062

Other DBs
GO: 0070098
Organism
Bos taurus (cow) [GN:bta]
Gene
281212  GRO1; growth-regulated protein homolog alpha precursor [KO:K05505]
281214  CXCL2; growth-regulated protein homolog gamma precursor [KO:K05505]
613667  CXCL3; chemokine (C-X-C motif) ligand 3 precursor [KO:K05505]
281735  CXCL5; C-X-C motif chemokine 6 precursor [KO:K05506]
613723  PPBP; platelet basic protein [KO:K10029]
280828  CXCL8; interleukin-8 precursor [KO:K10030]
513990  CXCL9; C-X-C motif chemokine 9 precursor [KO:K05416]
615107  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
516104  CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672]
613811  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
511674  CXCL13; C-X-C motif chemokine 13 precursor [KO:K10032]
511671  CXCL16; C-X-C motif chemokine 16 precursor [KO:K10035]
507790  PF4; platelet factor 4 precursor [KO:K05407]
511771  CXCL14; C-X-C motif chemokine 14 precursor [KO:K10033]
319096  XCL1; lymphotactin precursor [KO:K05507]
100295210  XCL2; lymphotactin [KO:K22675]
517354  CX3CL1; fractalkine isoform X1 [KO:K05508]
786156  CCL1; C-C motif chemokine 1 [KO:K05514]
281043  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
282170  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
525415  C-C motif chemokine 3 [KO:K05408]
616364  C-C motif chemokine 3 [KO:K05408]
100297044  C-C motif chemokine 14 [KO:K05408]
414347  CCL4; C-C motif chemokine 4 precursor [KO:K12964]
327712  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
281044  CCL8; C-C motif chemokine 8 precursor [KO:K16596]
404072  CCL11; eotaxin precursor [KO:K16597]
616723  CCL14; C-C motif chemokine 14 precursor [KO:K21092]
508666  C-C motif chemokine 23 precursor [KO:K05511]
616732  CCL16; C-C motif chemokine 16 [KO:K21093]
100140488  CCL17; C-C motif chemokine 17 [KO:K21083]
509167  CCL19; C-C motif chemokine 19 precursor [KO:K05512]
281666  CCL20; C-C motif chemokine 20 precursor [KO:K14625]
511112  CCL21; C-C motif chemokine 21 precursor [KO:K16062]
616996  CCL22; C-C motif chemokine 22 precursor [KO:K21095]
617258  CCL24; C-C motif chemokine 24 precursor [KO:K21097]
615986  CCL25; C-C motif chemokine 25 precursor [KO:K13072]
508387  CCL26; C-C motif chemokine 26 precursor [KO:K21096]
508933  uncharacterized protein LOC508933 [KO:K16598]
101902682  CCL27; C-C motif chemokine 27 [KO:K16598]
535328  CCL28; C-C motif chemokine 28 precursor [KO:K05513]
782719  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
281863  CXCR1; C-X-C chemokine receptor type 2 [KO:K04175]
497018  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
497021  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
506807  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
617880  XCR1; chemokine XC receptor 1 [KO:K04193]
100124525  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
407772  CCR8; C-C chemokine receptor type 8 [KO:K04183]
519716  CCR6; C-C chemokine receptor type 6 [KO:K04181]
530951  CCR9; C-C chemokine receptor type 9 [KO:K04184]
408019  CCR4; C-C chemokine receptor type 4 [KO:K04179]
510668  CCR7; C-C chemokine receptor type 7 precursor [KO:K04182]
539002  CCR2; C-C chemokine receptor type 2 [KO:K04177]
497017  CCR5; C-C chemokine receptor type 5 [KO:K04180]
407771  CCR1; C-C chemokine receptor type 1 [KO:K04176]
529196  C-C chemokine receptor type 1-like [KO:K04176]
408018  CCR3; C-C chemokine receptor type 3 [KO:K04178]
539108  CCR10; C-C chemokine receptor type 10 [KO:K04185]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
538276  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
282376  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
534996  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
280814  HCK; tyrosine-protein kinase HCK isoform 2 [KO:K08893] [EC:2.7.10.2]
516133  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
507196  SHC1; SHC-transforming protein 1 isoform b [KO:K06279]
533455  SHC2; SHC-transforming protein 2 [KO:K17447]
512696  SHC3; SHC-transforming protein 3 isoform X3 [KO:K17448]
524734  SHC4; SHC-transforming protein 4 [KO:K17449]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
530001  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
614838  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
515621  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
286877  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535530  FOXO3; forkhead box protein O3 [KO:K09408]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
525408  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
508233  RELA; transcription factor p65 [KO:K04735]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
536561  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
522311  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
521961  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
617345  VAV1; proto-oncogene vav [KO:K05730]
515718  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
107131173  WAS; actin nucleation-promoting factor WAS [KO:K05747]
338049  RHOA; transforming protein RhoA [KO:K04513]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104968964  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
527410  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
509821  ELMO1; engulfment and cell motility protein 1 isoform 2 [KO:K12366]
510083  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
517456  PXN; paxillin isoform X3 [KO:K05760]
527550  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
512841  CRK; adapter molecule crk [KO:K04438]
518180  CRKL; crk-like protein [KO:K04438]
541008  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
512056  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
282031  RAP1A; ras-related protein Rap-1A [KO:K04353]
327708  RAP1B; ras-related protein Rap-1b [KO:K07836]
789148  ras-related protein Rap-1b [KO:K07836]
527964  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
536517  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
505708  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
281345  NCF1; neutrophil cytosol factor 1 [KO:K08011]
281457  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
281802  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
282136  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
282682  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
281801  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
512489  GRK4; G protein-coupled receptor kinase 4 isoform X3 [KO:K08291] [EC:2.7.11.16]
521413  GRK6; G protein-coupled receptor kinase 6 isoform 1 [KO:K08291] [EC:2.7.11.16]
281637  ARRB1; beta-arrestin-1 [KO:K04439]
281638  ARRB2; beta-arrestin-2 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
bta04010  MAPK signaling pathway
bta04060  Cytokine-cytokine receptor interaction
bta04120  Ubiquitin mediated proteolysis
bta04630  JAK-STAT signaling pathway
bta04670  Leukocyte transendothelial migration
bta04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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