KEGG   PATHWAY: bta04142
Entry
bta04142                    Pathway                                
Name
Lysosome - Bos taurus (cow)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bta04142  Lysosome
bta04142

Other DBs
GO: 0005764
Organism
Bos taurus (cow) [GN:bta]
Gene
338038  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
286768  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
518974  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
513684  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
282148  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
511839  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
282657  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
782343  LOW QUALITY PROTEIN: V-type proton ATPase subunit H-like [KO:K02144]
327687  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
550622  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
505684  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
534524  DMXL1; dmX-like protein 1 isoform X7 [KO:K24155]
782535  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
536469  WDR7; WD repeat-containing protein 7 [KO:K24738]
541071  NCOA7; nuclear receptor coactivator 7 isoform X7 [KO:K25442]
518169  CTSA; lysosomal protective protein precursor [KO:K13289] [EC:3.4.16.5]
281105  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
352958  CTSC; dipeptidyl peptidase 1 precursor [KO:K01275] [EC:3.4.14.1]
282883  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
509715  CTSF; cathepsin F precursor [KO:K01373] [EC:3.4.22.41]
505658  cathepsin G isoform X1 [KO:K01319] [EC:3.4.21.20]
509956  cathepsin G [KO:K01319] [EC:3.4.21.20]
510524  CTSH; pro-cathepsin H precursor [KO:K01366] [EC:3.4.22.16]
513038  CTSK; cathepsin K precursor [KO:K01371] [EC:3.4.22.38]
281108  CTSV; cathepsin L2 precursor [KO:K01365] [EC:3.4.22.15]
515200  CTSL; procathepsin L precursor [KO:K01365] [EC:3.4.22.15]
616804  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
327711  CTSS; cathepsin S precursor [KO:K01368] [EC:3.4.22.27]
510967  CTSW; cathepsin W precursor [KO:K08569] [EC:3.4.22.-]
404187  CTSZ; cathepsin Z precursor [KO:K08568] [EC:3.4.18.1]
539259  NAPSA; napsin-A isoform X2 [KO:K08565] [EC:3.4.23.-]
281281  LGMN; legumain precursor [KO:K01369] [EC:3.4.22.34]
515575  TPP1; tripeptidyl-peptidase 1 precursor [KO:K01279] [EC:3.4.14.9]
532742  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
507188  GLB1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
280798  GAA; lysosomal alpha-glucosidase precursor [KO:K12316] [EC:3.2.1.20]
537087  GBA1; lysosomal acid glucosylceramidase precursor [KO:K01201] [EC:3.2.1.45]
511050  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
533357  NAGA; alpha-N-acetylgalactosaminidase precursor [KO:K01204] [EC:3.2.1.49]
789125  NAGLU; alpha-N-acetylglucosaminidase precursor [KO:K01205] [EC:3.2.1.50]
533428  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
515687  GUSB; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
101904377  LOW QUALITY PROTEIN: beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
515729  FUCA2; plasma alpha-L-fucosidase precursor [KO:K01206] [EC:3.2.1.51]
509522  FUCA1; tissue alpha-L-fucosidase precursor [KO:K01206] [EC:3.2.1.51]
504468  HEXA; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
786974  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
618571  HEXB; beta-hexosaminidase subunit beta preproprotein [KO:K12373] [EC:3.2.1.52]
281909  MANBA; beta-mannosidase precursor [KO:K01192] [EC:3.2.1.25]
282272  MAN2B1; lysosomal alpha-mannosidase precursor [KO:K12311] [EC:3.2.1.24]
505554  NEU1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
353352  SPAM1; sperm adhesion molecule 1 precursor [KO:K01197] [EC:3.2.1.35]
281838  HYAL2; hyaluronidase-2 precursor [KO:K01197] [EC:3.2.1.35]
509761  hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
515397  HYAL1; hyaluronidase-1 precursor [KO:K01197] [EC:3.2.1.35]
616562  HYAL3; hyaluronidase-3 precursor [KO:K01197] [EC:3.2.1.35]
527125  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
518161  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
505514  ARSA; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
538401  ARSB; arylsulfatase B precursor [KO:K01135] [EC:3.1.6.12]
513067  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
515809  GALNS; N-acetylgalactosamine-6-sulfatase precursor [KO:K01132] [EC:3.1.6.4]
512444  GNS; N-acetylglucosamine-6-sulfatase precursor [KO:K01137] [EC:3.1.6.14]
541272  IDS; iduronate 2-sulfatase precursor [KO:K01136] [EC:3.1.6.13]
535442  SGSH; N-sulphoglucosamine sulphohydrolase precursor [KO:K01565] [EC:3.10.1.1]
100125267  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase precursor [KO:K01052] [EC:3.1.1.13]
282271  PLA2G15; phospholipase A2 group XV precursor [KO:K06129] [EC:3.1.1.5]
282218  DNASE2; deoxyribonuclease-2-alpha precursor [KO:K01158] [EC:3.1.22.1]
525117  DNASE2B; deoxyribonuclease-2-beta precursor [KO:K01158] [EC:3.1.22.1]
535407  ACP2; lysosomal acid phosphatase isoform 1 precursor [KO:K14410] [EC:3.1.3.2]
517002  ACP5; tartrate-resistant acid phosphatase type 5 precursor [KO:K14379] [EC:3.1.3.2]
505097  SMPD1; sphingomyelin phosphodiesterase precursor [KO:K12350] [EC:3.1.4.12]
510620  ASAH1; acid ceramidase precursor [KO:K12348] [EC:3.5.1.23]
511345  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
281433  PSAP; prosaposin precursor [KO:K12382]
529295  PSAPL1; proactivator polypeptide-like 1 precursor [KO:K12382]
504524  GM2A; ganglioside GM2 activator precursor [KO:K12383]
281421  PPT1; palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
516797  PPT2; lysosomal thioesterase PPT2 precursor [KO:K01074] [EC:3.1.2.22]
281897  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
529148  LAMP2; lysosome-associated membrane glycoprotein 2 isoform 2 precursor [KO:K06528]
531327  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
504960  CD68; macrosialin precursor [KO:K06501]
404156  CD63; CD63 antigen [KO:K06497]
533177  SCARB2; lysosome membrane protein 2 precursor [KO:K12384]
286772  NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385]
280815  NPC2; NPC intracellular cholesterol transporter 2 precursor [KO:K13443]
613527  CTNS; cystinosin precursor [KO:K12386]
530164  SLC17A5; sialin [KO:K12301]
282470  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
521189  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
112441543  natural resistance-associated macrophage protein 2-like [KO:K21398]
512464  solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2-like [KO:K21398]
404155  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
404135  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
512361  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
100299651  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
529923  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
509820  CD164; sialomucin core protein 24 precursor [KO:K06546]
531411  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
511591  SORT1; sortilin isoform X3 [KO:K12388]
504799  CLN3; battenin [KO:K12389]
529186  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
515944  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
511607  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
536435  SUMF1; formylglycine-generating enzyme precursor [KO:K13444] [EC:1.8.3.7]
509610  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
508713  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
100138633  N-acetylglucosamine-1-phosphotransferase subunit gamma-like [KO:K10087]
515935  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor [KO:K01125] [EC:3.1.4.45]
281849  IGF2R; cation-independent mannose-6-phosphate receptor precursor [KO:K06564]
281291  M6PR; cation-dependent mannose-6-phosphate receptor precursor [KO:K10089]
281078  CLTA; clathrin light chain A [KO:K04644]
281698  CLTB; clathrin light chain B [KO:K04645]
281080  CLTC; clathrin heavy chain 1 [KO:K04646]
507677  AP1G1; AP-1 complex subunit gamma-1 [KO:K12391]
100126076  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
506192  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
504310  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
515766  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
616331  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
768053  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
540693  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
281023  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
767602  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
784163  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
509427  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
514761  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
508867  AP3S2; AP-3 complex subunit sigma-2 [KO:K12399]
536359  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
536144  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
512078  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
768040  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
618267  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
510539  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
534634  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
517031  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
505738  MCOLN1; mucolipin-1 isoform 2 [KO:K04992]
520564  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
101906055  LITAFD; lITAF domain-containing protein isoform X1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bta00511  Other glycan degradation
bta00531  Glycosaminoglycan degradation
bta04130  SNARE interactions in vesicular transport
bta04140  Autophagy - animal
bta04144  Endocytosis
KO pathway
ko04142   
LinkDB

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