KEGG   PATHWAY: bta04510
Entry
bta04510                    Pathway                                
Name
Focal adhesion - Bos taurus (cow)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bta04510  Focal adhesion
bta04510

Other DBs
GO: 0005925
Organism
Bos taurus (cow) [GN:bta]
Gene
100125224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100138102  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100138434  LAMA2; laminin subunit alpha-2 [KO:K05637]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100336873  LAMA3; laminin subunit alpha-3 isoform X4 [KO:K06240]
100847184  [KO:K02833]
101905053  [KO:K16060]
101905399  [KO:K04368] [EC:2.7.12.2]
107131237  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
280794  FN1; fibronectin precursor [KO:K05717]
280831  JUN; transcription factor Jun [KO:K04448]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
280894  PGF; placenta growth factor precursor [KO:K16859]
280958  VWF; von Willebrand factor precursor [KO:K03900]
280979  ACTB; actin, cytoplasmic 1 [KO:K05692]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
281040  CAV1; caveolin-1 [KO:K06278]
281069  CHAD; chondroadherin precursor [KO:K06248]
281088  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
281165  FLNA; filamin-A [KO:K04437]
281233  IBSP; bone sialoprotein 2 precursor [KO:K06253]
281239  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281450  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
281499  SPP1; osteopontin precursor [KO:K06250]
281530  THBS1; thrombospondin-1 precursor [KO:K16857]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281647  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
281662  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
281848  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
281873  ITGA5; integrin alpha-5 [KO:K06484]
281875  ITGAV; integrin alpha-V precursor [KO:K06487]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282031  RAP1A; ras-related protein Rap-1A [KO:K04353]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
282187  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
282188  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
282191  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
282194  COL6A2; collagen alpha-2(VI) chain precursor [KO:K06238]
282195  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282318  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282564  ITGB5; integrin beta-5 precursor [KO:K06588]
282642  ITGB3; integrin beta-3 precursor [KO:K06493]
282644  ITGB6; integrin beta-6 precursor [KO:K06589]
282654  TNXB; tenascin-X precursor [KO:K06252]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
282882  ITGA4; integrin alpha-4 precursor [KO:K06483]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
317711  COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327708  RAP1B; ras-related protein Rap-1b [KO:K07836]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
338037  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
338049  RHOA; transforming protein RhoA [KO:K04513]
338092  THBS2; thrombospondin-2 precursor [KO:K04659]
404122  ACTG1; actin, cytoplasmic 2 [KO:K05692]
407107  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
407142  COL2A1; collagen alpha-1(II) chain isoform 1 preproprotein [KO:K19719]
407170  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
493642  CAV2; caveolin-2 [KO:K12958]
503620  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
504323  THBS3; thrombospondin-3 precursor [KO:K04659]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
505519  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
505942  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
505964  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
506387  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
506526  ITGA10; integrin alpha-10 precursor [KO:K06586]
506751  LAMA5; laminin subunit alpha-5 [KO:K06240]
506953  ITGA7; integrin alpha-7 [KO:K06583]
506995  ITGB4; integrin beta-4 precursor [KO:K06525]
507196  SHC1; SHC-transforming protein 1 isoform b [KO:K06279]
507525  VTN; vitronectin precursor [KO:K06251]
507667  EMP2; epithelial membrane protein 2 precursor [KO:K26256]
508257  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
508632  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
508819  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
511043  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
511422  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
511602  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
511976  ITGA8; integrin alpha-8 [KO:K06584]
512431  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
512696  SHC3; SHC-transforming protein 3 isoform X3 [KO:K17448]
512841  CRK; adapter molecule crk [KO:K04438]
513432  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
513673  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
514031  ITGB7; integrin beta-7 precursor [KO:K06590]
514106  MYL11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
514386  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
514902  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
515718  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
516175  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
517433  TNN; tenascin-N precursor [KO:K06252]
517456  PXN; paxillin isoform X3 [KO:K05760]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
518025  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
518180  CRKL; crk-like protein [KO:K04438]
518914  LAMC3; laminin subunit gamma-3 [KO:K06247]
520030  LAMB1; laminin subunit beta-1 precursor [KO:K05636]
520039  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
520167  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
520454  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521961  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
522269  ACTN4; alpha-actinin-4 [KO:K05699]
523526  COL4A6; collagen alpha-6(IV) chain isoform X3 [KO:K06237]
523755  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
524734  SHC4; SHC-transforming protein 4 [KO:K17449]
524770  ACTN1; alpha-actinin-1 [KO:K05699]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
526379  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
526409  TNR; tenascin-R precursor [KO:K06252]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
527263  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
527550  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
528252  TLN2; talin-2 isoform X1 [KO:K06271]
529670  LAMA4; laminin subunit alpha-4 precursor [KO:K06241]
529939  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
530102  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
530599  [KO:K06243]
530657  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
531505  MYL12A; myosin regulatory light polypeptide 9 [KO:K12757]
532127  ITGA9; integrin alpha-9 precursor [KO:K06585]
532572  LAMC1; laminin subunit gamma-1 precursor [KO:K05635]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533378  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
533455  SHC2; SHC-transforming protein 2 [KO:K17447]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534526  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
535951  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
536286  ITGB8; integrin beta-8 precursor [KO:K06591]
537203  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
537654  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5 [KO:K00889] [EC:2.7.1.68]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
538606  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
538829  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
539003  CTNNB1; catenin beta-1 [KO:K02105]
539224  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
539314  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
539742  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
540207  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
540310  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
540664  TNC; tenascin precursor [KO:K06252]
540786  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
541281  THBS4; thrombospondin-4 precursor [KO:K04659]
613533  FLNB; filamin-B [KO:K27392]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
614055  MYL12B; myosin regulatory light chain 12B [KO:K12757]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
615310  CAV3; caveolin-3 [KO:K12959]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
615430  PARVA; alpha-parvin [KO:K06275]
616294  PARVB; beta-parvin [KO:K06275]
617345  VAV1; proto-oncogene vav [KO:K05730]
617357  MYL10; myosin regulatory light chain 10 [KO:K12756]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
768226  ZYX; zyxin [KO:K06273]
783470  TLN1; talin-1 [KO:K06271]
783645  VCL; vinculin [KO:K05700]
785805  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
786490  EMP1; epithelial membrane protein 1 [KO:K26255]
786565  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
786886  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
788978  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
789148  [KO:K07836]
789493  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
790892  PARVG; gamma-parvin [KO:K06275]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
bta04010  MAPK signaling pathway
bta04060  Cytokine-cytokine receptor interaction
bta04070  Phosphatidylinositol signaling system
bta04110  Cell cycle
bta04151  PI3K-Akt signaling pathway
bta04310  Wnt signaling pathway
bta04512  ECM-receptor interaction
bta04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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