KEGG   PATHWAY: bta04540
Entry
bta04540                    Pathway                                
Name
Gap junction - Bos taurus (cow)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bta04540  Gap junction
bta04540

Other DBs
GO: 0005921
Organism
Bos taurus (cow) [GN:bta]
Gene
281193  GJA1; gap junction alpha-1 protein [KO:K07372]
282577  GJD2; gap junction delta-2 protein [KO:K07373]
281136  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
504592  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
100295732  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
537703  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
404053  TUBA1A; tubulin alpha-1B chain [KO:K07374]
504244  TUBA1C; tubulin alpha-1C chain [KO:K07374]
534900  TUBA3E; tubulin alpha-3 chain [KO:K07374]
535605  TUBA1D; tubulin alpha-1D chain [KO:K07374]
768036  TUBA8; tubulin alpha-8 chain [KO:K07374]
777775  TUBA4A; tubulin alpha-4A chain [KO:K07374]
782966  tubulin alpha-1 chain [KO:K07374]
100141266  tubulin alpha-1C chain [KO:K07374]
539882  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100295712  tubulin alpha-3 chain isoform X1 [KO:K07374]
112443216  tubulin alpha-1C chain [KO:K07374]
539149  TUBB4B; tubulin beta-4B chain [KO:K07375]
533307  tubulin beta chain [KO:K07375]
534206  TUBB6; tubulin beta-6 chain [KO:K07375]
540236  TUBB4A; tubulin beta-4A chain [KO:K07375]
541271  TUBB1; tubulin beta-1 chain [KO:K07375]
615087  TUBB; tubulin beta-5 chain [KO:K07375]
281555  TUBB2B; tubulin beta-2B chain [KO:K07375]
768070  TUBB3; tubulin beta-3 chain [KO:K07375]
100295973  TUBB2A; tubulin beta-2A chain [KO:K07375]
523542  CSNK1D; casein kinase I isoform delta [KO:K08959] [EC:2.7.11.1]
281061  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
407102  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
281604  ADRB1; beta-1 adrenergic receptor [KO:K04141]
281125  DRD1; D(1A) dopamine receptor [KO:K04144]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281126  DRD2; D(2) dopamine receptor [KO:K04145]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
407230  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
407135  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
407134  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
540485  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
100336861  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
281788  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
281878  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
613600  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
281216  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
282433  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
112449027  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
282004  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
533330  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
bta04010  MAPK signaling pathway
bta04020  Calcium signaling pathway
bta04060  Cytokine-cytokine receptor interaction
bta04070  Phosphatidylinositol signaling system
bta04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
LinkDB

DBGET integrated database retrieval system