KEGG   PATHWAY: bta04714
Entry
bta04714                    Pathway                                
Name
Thermogenesis - Bos taurus (cow)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
bta04714  Thermogenesis
bta04714

Other DBs
GO: 1990845
Organism
Bos taurus (cow) [GN:bta]
Gene
100125416  ACTL6A; actin-like protein 6A [KO:K11340]
100126182  COX19; cytochrome c oxidase assembly protein COX19 [KO:K18183]
100137803  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X3 [KO:K22410] [EC:2.1.1.367]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100138312  ACSL3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100270792  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
100295228  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
100295800  COX17; cytochrome c oxidase copper chaperone [KO:K02260]
100296238  BMP8B; bone morphogenetic protein 8B [KO:K16622]
100296470  COA4; coiled-coil-helix-coiled-coil-helix domain-containing protein 8 [KO:K18177]
100297222  [KO:K00417]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100299449  CNR1; cannabinoid receptor 1 [KO:K04277]
100300550  COX7B; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100847184  [KO:K02833]
100848816  KDM3B; lysine-specific demethylase 3B isoform X2 [KO:K15601] [EC:1.14.11.65]
101902002  [KO:K02266]
101902937  [KO:K02272]
101903567  [KO:K02272]
101904690  [KO:K03945]
101905997  [KO:K02272]
101906178  [KO:K11352]
101906363  [KO:K03947]
101906743  [KO:K02272]
101906916  [KO:K02128]
101907294  [KO:K03959]
104972669  [KO:K18179]
107132076  [KO:K18161]
112447079  [KO:K02272]
132342342  [KO:K02268]
132343201  [KO:K02130]
132343467  [KO:K02135]
132343845  [KO:K02270]
132343906  [KO:K02270]
132344161  [KO:K02268]
132345003  [KO:K02135]
132345058  [KO:K02268]
132346172  [KO:K02270]
132346262  [KO:K03949]
280802  GCG; pro-glucagon precursor [KO:K05259]
280979  ACTB; actin, cytoplasmic 1 [KO:K05692]
281090  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
281091  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
281355  NPPA; natriuretic peptides A precursor [KO:K12334]
281480  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
281481  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor [KO:K00237]
281561  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
281570  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
281606  ADRB3; beta-3 adrenergic receptor [KO:K04143]
281640  ATP5PO; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
281715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
281742  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281993  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
282004  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
282199  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
282200  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
282289  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor [KO:K03967]
282290  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282324  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
282393  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
282394  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
282517  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
282578  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
282690  ATP5PF; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
282701  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
282710  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
286840  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
286879  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
286885  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
287012  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
287014  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
287020  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial precursor [KO:K00411] [EC:7.1.1.8]
287027  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
287327  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
288380  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
326346  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
327660  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
327665  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
327668  ATP5F1C; ATP synthase subunit gamma, mitochondrial precursor [KO:K02136]
327670  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
327673  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
327675  ATP5F1B; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
327680  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
327688  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
327690  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
327691  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
327696  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor [KO:K00236]
327697  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
327698  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
327701  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
327702  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
327704  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
327706  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
327710  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
327713  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
327714  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
327717  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
327718  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
3283877  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3283878  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3283879  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3283880  COX2; cytochrome c oxidase subunit II [KO:K02261]
3283881  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
3283882  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
3283883  COX3; cytochrome c oxidase subunit III [KO:K02262]
3283884  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3283885  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3283886  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3283887  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
3283888  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
3283889  CYTB; cytochrome b [KO:K00412]
337887  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
338040  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
338046  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
338053  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
338057  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
338060  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
338061  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
338063  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
338064  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
338065  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
338073  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
338079  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
338081  ATP5F1D; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
338084  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
338086  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial precursor [KO:K02270]
338446  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
404122  ACTG1; actin, cytoplasmic 2 [KO:K05692]
404161  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
404188  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
414274  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
444878  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
503554  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
504219  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
504290  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor [KO:K18164]
504476  ACTL6B; actin-like protein 6B [KO:K11652]
504502  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial precursor [KO:K08766] [EC:2.3.1.21]
504985  TSC2; tuberin isoform X9 [KO:K07207]
505229  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
505290  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
505736  COA1; cytochrome c oxidase assembly factor 1 [KO:K18173]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
506059  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
506322  NRAS; GTPase NRas [KO:K07828]
506492  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
506812  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
507056  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
507686  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
508493  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
508734  NPPB; natriuretic peptides B precursor [KO:K12335]
509060  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
509459  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
509827  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
510509  COX11; cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
511190  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
511440  COX10; protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
511961  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform 1 [KO:K07200]
511968  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
512500  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
512665  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
512953  [KO:K02132]
513010  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
513105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
513710  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
514159  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
514859  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
514925  KLB; beta-klotho precursor [KO:K22404]
515409  DPF1; zinc finger protein neuro-d4 [KO:K22198]
515696  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
516039  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
516925  COX18; mitochondrial inner membrane protein COX18 [KO:K17797]
517811  COX15; cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
517953  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
518758  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
519449  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
520518  COA7; cytochrome c oxidase assembly factor 7 [KO:K18180]
520598  PLIN1; perilipin-1 [KO:K08768]
521844  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
522045  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
522230  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial [KO:K18162] [EC:2.1.1.-]
523017  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor [KO:K18163]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
526227  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
528204  RHEB; GTP-binding protein Rheb [KO:K07208]
529566  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X5 [KO:K09048]
531747  [KO:K11265] [EC:4.6.1.1]
532997  KDM1A; lysine-specific histone demethylase 1A isoform X2 [KO:K11450] [EC:1.14.99.66]
533048  NPR1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
533232  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
533330  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
533440  TSC1; hamartin isoform X1 [KO:K07206]
533908  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
534107  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
534129  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
535236  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
535416  SIRT6; NAD-dependent protein deacylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
536073  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
536628  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X2 [KO:K01897] [EC:6.2.1.3]
537161  ACSL1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
537412  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [KO:K11648]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
538624  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
538954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
539832  COA3; cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
540176  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
540181  ARID1A; AT-rich interactive domain-containing protein 1A [KO:K11653]
540225  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial precursor [KO:K02270]
540404  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
540904  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
540910  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
541140  KRAS; GTPase KRas [KO:K07827]
541232  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
613541  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
613899  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
614700  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
614794  COA5; cytochrome c oxidase assembly factor 5 [KO:K18178]
615440  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
615660  COX20; protein FAM36A [KO:K18184]
615757  COX8B; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
615979  COX16; cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
616109  UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419]
616871  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
617230  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
618339  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
767916  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
767961  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
768048  COX14; cytochrome c oxidase assembly protein COX14 [KO:K18181]
768072  COA6; cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
777769  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
782486  [KO:K02268]
783202  [KO:K02273]
784521  [KO:K02991]
785086  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
787359  DPF3; zinc finger protein DPF3 isoform X3 [KO:K22198]
787914  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
788745  [KO:K02127]
788948  BMP8A; bone morphogenetic protein 8A precursor [KO:K16622]
789613  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
bta00020  Citrate cycle (TCA cycle)
bta00190  Oxidative phosphorylation
bta04010  MAPK signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04150  mTOR signaling pathway
bta04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   

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