KEGG   PATHWAY: bta04714
Entry
bta04714                    Pathway                                
Name
Thermogenesis - Bos taurus (cow)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
bta04714  Thermogenesis
bta04714

Other DBs
GO: 1990845
Organism
Bos taurus (cow) [GN:bta]
Gene
281606  ADRB3; beta-3 adrenergic receptor [KO:K04143]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
531747  adenylate cyclase type 10 isoform X7 [KO:K11265] [EC:4.6.1.1]
521844  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
281715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
513105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
513010  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
529566  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X5 [KO:K09048]
785086  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
534129  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100137803  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X3 [KO:K22410] [EC:2.1.1.367]
519449  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
532997  KDM1A; lysine-specific histone demethylase 1A isoform X2 [KO:K11450] [EC:1.14.99.66]
281561  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
536073  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
100848816  KDM3B; lysine-specific demethylase 3B isoform X2 [KO:K15601] [EC:1.14.11.65]
540904  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
414274  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
537412  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [KO:K11648]
522045  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
509060  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
533232  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
789613  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
777769  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
540910  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
404122  ACTG1; actin, cytoplasmic 2 [KO:K05692]
280979  ACTB; actin, cytoplasmic 1 [KO:K05692]
100125416  ACTL6A; actin-like protein 6A [KO:K11340]
504476  ACTL6B; actin-like protein 6B [KO:K11652]
540181  ARID1A; AT-rich interactive domain-containing protein 1A [KO:K11653]
505229  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
515409  DPF1; zinc finger protein neuro-d4 [KO:K22198]
787359  DPF3; zinc finger protein DPF3 isoform X3 [KO:K22198]
281993  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
516039  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
338446  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
509827  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
535416  SIRT6; NAD-dependent protein deacylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
520598  PLIN1; perilipin-1 [KO:K08768]
286879  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
508493  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
505290  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
538954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
540404  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
512665  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
534107  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
282324  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
504219  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
511961  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform 1 [KO:K07200]
280802  GCG; pro-glucagon precursor [KO:K05259]
100296238  BMP8B; bone morphogenetic protein 8B [KO:K16622]
788948  BMP8A; bone morphogenetic protein 8A precursor [KO:K16622]
100299449  CNR1; cannabinoid receptor 1 [KO:K04277]
281355  NPPA; natriuretic peptides A precursor [KO:K12334]
508734  NPPB; natriuretic peptides B precursor [KO:K12335]
533048  NPR1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
282004  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
533330  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
514925  KLB; beta-klotho precursor [KO:K22404]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
538624  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
533908  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
511190  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
526227  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
517953  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
533440  TSC1; hamartin isoform X1 [KO:K07206]
504985  TSC2; tuberin isoform X9 [KO:K07207]
528204  RHEB; GTP-binding protein Rheb [KO:K07208]
507056  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
535236  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
514859  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
787914  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
784521  small ribosomal subunit protein eS6-like [KO:K02991]
537161  ACSL1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
514159  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
536628  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X2 [KO:K01897] [EC:6.2.1.3]
506059  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
100138312  ACSL3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
3283877  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3283878  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3283884  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3283886  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3283885  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3283887  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
3283888  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
288380  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
327697  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
287327  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
327680  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
338057  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
327691  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
338079  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
287027  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
287014  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
282290  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
327717  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
327673  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101904690  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
327698  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
338064  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101906363  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
327704  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
613541  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
327714  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
132346262  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
327670  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
338063  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
327710  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
404188  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
338060  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
327702  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
326346  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
281742  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101906178  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
338084  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
327690  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
327713  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
338073  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101907294  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
327706  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
338061  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
327665  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
338065  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
282517  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
327660  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
327701  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
404161  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
282289  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor [KO:K03967]
338046  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
541232  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
767961  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
511968  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
615440  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
107132076  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4-like [KO:K18161]
522230  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial [KO:K18162] [EC:2.1.1.-]
523017  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor [KO:K18163]
504290  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor [KO:K18164]
100295228  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
281480  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
286840  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
327696  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor [KO:K00236]
281481  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor [KO:K00237]
287020  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial precursor [KO:K00411] [EC:7.1.1.8]
3283889  CYTB; cytochrome b [KO:K00412]
512500  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
282393  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
282394  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
613899  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
616871  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
100297222  cytochrome b-c1 complex subunit 7 [KO:K00417]
286885  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
616109  UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419]
281570  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
3283879  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3283880  COX2; cytochrome c oxidase subunit II [KO:K02261]
3283883  COX3; cytochrome c oxidase subunit III [KO:K02262]
281090  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
618339  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
444878  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
287012  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
282200  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
282199  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
101902002  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
503554  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
100270792  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
614700  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
782486  cytochrome c oxidase subunit VIc-like protein [KO:K02268]
132344161  cytochrome c oxidase subunit 6C-like [KO:K02268]
132342342  cytochrome c oxidase subunit 6C-like [KO:K02268]
132345058  cytochrome c oxidase subunit 6C-like [KO:K02268]
327688  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
338086  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial precursor [KO:K02270]
540225  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial precursor [KO:K02270]
132343906  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
132346172  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
132343845  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
100300550  COX7B; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
767916  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101902937  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101903567  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
327718  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101905997  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112447079  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101906743  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
281091  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
783202  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
615757  COX8B; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
100300759  uncharacterized protein LOC100300759 [KO:K02273]
511440  COX10; protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
510509  COX11; cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
768048  COX14; cytochrome c oxidase assembly protein COX14 [KO:K18181]
517811  COX15; cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
615979  COX16; cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
100295800  COX17; cytochrome c oxidase copper chaperone [KO:K02260]
516925  COX18; mitochondrial inner membrane protein COX18 [KO:K17797]
100126182  COX19; cytochrome c oxidase assembly protein COX19 [KO:K18183]
615660  COX20; protein FAM36A [KO:K18184]
505736  COA1; cytochrome c oxidase assembly factor 1 [KO:K18173]
539832  COA3; cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
100296470  COA4; coiled-coil-helix-coiled-coil-helix domain-containing protein 8 [KO:K18177]
614794  COA5; cytochrome c oxidase assembly factor 5 [KO:K18178]
768072  COA6; cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
104972669  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
520518  COA7; cytochrome c oxidase assembly factor 7 [KO:K18180]
282578  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
512953  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
327675  ATP5F1B; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
327668  ATP5F1C; ATP synthase subunit gamma, mitochondrial precursor [KO:K02136]
338081  ATP5F1D; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
617230  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
132343467  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
132345003  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
281640  ATP5PO; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
3283882  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
282701  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
788745  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
540176  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
337887  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
338053  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
101906916  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
282710  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
338040  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
506492  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
132343201  ATP synthase subunit f, mitochondrial-like [KO:K02130]
282690  ATP5PF; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
3283881  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
515696  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
504502  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial precursor [KO:K08766] [EC:2.3.1.21]
507686  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
518758  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
506812  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
509459  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
513710  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
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Nat Commun 6:7052 (2015)
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Related
pathway
bta00020  Citrate cycle (TCA cycle)
bta00190  Oxidative phosphorylation
bta04010  MAPK signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04150  mTOR signaling pathway
bta04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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