Entry Name Gastric acid secretion - Bos taurus (cow)
Description Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Bos taurus (cow) [GN:
bta ]
Gene 281665 CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195 ]
281685 CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131 ]
281790 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
281791 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
281793 GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
281878 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
281879 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
281883 KCNJ2; inward rectifier potassium channel 2 [KO:K04996 ]
281985 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
282162 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
282562 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
282590 KCNK2; potassium channel subfamily K member 2 [KO:K04913 ]
282598 ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539 ] [EC:7.2.2.13 ]
287026 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
317697 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
508888 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
515669 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
519758 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
522184 KCNJ15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
525109 KCNK10; potassium channel subfamily K member 10 [KO:K04920 ]
525416 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
530719 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
532713 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
532844 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
533343 KCNJ10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
536654 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
539250 KCNJ1; ATP-sensitive inward rectifier potassium channel 1 [KO:K04995 ]
539521 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
613890 KCNJ16; inward rectifier potassium channel 16 [KO:K05009 ]
617412 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
768025 KCNE2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
784876 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Schubert ML, Peura DA
Title Control of gastric acid secretion in health and disease.
Journal Reference Authors Urushidani T, Forte JG
Title Signal transduction and activation of acid secretion in the parietal cell.
Journal Reference Authors Yao X, Forte JG
Title Cell biology of acid secretion by the parietal cell.
Journal Reference Authors Heitzmann D, Warth R
Title No potassium, no acid: K+ channels and gastric acid secretion.
Journal Reference Authors Kopic S, Murek M, Geibel JP
Title Revisiting the parietal cell.
Journal Reference Authors Schubert ML
Title Gastric secretion.
Journal Reference Authors Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal J Physiol Pharmacol 56:507-30 (2005)
Reference Authors Forte JG, Zhu L
Title Apical recycling of the gastric parietal cell H,K-ATPase.
Journal Reference Authors Szaszak M, Christian F, Rosenthal W, Klussmann E
Title Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal Reference Authors Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal Related bta04974 Protein digestion and absorption
KO pathway 
