KEGG PATHWAY: cel04150

PATHWAY: cel04150

Entry

cel04150                    Pathway

Name

mTOR signaling pathway - Caenorhabditis elegans (nematode)

Description

The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.

Class

Environmental Information Processing; Signal transduction

Pathway map

cel04150

mTOR signaling pathway

Organism

Caenorhabditis elegans (nematode) [GN:cel]

Gene

CELE_B0261.2

let-363; Target of rapamycin homolog [KO:K07203] [EC:2.7.11.1]

CELE_B0334.8

age-1; Phosphatidylinositol 3-kinase age-1 [KO:K00922] [EC:2.7.1.153]

CELE_B0348.6

ife-3; Eukaryotic translation initiation factor 4E-3 [KO:K03259]

CELE_C05D9.5

ife-4; Eukaryotic translation initiation factor 4E-4 [KO:K03259]

CELE_C06H2.6

lmtr-3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 [KO:K04370]

CELE_C07H6.6

clk-2; Telomere length regulation protein clk-2 [KO:K11137]

CELE_C10C5.6

daf-15; Raptor N-terminal CASPase-like domain-containing protein [KO:K07204]

CELE_C10H11.8

mlst-8; Target of rapamycin complex subunit lst8 [KO:K08266]

CELE_C12D8.10

akt-1; Serine/threonine-protein kinase akt-1 [KO:K04456] [EC:2.7.11.1]

CELE_C14F5.5

sem-5; Sex muscle abnormal protein 5 [KO:K04364]

CELE_C17H12.14

vha-8; V-type proton ATPase subunit E [KO:K02150]

CELE_C27A2.6

dsh-2; DiSHevelled related [KO:K02353]

CELE_C34F11.9

dsh-1; DiSHevelled related [KO:K02353]

CELE_C44H4.6

C44H4.6; Protein kinase domain-containing protein [KO:K03083] [EC:2.7.11.26]

CELE_C54D1.3

ist-1; IRS-type PTB domain-containing protein [KO:K16172]

CELE_E01H11.1

pkc-2; Protein kinase C-like 2 [KO:K02677] [EC:2.7.11.13]

CELE_F13H10.3

F13H10.3; Sodium-coupled neutral amino acid transporter 9 homolog [KO:K14995]

CELE_F20B6.2

vha-12; V-type proton ATPase subunit B 1 [KO:K02147]

CELE_F22D3.2

flcn-1; Folliculin DENN domain-containing protein [KO:K09594]

CELE_F27E11.3

cfz-2; Frizzled-2 [KO:K02375]

CELE_F28H6.1

akt-2; Serine/threonine-protein kinase akt-2 [KO:K04456] [EC:2.7.11.1]

CELE_F29C12.3

rict-1; RICTOR_N domain-containing protein [KO:K08267]

CELE_F35H10.7

nprl-3; GATOR complex protein NPRL3 [KO:K20406]

CELE_F38E1.7

mom-2; Protein mom-2 [KO:K00408]

CELE_F43C1.2

mpk-1; Mitogen-activated protein kinase mpk-1 [KO:K04371] [EC:2.7.11.24]

CELE_F46F11.5

vha-10; putative V-type proton ATPase subunit G [KO:K02152]

CELE_F48E8.7

skpt-1; F-box domain-containing protein [KO:K03875]

CELE_F49E8.1

nprl-2; Nitrogen permease regulator 2 [KO:K20405]

CELE_F52E1.10

vha-18; putative V-type proton ATPase subunit H 1 [KO:K02144]

CELE_F53A2.6

ife-1; Eukaryotic translation initiation factor 4E-1 [KO:K03259]

CELE_F54C8.5

rheb-1; GTP-binding protein Rheb homolog 1 [KO:K07208]

CELE_F55H2.2

vha-14; V-type proton ATPase subunit D [KO:K02149]

CELE_H37A05.1

lpin-1; LNS2/PITP domain-containing protein [KO:K15728] [EC:3.1.3.4]

CELE_H42K12.1

pdk-1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]

CELE_K10B4.6

cwn-1; Protein Wnt-1 [KO:K00408]

CELE_PAR2.3

aak-1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]

CELE_R02E12.2

mop-25.1; uncharacterized protein [KO:K08272]

CELE_R03D7.5

gskl-1; Putative serine/threonine-protein kinase R03D7.5 [KO:K03083] [EC:2.7.11.26]

CELE_R04A9.4

ife-2; Eukaryotic translation initiation factor 4E-2 [KO:K03259]

CELE_R04A9.7

R04A9.7; Non-specific serine/threonine protein kinase [KO:K04688] [EC:2.7.11.1]

CELE_R10H10.7

R10H10.7; Non-specific serine/threonine protein kinase [KO:K20403]

CELE_R148.2

lmtr-5; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 [KO:K16344]

CELE_T01C8.1

aak-2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]

CELE_T01H8.1

rskn-1; Putative ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]

CELE_T04C4.1

fnip-2; UDENN FNIP1/2-type domain-containing protein [KO:K20401]

CELE_T07A9.6

daf-18; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]

CELE_T08A11.1

depd-5; DEP domain-containing protein [KO:K20404]

CELE_T14F9.1

vha-15; putative V-type proton ATPase subunit H 2 [KO:K02144]

CELE_T23D8.1

mom-5; Protein mom-5 [KO:K02432]

CELE_T24F1.1

raga-1; GTP-binding protein [KO:K16185]

CELE_T28F12.3

sos-1; Son of sevenless homolog [KO:K03099]

CELE_W08D2.1

egl-20; Protein Wnt [KO:K01558]

CELE_W10G6.2

sgk-1; Serine/threonine-protein kinase sgk-1 [KO:K13302] [EC:2.7.11.1]

CELE_Y110A7A.10

aap-1; SH2 domain-containing protein [KO:K02649]

CELE_Y110A7A.12

spe-5; V-type proton ATPase subunit B 2 [KO:K02147]

CELE_Y18D10A.5

gsk-3; Glycogen synthase kinase-3 [KO:K03083] [EC:2.7.11.26]

CELE_Y24F12A.2

ragc-1; Ras-related GTP-binding protein C [KO:K16186]

CELE_Y32H12A.8

Y32H12A.8; WDR59/RTC1-like RING zinc finger domain-containing protein [KO:K20408]

CELE_Y34D9B.1

mig-1; Frizzled-4 [KO:K02354]

CELE_Y38F2AL.3

vha-11; V-type proton ATPase subunit C [KO:K02148]

CELE_Y43F4B.4

npp-18; Nucleoporin SEH1 [KO:K14299]

CELE_Y47D3A.16

rsks-1; Ribosomal protein S6 kinase beta [KO:K04688] [EC:2.7.11.1]

CELE_Y49A3A.2

vha-13; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

CELE_Y51H4A.3

rho-1; Ras-like GTP-binding protein rhoA [KO:K04513]

CELE_Y52D3.1

strd-1; STE20-related kinase adapter protein strd-1 [KO:K08271]

CELE_Y53C12A.4

mop-25.2; MO25-like protein 2 [KO:K08272]

CELE_Y54E10BL.6

mek-2; Dual specificity mitogen-activated protein kinase kinase mek-2 [KO:K04368] [EC:2.7.12.2]

CELE_Y55D5A.5

daf-2; Insulin-like receptor subunit beta [KO:K04527] [EC:2.7.10.1]

CELE_Y57A10A.20

sinh-1; Stress-activated map kinase-interacting protein 1 homolog [KO:K20410]

CELE_Y57A10A.30

ife-5; Eukaryotic translation initiation factor 4E-5 [KO:K03259]

CELE_Y59A8B.14

par-4; Serine/threonine-protein kinase par-4 [KO:K07298] [EC:2.7.11.1]

CELE_Y60A3A.1

unc-51; Serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]

CELE_Y71A12B.1

rps-6; Small ribosomal subunit protein eS6 [KO:K02991]

CELE_Y71F9B.5

lin-17; Frizzled-4 [KO:K02842]

CELE_Y73B6A.5

lin-45; Raf homolog serine/threonine-protein kinase [KO:K04365] [EC:2.7.11.1]

CELE_Y77E11A.13

npp-20; Protein SEC13 homolog [KO:K14004]

CELE_Y97E10AR.7

lmtr-2; Ragulator complex protein LAMTOR2 homolog [KO:K20398]

CELE_ZK792.6

let-60; Ras protein let-60 [KO:K07827]

CELE_ZK970.4

vha-9; putative V-type proton ATPase subunit F [KO:K02151]

Compound

C00020

AMP

C00062

L-Arginine

C00123

L-Leucine

C05981

Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:27304501

Authors

Kennedy BK, Lamming DW

Title

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

Journal

Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009

Reference

PMID:24556838

Authors

Shimobayashi M, Hall MN

Title

Making new contacts: the mTOR network in metabolism and signalling crosstalk.

Journal

Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757

Reference

PMID:25242279

Authors

Huang K, Fingar DC

Title

Growing knowledge of the mTOR signaling network.

Journal

Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011

Reference

PMID:26269525

Authors

Bockaert J, Marin P

Title

mTOR in Brain Physiology and Pathologies.

Journal

Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014

Reference

PMID:26185979

Authors

Caron A, Richard D, Laplante M

Title

The Roles of mTOR Complexes in Lipid Metabolism.

Journal

Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355

Reference

PMID:26658722

Authors

Shimobayashi M, Hall MN

Title

Multiple amino acid sensing inputs to mTORC1.

Journal

Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146

Reference

PMID:24698685

Authors

Bar-Peled L, Sabatini DM

Title

Regulation of mTORC1 by amino acids.

Journal

Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003

Reference

PMID:26046644

Authors

Fingar DC

Title

Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.

Journal

Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029

Reference

PMID:26700098

Authors

Cai H, Dong LQ, Liu F

Title

Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.

Journal

Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011

Reference

PMID:24842496

Authors

Eyre TA, Collins GP, Goldstone AH, Cwynarski K

Title

Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.

Journal

Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945

Reference

PMID:23465396

Authors

Jewell JL, Guan KL

Title

Nutrient signaling to mTOR and cell growth.

Journal

Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004

Reference

PMID:23421405

Authors

Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB

Title

mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.

Journal

ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092

Reference

PMID:23694989

Authors

Kim SG, Buel GR, Blenis J

Title

Nutrient regulation of the mTOR complex 1 signaling pathway.

Journal

Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2

Reference

PMID:19812304

Authors

Laplante M, Sabatini DM

Title

mTOR signaling at a glance.

Journal

J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011

Reference

PMID:16756488

Authors

Alessi DR, Sakamoto K, Bayascas JR

Title

LKB1-dependent signaling pathways.

Journal

Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702

Reference

PMID:27027448

Authors

Dan HC, Antonia RJ, Baldwin AS

Title

PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.

Journal

Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383

Reference

PMID:28283069

Authors

Saxton RA, Sabatini DM

Title

mTOR Signaling in Growth, Metabolism, and Disease.

Journal

Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004

Related
pathway

cel00561

Glycerolipid metabolism

cel04140

Autophagy - animal

KO pathway

ko04150

DBGET integrated database retrieval system