KEGG   PATHWAY: cfa04062
Entry
cfa04062                    Pathway                                
Name
Chemokine signaling pathway - Canis lupus familiaris (dog)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
cfa04062  Chemokine signaling pathway
cfa04062

Other DBs
GO: 0070098
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100534634  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100683432  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100684309  CRK; adapter molecule crk isoform X8 [KO:K04438]
100684653  GRK6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
100686212  CCL22; C-C motif chemokine 22 [KO:K21095]
100686332  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100855806  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100856190  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100856339  [KO:K02649]
106557449  [KO:K05506]
106559217  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
106559760  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111098084  [KO:K16598]
119863873  [KO:K04545]
119863888  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119863891  [KO:K04189]
119866928  [KO:K04393]
119874472  [KO:K05505]
119876918  [KO:K05505]
403511  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
403522  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
403541  CCR4; C-C chemokine receptor type 4 [KO:K04179]
403556  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
403586  CCL17; C-C motif chemokine 17 precursor [KO:K21083]
403617  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
403850  CXCL8; interleukin-8 precursor [KO:K10030]
403859  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
403871  KRAS; GTPase KRas isoform X1 [KO:K07827]
403872  NRAS; GTPase NRas [KO:K07828]
403895  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
403912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
403928  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
403954  RHOA; transforming protein RhoA [KO:K04513]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
403981  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
442859  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
442957  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
445451  CCL13; C-C motif chemokine 13 precursor [KO:K16595]
445452  CCL24; C-C motif chemokine 24 precursor [KO:K21097]
445454  CCL27; C-C motif chemokine 27 precursor [KO:K16598]
448786  CCL4; C-C motif chemokine 4 precursor [KO:K12964]
448787  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
448788  CCL1; C-C motif chemokine 1 precursor [KO:K05514]
448789  CCL26; C-C motif chemokine 26 precursor [KO:K21096]
448790  CCL20; C-C motif chemokine 20 precursor [KO:K14625]
448792  CCL8; C-C motif chemokine 8 precursor [KO:K16596]
448793  CCL19; C-C motif chemokine 19 precursor [KO:K05512]
448795  CCL28; C-C motif chemokine 28 precursor [KO:K05513]
448796  CCL21; C-C motif chemokine 21 precursor [KO:K16062]
448798  CCL25; C-C motif chemokine 25 precursor [KO:K13072]
448802  CCR3; C-C chemokine receptor type 3 [KO:K04178]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
449622  CXCL12; stromal cell-derived factor 1 isoform 1 precursor [KO:K10031]
475108  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
475526  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
476034  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
476352  SHC3; SHC-transforming protein 3 [KO:K17448]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
477160  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
477625  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
477796  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
477886  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
477953  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
478227  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
478432  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
478575  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
478624  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
478905  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
478906  CXCR1; C-X-C chemokine receptor type 2 [KO:K04175]
479075  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
479577  PRKCZ; protein kinase C zeta type isoform X5 [KO:K18952] [EC:2.7.11.13]
479648  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X9 [KO:K05726]
479733  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
479921  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
479975  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
480181  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
480271  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
480291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
480600  [KO:K05408]
480601  [KO:K05408]
480602  CCL23; C-C motif chemokine 15 isoform X2 [KO:K05511]
480603  CCL14; C-C motif chemokine 14 [KO:K21092]
480604  CCL16; C-C motif chemokine 16 [KO:K21093]
481111  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
481271  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
481954  FOXO3; forkhead box protein O3 [KO:K09408]
482045  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
482196  PPBP; platelet basic protein precursor [KO:K10029]
482839  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
482970  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
482994  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
483225  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
483266  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289] [EC:2.7.1.153]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
483701  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
483729  RELA; transcription factor p65 isoform X2 [KO:K04735]
483763  BAD; bcl2-associated agonist of cell death [KO:K02158]
483783  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
484080  CCR6; C-C chemokine receptor type 6 [KO:K04181]
484185  JAK2; tyrosine-protein kinase JAK2 isoform X13 [KO:K04447] [EC:2.7.10.2]
484476  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
484519  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
484789  CCR5; C-C chemokine receptor type 5 [KO:K04180]
484790  CCR2; C-C chemokine receptor type 2 [KO:K04177]
484791  CCR1; C-C chemokine receptor type 1 [KO:K04176]
484792  XCR1; chemokine XC receptor 1 [KO:K04193]
484793  CCR9; C-C chemokine receptor type 9 [KO:K04184]
485016  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
485189  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
485557  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
485599  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
485600  CCR8; C-C chemokine receptor type 8 [KO:K04183]
485693  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
485773  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
485828  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
485864  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
485874  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
485917  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X8 [KO:K12365]
486102  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
486299  PXN; paxillin isoform X2 [KO:K05760]
486327  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
486915  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
487265  CX3CL1; fractalkine precursor [KO:K05508]
487289  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
487341  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
487546  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
487731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
488087  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
488449  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
489128  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
489159  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
489378  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
489692  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
489968  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
490031  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
490356  [KO:K05507]
490439  SHC1; SHC-transforming protein 1 [KO:K06279]
490682  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490967  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
490969  STAT5B; signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
491011  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
491148  CCL7; C-C motif chemokine 7 precursor [KO:K05509]
491867  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
491952  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
494005  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
607262  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
607357  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 isoform X5 [KO:K08041] [EC:4.6.1.1]
607513  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
607514  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
607528  CCR10; C-C chemokine receptor type 10 isoform X2 [KO:K04185]
607700  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
607885  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
608060  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
608125  CRKL; crk-like protein isoform X2 [KO:K04438]
608156  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
608225  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X5 [KO:K21290]
608623  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
608840  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
608981  RAP1B; ras-related protein Rap-1b [KO:K07836]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
610004  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
610078  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
610817  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
611002  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
611349  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
611810  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha isoform X2 [KO:K04630]
611955  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
612101  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
612139  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
612805  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
612913  ELMO1; engulfment and cell motility protein 1 isoform X4 [KO:K12366]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
cfa04010  MAPK signaling pathway
cfa04060  Cytokine-cytokine receptor interaction
cfa04120  Ubiquitin mediated proteolysis
cfa04630  JAK-STAT signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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