KEGG   PATHWAY: cfa04142
Entry
cfa04142                    Pathway                                
Name
Lysosome - Canis lupus familiaris (dog)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
cfa04142  Lysosome
cfa04142

Other DBs
GO: 0005764
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100505382  IDUA; alpha-L-iduronidase precursor [KO:K01217] [EC:3.2.1.76]
100684998  [KO:K12403]
100688000  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
100688895  [KO:K01365] [EC:3.4.22.15]
100855818  GM2A; ganglioside GM2 activator [KO:K12383]
100856090  CTNS; cystinosin isoform X1 [KO:K12386]
100856363  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
100856506  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
100856559  CLTA; clathrin light chain A isoform X4 [KO:K04644]
102153355  LITAFD; LITAF domain-containing protein isoform X1 [KO:K19363]
102156614  CTSV; procathepsin L [KO:K01365] [EC:3.4.22.15]
106559147  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
111095877  CD68; macrosialin [KO:K06501]
119871594  [KO:K19363]
119876012  [KO:K13443]
403400  CTSS; cathepsin S precursor [KO:K01368] [EC:3.4.22.27]
403403  PLA2G15; phospholipase A2 group XV precursor [KO:K06129] [EC:3.1.1.5]
403458  CTSC; dipeptidyl peptidase 1 precursor [KO:K01275] [EC:3.4.14.1]
403459  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
403698  NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385]
403707  SGSH; N-sulphoglucosamine sulphohydrolase precursor [KO:K01565] [EC:3.10.1.1]
403831  GUSB; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
403873  GLB1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
403916  GALC; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
403920  NPC2; NPC intracellular cholesterol transporter 2 precursor [KO:K13443]
403929  FUCA1; tissue alpha-L-fucosidase precursor [KO:K01206] [EC:3.2.1.51]
474391  CD63; CD63 antigen [KO:K06497]
474429  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
474457  ARSA; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
474631  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
474856  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
474969  SLC17A5; sialin isoform X2 [KO:K12301]
475020  CD164; sialomucin core protein 24 [KO:K06546]
475042  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
475211  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
475212  HYAL4; LOW QUALITY PROTEIN: hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
475316  PPT1; palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
475443  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
475638  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
475678  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
475983  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
476010  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
476086  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X2 [KO:K12307]
476191  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
476283  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
476406  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
476697  DNASE2; LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
476705  ACP5; tartrate-resistant acid phosphatase type 5 precursor [KO:K14379] [EC:3.1.3.2]
476750  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
476995  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528]
477456  ABCB9; ATP-binding cassette sub-family B member 9 isoform X2 [KO:K05656]
477568  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
477700  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
477929  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
478100  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
478304  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
478306  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
478435  SCARB2; lysosome membrane protein 2 isoform X2 [KO:K12384]
478909  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
479042  AP3S2; AP-3 complex subunit sigma-2 [KO:K12399]
479053  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
479065  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
479240  PSAP; prosaposin isoform X2 [KO:K12382]
479666  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
479685  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
479794  CLN3; battenin [KO:K12389]
479877  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
479915  SORT1; sortilin isoform X1 [KO:K12388]
479973  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
480232  LGMN; legumain isoform X9 [KO:K01369] [EC:3.4.22.34]
480253  AP1G2; AP-1 complex subunit gamma-like 2 isoform X5 [KO:K12391]
480283  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
480460  ARSG; arylsulfatase G precursor [KO:K12381] [EC:3.1.6.-]
480578  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
480669  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
481037  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
481226  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
481266  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X2 [KO:K12404]
481717  NEU1; sialidase-1 isoform X2 [KO:K01186] [EC:3.2.1.18]
482528  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661]
482665  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
482779  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
482833  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X2 [KO:K10532] [EC:2.3.1.78]
482841  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
482897  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
483125  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
483310  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
483352  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
483662  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
483691  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
483725  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
484016  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
484067  IGF2R; cation-independent mannose-6-phosphate receptor precursor [KO:K06564]
484140  CTSL3; procathepsin L [KO:K01365] [EC:3.4.22.15]
484681  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
484760  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
484932  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
485334  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
485337  TPP1; tripeptidyl-peptidase 1 precursor [KO:K01279] [EC:3.4.14.9]
485498  CLN5; ceroid-lipofuscinosis neuronal protein 5 precursor [KO:K12390]
486077  CTSB; cathepsin B isoform X2 [KO:K01363] [EC:3.4.22.1]
486117  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
486245  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X2 [KO:K02154]
486344  AP1B1; AP-1 complex subunit beta-1 isoform X2 [KO:K12392]
486543  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
486953  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
487324  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
487633  HEXA; beta-hexosaminidase subunit alpha isoform X2 [KO:K12373] [EC:3.2.1.52]
487883  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
488577  CTSE; cathepsin E isoform X2 [KO:K01382] [EC:3.4.23.34]
489052  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
489104  CLTB; clathrin light chain B isoform X1 [KO:K04645]
489661  GALNS; N-acetylgalactosamine-6-sulfatase precursor [KO:K01132] [EC:3.1.6.4]
489681  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
490004  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
490019  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
490965  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
492194  IDS; iduronate 2-sulfatase precursor [KO:K01136] [EC:3.1.6.13]
607186  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
607494  AP3S1; AP-3 complex subunit sigma-1 isoform X4 [KO:K12399]
607705  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
608555  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X3 [KO:K12404]
608602  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
608620  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
608843  CTSK; cathepsin K precursor [KO:K01371] [EC:3.4.22.38]
609321  [KO:K01197] [EC:3.2.1.35]
609840  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
610364  ARSB; arylsulfatase B precursor [KO:K01135] [EC:3.1.6.12]
611146  CTSA; lysosomal protective protein precursor [KO:K13289] [EC:3.4.16.5]
611211  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
611468  AP1S2; AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
611517  MCOLN1; mucolipin-1 isoform X2 [KO:K04992]
611983  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
612206  GBA; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
cfa00511  Other glycan degradation
cfa00531  Glycosaminoglycan degradation
cfa04130  SNARE interactions in vesicular transport
cfa04140  Autophagy - animal
cfa04144  Endocytosis
KO pathway
ko04142   

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