KEGG   PATHWAY: cfa04666
Entry
cfa04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Canis lupus familiaris (dog)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
cfa04666  Fc gamma R-mediated phagocytosis
cfa04666

Other DBs
GO: 0006909
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100684309  CRK; adapter molecule crk isoform X8 [KO:K04438]
100687971  [KO:K05765]
100688270  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
100855828  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100856270  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
100856339  [KO:K02649]
100856443  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
100856747  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X2 [KO:K05756]
102152609  [KO:K05765]
102153978  [KO:K05765]
102154266  [KO:K05765]
106560075  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
111097183  [KO:K06856]
119863888  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119866928  [KO:K04393]
119869994  [KO:K13536]
403462  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
403702  ACTR3; actin-related protein 3 [KO:K18584]
403936  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
474819  GSN; gelsolin isoform X1 [KO:K05768]
475024  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X2 [KO:K05753]
475245  SCIN; adseverin isoform X1 [KO:K05768]
475549  ACTR3B; actin-related protein 3B isoform X4 [KO:K18584]
475659  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X8 [KO:K12488]
475846  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
475877  AMPH; amphiphysin isoform X1 [KO:K12562]
476022  CFL1; cofilin-1 [KO:K05765]
476331  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3 [KO:K00889] [EC:2.7.1.68]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
477331  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
477886  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
478907  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
478984  [KO:K06463]
479473  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
479557  PLPP3; phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
479744  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
479745  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
479921  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
480037  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
480048  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
480580  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
481256  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
481271  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
481396  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
482044  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
483329  SPHK1; sphingosine kinase 1 isoform X4 [KO:K04718] [EC:2.7.1.91]
483870  BIN1; myc box-dependent-interacting protein 1 isoform X5 [KO:K12562]
484196  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
484401  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
484949  DNM2; dynamin-2 isoform X11 [KO:K23484]
485016  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
485054  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
485167  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
485209  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
485828  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
485874  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
486363  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
486934  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
487343  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
487377  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X5 [KO:K12488]
487512  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
487514  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
487515  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
488167  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
489261  MYO10; unconventional myosin-X isoform X7 [KO:K12559]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
489692  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
489800  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
489968  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
490255  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X18 [KO:K06478] [EC:3.1.3.48]
490649  CFL2; cofilin-2 isoform X2 [KO:K05765]
490679  ARF6; ADP-ribosylation factor 6 [KO:K07941]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490904  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
491867  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
494005  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
607700  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
607885  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
607947  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
607962  PLPP1; phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
608060  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
608125  CRKL; crk-like protein isoform X2 [KO:K04438]
608811  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
609934  PRKCE; protein kinase C epsilon type isoform X3 [KO:K18050] [EC:2.7.11.13]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
610499  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
612436  MARCKS; myristoylated alanine-rich C-kinase substrate isoform X1 [KO:K12561]
612856  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
612998  MARCKSL1; MARCKS-related protein [KO:K13536]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
cfa04020  Calcium signaling pathway
cfa04142  Lysosome
cfa04144  Endocytosis
cfa04810  Regulation of actin cytoskeleton
KO pathway
ko04666   

DBGET integrated database retrieval system