Entry Name Inflammatory mediator regulation of TRP channels - Canis lupus familiaris (dog)
Description The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive dorsal root ganglion (DRG) neuron cell bodies including their peripheral and central projections. These channels can be modulated indirectly by inflammatory mediators such as PGE2, bradykinin, ATP, NGF, and proinflammatory cytokines that are generated during tissue injury. While the noxious heat receptor TRPV1 is sensitized (that is, their excitability can be increased) by post-translational modifications upon activation of G-protein coupled receptors (GPCRs) or tyrosine kinase receptors, the receptors for inflammatory mediators, the same action appears to mainly desensitize TRPM8, the main somatic innocuous cold sensor. This aforementioned sensitization could allow the receptor to become active at body temperature, so it not only contributes toward thermal hypersensitivity but also is possibly a substrate for ongoing persistent pain.
Class Organismal Systems; Sensory systemBRITE hierarchy
Pathway map cfa04750 Inflammatory mediator regulation of TRP channels
Other DBs Organism Canis lupus familiaris (dog) [GN:
cfa ]
Gene 100856190 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
403557 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
403558 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
403589 PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261 ]
403609 PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
403797 PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259 ]
403928 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
403943 GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
445457 TRPV1; transient receptor potential cation channel subfamily V member 1 [KO:K05222 ]
450240 HTR2C; 5-hydroxytryptamine receptor 2C precursor [KO:K04157 ]
476034 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
476548 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
477085 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
477160 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
477612 ASIC1; acid-sensing ion channel 1 isoform X1 [KO:K04829 ]
478351 CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183 ]
479975 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345 ] [EC:2.7.11.11 ]
480454 MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433 ] [EC:2.7.12.2 ]
481256 PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343 ] [EC:3.1.1.4 ]
481328 IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386 ]
481746 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
482687 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
482801 ASIC3; acid-sensing ion channel 3 isoform X1 [KO:K04830 ]
485773 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
485874 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
486170 TRPM8; transient receptor potential cation channel subfamily M member 8 [KO:K04983 ]
486308 TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
486628 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959 ]
486994 TRPA1; transient receptor potential cation channel subfamily A member 1 [KO:K04984 ]
487235 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
488084 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
488126 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
488537 ASIC4; acid-sensing ion channel 4 isoform X1 [KO:K04831 ]
488940 F2RL1; proteinase-activated receptor 2 precursor [KO:K04234 ]
489050 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
489522 TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971 ]
489644 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
489692 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
491150 ASIC2; acid-sensing ion channel 2 isoform X2 [KO:K04828 ]
491218 TRPV3; transient receptor potential cation channel subfamily V member 3 [KO:K04972 ]
607269 CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183 ]
607357 ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 isoform X5 [KO:K08041 ] [EC:4.6.1.1 ]
609956 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
610255 IGF1; insulin-like growth factor I precursor [KO:K05459 ]
610764 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
612941 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04742 (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C12083 (5Z,7E,9E,14Z,17Z)-Icosapentaenoate
C20698 2-Aminoethyl diphenylborinate
Reference Authors Wang H, Woolf CJ
Title Pain TRPs.
Journal Reference Authors Levine JD, Alessandri-Haber N
Title TRP channels: targets for the relief of pain.
Journal Reference Authors Cheng JK, Ji RR
Title Intracellular signaling in primary sensory neurons and persistent pain.
Journal Reference Authors Julius D
Title TRP channels and pain.
Journal Reference Authors Patapoutian A, Peier AM, Story GM, Viswanath V
Title ThermoTRP channels and beyond: mechanisms of temperature sensation.
Journal Reference Authors Dhaka A, Viswanath V, Patapoutian A
Title Trp ion channels and temperature sensation.
Journal Reference Authors Story GM
Title The emerging role of TRP channels in mechanisms of temperature and pain sensation.
Journal Reference Authors Velazquez KT, Mohammad H, Sweitzer SM
Title Protein kinase C in pain: involvement of multiple isoforms.
Journal Reference Authors Zhang X, Huang J, McNaughton PA
Title NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
Journal Reference Authors Bessac BF, Jordt SE
Title Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
Journal Reference Authors Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
Title 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Journal Reference Authors Latorre R, Brauchi S, Madrid R, Orio P
Title A cool channel in cold transduction.
Journal Reference Authors Babes A, Ciobanu AC, Neacsu C, Babes RM
Title TRPM8, a sensor for mild cooling in mammalian sensory nerve endings.
Journal Reference Authors Loyd DR, Henry MA, Hargreaves KM
Title Serotonergic neuromodulation of peripheral nociceptors.
Journal Reference Authors Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW
Title Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Journal Reference Authors Mandadi S, Armati PJ, Roufogalis BD
Title Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling.
Journal Related KO pathway 
