KEGG   PATHWAY: dme04150
Entry
dme04150                    Pathway                                
Name
mTOR signaling pathway - Drosophila melanogaster (fruit fly)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dme04150  mTOR signaling pathway
dme04150

Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG3297  mnd; minidiscs, isoform A [KO:K13780]
Dmel_CG6070  gb; genderblind, isoform B [KO:K13780]
Dmel_CG12317  JhI-21; juvenile hormone Inducible-21, isoform C [KO:K13780]
Dmel_CG2791  CD98hc; CD98 heavy chain, isoform G [KO:K06519]
Dmel_CG3762  Vha68-2; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [KO:K02145] [EC:7.1.2.2]
Dmel_CG5075  Vha68-3; vacuolar H[+] ATPase 68kD subunit 3 [KO:K02145] [EC:7.1.2.2]
Dmel_CG12403  Vha68-1; vacuolar H[+] ATPase 68kD subunit 1, isoform B [KO:K02145] [EC:7.1.2.2]
Dmel_CG17369  Vha55; vacuolar H[+]-ATPase 55kD subunit, isoform C [KO:K02147]
Dmel_CG8048  Vha44; vacuolar H[+] ATPase 44kD subunit, isoform F [KO:K02148]
Dmel_CG8310  Vha36-3; vacuolar H[+] ATPase 36kD subunit 3, isoform C [KO:K02149]
Dmel_CG8186  Vha36-1; vacuolar H[+] ATPase 36kD subunit 1 [KO:K02149]
Dmel_CG13167  Vha36-2; vacuolar H[+] ATPase 36kD subunit 2 [KO:K02149]
Dmel_CG1088  Vha26; vacuolar H[+]-ATPase 26kD subunit, isoform C [KO:K02150]
Dmel_CG8210  Vha14-1; vacuolar H[+] ATPase 14kD subunit 1 [KO:K02151]
Dmel_CG1076  Vha14-2; vacuolar H[+] ATPase 14kD subunit 2, isoform A [KO:K02151]
Dmel_CG15719  CG15719; uncharacterized protein, isoform D [KO:K02151]
Dmel_CG6213  Vha13; vacuolar H[+] ATPase 13kD subunit, isoform B [KO:K02152]
Dmel_CG17332  VhaSFD; vacuolar H[+]-ATPase SFD subunit, isoform E [KO:K02144]
Dmel_CG14184  Lamtor1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, isoform B [KO:K20397]
Dmel_CG5189  Lamtor2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, isoform B [KO:K20398]
Dmel_CG5110  Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, isoform B [KO:K04370]
Dmel_CG14977  Lamtor4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4, isoform A [KO:K20399]
Dmel_CG14812  Lamtor5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5, isoform B [KO:K16344]
Dmel_CG8616  BHD; Birt-Hogg-Dube [KO:K09594]
Dmel_CG3764  CG3764; uncharacterized protein, isoform B [KO:K20401]
Dmel_CG11968  RagA-B; Ras-related GTP binding A/B [KO:K16185]
Dmel_CG8707  RagC-D; Ras-related GTP binding C/D [KO:K16186]
Dmel_CG7074  mio; missing oocyte [KO:K20407]
Dmel_CG8722  Nup44A; nucleoporin at 44A, isoform A [KO:K14299]
Dmel_CG7609  Wdr24; WD repeat domain 24, isoform B [KO:K20408]
Dmel_CG4705  Wdr59; WD repeat domain 59, isoform D [KO:K20409]
Dmel_CG6773  Sec13; secretory 13, isoform B [KO:K14004]
Dmel_CG12090  Iml1; increased minichromosome loss 1, isoform A [KO:K20404]
Dmel_CG9104  Nprl2; nitrogen permease regulator-like 2 [KO:K20405]
Dmel_CG8783  Nprl3; nitrogen permease regulator-like 3, isoform C [KO:K20406]
Dmel_CG9772  Skp2; S-phase kinase-associated protein 2, isoform A [KO:K03875]
Dmel_CG4320  raptor; raptor, isoform C [KO:K07204]
Dmel_CG5092  mTor; mechanistic target of rapamycin, isoform A [KO:K07203] [EC:2.7.11.1]
Dmel_CG3004  Lst8; Lst8 [KO:K08266]
Dmel_CG16908  Tti1; Telo2 interacting protein 1 [KO:K20403]
Dmel_CG5020  CLIP-190; cytoplasmic linker protein 190, isoform A [KO:K10421]
Dmel_CG8709  Lpin; lipin, isoform B [KO:K15728] [EC:3.1.3.4]
Dmel_CG10967  Atg1; Autophagy-related 1, isoform B [KO:K08269] [EC:2.7.11.1]
Dmel_CG1442  eIF4E6; eukaryotic translation initiation factor 4E6, isoform B [KO:K03259]
Dmel_CG10124  eIF4E4; eukaryotic translation initiation factor 4E4 [KO:K03259]
Dmel_CG4035  eIF4E1; eukaryotic translation initiation factor 4E1, isoform H [KO:K03259]
Dmel_CG33100  eIF4EHP; eukaryotic translation initiation factor 4E homologous protein, isoform B [KO:K03259]
Dmel_CG8023  eIF4E3; eukaryotic translation initiation factor 4E3 [KO:K03259]
Dmel_CG32859  eIF4E7; eukaryotic translation initiation factor 4E7 [KO:K03259]
Dmel_CG8277  eIF4E5; eukaryotic translation initiation factor 4E5 [KO:K03259]
Dmel_CG10539  S6k; ribosomal protein S6 kinase, isoform B [KO:K04688] [EC:2.7.11.1]
Dmel_CG10837  eIF4B; eukaryotic translation initiation factor 4B, isoform B [KO:K03258]
Dmel_CG10944  RpS6; ribosomal protein S6, isoform B [KO:K02991]
Dmel_CG40293  Stlk; Ste20-like kinase, isoform A [KO:K08271]
Dmel_CG9374  Lkb1; Lkb1 kinase, isoform J [KO:K07298] [EC:2.7.11.1]
Dmel_CG4083  Mo25; Mo25, isoform B [KO:K08272]
Dmel_CG3051  AMPKalpha; AMP-activated protein kinase alpha subunit, isoform A [KO:K07198] [EC:2.7.11.31]
Dmel_CG6147  Tsc1; Tsc1 [KO:K07206]
Dmel_CG6975  gig; gigas, isoform B [KO:K07207]
Dmel_CG6182  TBC1d7; TBC1 domain family member 7 [KO:K20396]
Dmel_CG1081  Rheb; Ras homolog enriched in brain, isoform A [KO:K07208]
Dmel_CG4889  wg; wingless [KO:K03209]
Dmel_CG6407  Wnt5; Wnt oncogene analog 5, isoform B [KO:K00444]
Dmel_CG4969  Wnt6; Wnt oncogene analog 6, isoform C [KO:K00445]
Dmel_CG8458  wntD; wnt inhibitor of dorsal [KO:K00714]
Dmel_CG4971  Wnt10; Wnt oncogene analog 10 [KO:K01357]
Dmel_CG17697  fz; frizzled, isoform A [KO:K02432]
Dmel_CG4626  fz4; frizzled 4, isoform A [KO:K02354]
Dmel_CG9739  fz2; frizzled 2, isoform C [KO:K02375]
Dmel_CG16785  fz3; frizzled 3, isoform C [KO:K04690]
Dmel_CG5912  arr; arrow [KO:K03068]
Dmel_CG18361  dsh; dishevelled [KO:K02353]
Dmel_CG2621  sgg; shaggy, isoform B [KO:K03083] [EC:2.7.11.26]
Dmel_CG31003  gskt; gasket [KO:K03083] [EC:2.7.11.26]
Dmel_CG4201  IKKbeta; I-kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
Dmel_CG33273  Ilp5; Insulin-like peptide 5 [KO:K04526]
Dmel_CG8167  Ilp2; Insulin-like peptide 2 [KO:K04526]
Dmel_CG14173  Ilp1; Insulin-like peptide 1 [KO:K04526]
Dmel_CG14167  Ilp3; Insulin-like peptide 3 [KO:K04526]
Dmel_CG6736  Ilp4; Insulin-like peptide 4 [KO:K04526]
Dmel_CG14049  Ilp6; Insulin-like peptide 6, isoform B [KO:K05459]
Dmel_CG18402  InR; Insulin-like receptor, isoform B [KO:K05087] [EC:2.7.10.1]
Dmel_CG6033  drk; downstream of receptor kinase, isoform A [KO:K04364]
Dmel_CG7793  Sos; Son of sevenless [KO:K03099]
Dmel_CG9375  Ras85D; Ras oncogene at 85D [KO:K07827]
Dmel_CG2845  Raf; Raf oncogene, isoform E [KO:K04365] [EC:2.7.11.1]
Dmel_CG15793  Dsor1; downstream of raf1, isoform A [KO:K04368] [EC:2.7.12.2]
Dmel_CG12559  rl; rolled, isoform C [KO:K04371] [EC:2.7.11.24]
Dmel_CG17596  S6kII; ribosomal protein S6 kinase II, isoform B [KO:K04373] [EC:2.7.11.1]
Dmel_CG5686  chico; chico, isoform B [KO:K16172]
Dmel_CG2699  Pi3K21B; Pi3K21B, isoform C [KO:K02649]
Dmel_CG4141  Pi3K92E; phosphatidylinositol 3-kinase 92E, isoform C [KO:K00922] [EC:2.7.1.153]
Dmel_CG5671  Pten; phosphatase and tensin homolog, isoform G [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Dmel_CG1210  Pdk1; Phosphoinositide-dependent kinase 1, isoform J [KO:K06276] [EC:2.7.11.1]
Dmel_CG4006  Akt; Akt kinase, isoform C [KO:K04456] [EC:2.7.11.1]
Dmel_CG10105  Sin1; SAPK-interacting protein 1 [KO:K20410]
Dmel_CG8002  rictor; rapamycin-insensitive companion of Tor, isoform B [KO:K08267]
Dmel_CG8416  Rho1; Rho1, isoform A [KO:K04513]
Dmel_CG6518  inaC; inactivation no afterpotential C [KO:K02677] [EC:2.7.11.13]
Dmel_CG6622  Pkc53E; protein C kinase 53E, isoform B [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dme00561  Glycerolipid metabolism
dme04140  Autophagy - animal
KO pathway
ko04150   
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