KEGG   PATHWAY: dre00280
Entry
dre00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Danio rerio (zebrafish)
Class
Metabolism; Amino acid metabolism
Pathway map
dre00280  Valine, leucine and isoleucine degradation
dre00280

Module
dre_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:dre00280]
dre_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:dre00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
337412  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
436949  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 [KO:K00826] [EC:2.6.1.42]
337166  si:dkey-40g16.6; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
554124  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
569980  bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
541388  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
399479  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
445288  acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
406283  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
368775  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
100037342  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
110437777  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
394130  acad8; isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
793834  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
553401  hadhaa; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100000859  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
368912  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
445121  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
450078  hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
431754  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
406325  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
336606  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
437019  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
405861  pccb; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
553804  mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
569581  mmut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
798364  hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [KO:K05605] [EC:3.1.2.4]
394135  hibadhb; 3-hydroxyisobutyrate dehydrogenase b [KO:K00020] [EC:1.1.1.31]
445252  hibadha; 3-hydroxyisobutyrate dehydrogenase a [KO:K00020] [EC:1.1.1.31]
436647  aldh6a1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
323653  aldh3a2a; aldehyde dehydrogenase family 3 member A2a [KO:K00128] [EC:1.2.1.3]
393462  aldh2.1; aldehyde dehydrogenase 2 family member, tandem duplicate 1 [KO:K00128] [EC:1.2.1.3]
368239  aldh2.2; aldehyde dehydrogenase 2 family member, tandem duplicate 2 [KO:K00128] [EC:1.2.1.3]
100000026  aldh3a1; fatty aldehyde dehydrogenase isoform X2 [KO:K00128] [EC:1.2.1.3]
492710  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
447920  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
100536795  wu:fb14d09; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
334197  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100005587  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
399481  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100006238  aldh9a1a.2; aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
570457  aox6; aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
64265  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
562292  acsf3; acyl-CoA synthetase family member 3, mitochondrial [KO:K18660] [EC:6.2.1.76 6.2.1.-]
378968  abat; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
619269  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
777632  mccc1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
405863  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
100004018  si:ch211-198n5.11; methylcrotonoyl-coenzyme A carboxylase 2 [KO:K01969] [EC:6.4.1.4]
445182  auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
394190  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
571388  hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
442923  oxct1a; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
560273  oxct1b; 3-oxoacid CoA transferase 1b [KO:K01027] [EC:2.8.3.5]
797311  LOW QUALITY PROTEIN: succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial-like isoform X1 [KO:K01027] [EC:2.8.3.5]
393984  aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
30643  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
445290  acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
394060  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
dre00020  Citrate cycle (TCA cycle)
dre00240  Pyrimidine metabolism
dre00290  Valine, leucine and isoleucine biosynthesis
dre00640  Propanoate metabolism
dre00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   
LinkDB

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