KEGG   PATHWAY: dre04144
Entry
dre04144                    Pathway                                
Name
Endocytosis - Danio rerio (zebrafish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dre04144  Endocytosis
dre04144

Other DBs
GO: 0006897
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
336063  arf6a; ADP-ribosylation factor 6a [KO:K07941]
100003206  arf6b; ADP-ribosylation factor 6b [KO:K07941]
449831  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
553629  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
492549  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
447840  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
798876  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
100005033  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b [KO:K00889] [EC:2.7.1.68]
100149843  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X2 [KO:K13712] [EC:2.7.1.68]
565743  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
799278  si:ch211-168k14.2; phospholipase D1 isoform X4 [KO:K01115] [EC:3.1.4.4]
572492  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
556641  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
100307098  dnm1a; dynamin-1a [KO:K01528] [EC:3.6.5.5]
100333543  dnm1b; dynamin-1 [KO:K01528] [EC:3.6.5.5]
559334  dnm2a; dynamin-3 [KO:K23484] [EC:3.6.5.5]
406525  dnm2b; dynamin-2 [KO:K23484] [EC:3.6.5.5]
406318  clta; clathrin light chain A [KO:K04644]
100329879  cltb; clathrin light chain B isoform X1 [KO:K04645]
323579  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
503600  cltcb; clathrin, heavy chain b (Hc) [KO:K04646]
100330183  cltcl1; clathrin heavy chain 1 [KO:K04646]
558153  ap2a1; AP-2 complex subunit alpha-2 isoform X2 [KO:K11824]
334632  ap2b1; AP-2 complex subunit beta [KO:K11825]
321051  ap2m1a; AP-2 complex subunit mu-A isoform 2 [KO:K11826]
394001  ap2m1b; AP-2 complex subunit mu-B [KO:K11826]
100148085  ap2s1; AP-2 complex subunit sigma [KO:K11827]
567055  ehd2a; EH domain-containing protein 2-like [KO:K12469]
337401  ehd2b; EH domain-containing protein 2b [KO:K12469]
560578  tgfbr1a; TGF-beta receptor type-1a precursor [KO:K04674] [EC:2.7.11.30]
792928  tgfbr1b; TGF-beta receptor type-1b precursor [KO:K04674] [EC:2.7.11.30]
30739  tgfbr2b; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
560446  si:dkey-101k6.5; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100005449  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X2 [KO:K04679]
794689  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
101882992  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
30639  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
326283  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
58092  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
494477  tfr1a; transferrin receptor 1a [KO:K06503]
494478  tfr1b; transferrin receptor 1b [KO:K06503]
378478  egfra; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
571431  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
386856  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
352940  fgfr2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1]
58129  fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
100000160  fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
245701  igf1ra; insulin-like growth factor 1a receptor precursor [KO:K05087] [EC:2.7.10.1]
245702  igf1rb; insulin-like growth factor 1b receptor precursor [KO:K05087] [EC:2.7.10.1]
492364  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
556277  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
565383  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
793623  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
571626  sh3gl3a; endophilin-A3a [KO:K11247]
394091  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 [KO:K11247]
378838  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
393150  sh3gl3b; endophilin-A3b [KO:K11247]
100005753  sh3gl1a; SH3-domain GRB2-like 1a isoform 1 [KO:K11247]
794400  sh3gl2b; SH3 domain containing GRB2 like 2b, endophilin A1 [KO:K11247]
792229  sh3glb1a; endophilin-B1a [KO:K11248]
334911  sh3glb1b; endophilin-B1b [KO:K11248]
402885  sh3glb2a; endophilin-B2a [KO:K21269]
394094  sh3glb2b; endophilin-B2b [KO:K21269]
393804  amph; amphiphysin [KO:K12562]
447863  bin1b; myc box-dependent-interacting protein 1b isoform 2 [KO:K12562]
563561  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
406671  epn1a; epsin-1 [KO:K12471]
571453  epn3b; epsin-3 [KO:K12471]
792915  epn1b; uncharacterized protein LOC792915 [KO:K12471]
794862  epn3a; epsin-3 isoform X2 [KO:K12471]
560542  epn2; epsin-2 isoform X2 [KO:K12471]
795505  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
568170  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
100329948  eps15l1b; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
100005765  sparta; spartin a [KO:K19366]
559634  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X16 [KO:K13305] [EC:2.3.2.26]
30637  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform 1 [KO:K06643] [EC:2.3.2.27]
554561  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
406837  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
100331274  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
100330031  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
563633  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
321695  smurf1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
103909792  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
387529  ldlra; low density lipoprotein receptor a precursor [KO:K12473]
368278  ldlrap1a; low density lipoprotein receptor adapter protein 1a [KO:K12474]
791153  ldlrap1b; low density lipoprotein receptor adapter protein 1b [KO:K12474]
572485  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
404040  dab2; disabled homolog 2 isoform a [KO:K12475]
368323  si:ch211-204c21.1; disabled homolog 2 isoform X1 [KO:K12475]
100005081  si:ch211-207g17.3; C-C chemokine receptor type 5-like [KO:K04180]
100004988  si:ch211-207g17.2; C-C chemokine receptor type 5-like [KO:K04180]
100004625  ccr11.1; C-C chemokine receptor type 2 [KO:K04180]
796724  cxcr2; C-X-C chemokine receptor type 1-like [KO:K05050]
797181  C-X-C chemokine receptor type 1-like [KO:K05050]
140747  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
114447  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
550406  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
564152  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
373871  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
566120  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
569403  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
560761  grk4; G protein-coupled receptor kinase 4 isoform 2 [KO:K08291] [EC:2.7.11.16]
561288  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
567452  grk5l; G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
560806  grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
394099  arrb2b; arrestin, beta 2b [KO:K04439]
321378  arrb2a; arrestin, beta 2a [KO:K04439]
553266  arrb1; beta-arrestin-1 [KO:K04439]
394034  waslb; WASP like actin nucleation promoting factor b [KO:K23612]
100009637  wasla; WASP like actin nucleation promoting factor a [KO:K23612]
406820  actr2a; actin-related protein 2-A [KO:K17260]
493612  zgc:101810; uncharacterized protein LOC493612 [KO:K17260]
554861  actr2b; actin-related protein 2-B [KO:K17260]
100038776  actr3b; actin-related protein 3B [KO:K18584]
406250  actr3; actin-related protein 3 [KO:K18584]
335474  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
394243  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
415190  zgc:86896; uncharacterized protein LOC415190 [KO:K05757]
327068  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
415204  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114456  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
445305  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
336504  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
393550  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
399482  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
556104  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
563976  wipf2a; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
100151491  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
415255  wipf2b; WAS/WASL-interacting protein family member 2b [KO:K19475]
368364  sb:cb649; WAS/WASL-interacting protein family member 3 [KO:K19475]
100005341  wipf1a; WAS/WASL-interacting protein family member 1a [KO:K19475]
30671  hsp70.3; heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
393586  hsc70; uncharacterized protein LOC393586 [KO:K03283]
573376  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
560210  hsp70l; heat shock cognate 70-kd protein, like [KO:K03283]
798846  hspa1b; Heat shock 70 kDa protein-like [KO:K03283]
100535101  hsp70.2; heat shock cognate 70-kd protein, tandem duplicate 2 [KO:K03283]
100126123  hsp70.1; heat shock cognate 70-kd protein, tandem duplicate 1 [KO:K03283]
562935  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
796345  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X3 [KO:K09526]
565752  si:dkey-23p11.2; WASH complex subunit 4 [KO:K18465]
393152  washc5; WASH complex subunit 5 [KO:K18464]
567272  fam21c; WASH complex subunit 2 isoform X2 [KO:K18462]
555174  wash1; WASH complex subunit 1 [KO:K18461]
393142  washc3; WASH complex subunit 3 [KO:K18463]
327029  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
474327  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
335083  capzb; F-actin-capping protein subunit beta [KO:K10365]
573437  vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
393881  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
406684  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
436688  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
561697  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
394098  snx12; sorting nexin-12 isoform 3 [KO:K17918]
563511  snx3; sorting nexin-3 [KO:K17918]
565434  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
641572  stambpb; STAM binding protein b [KO:K11866] [EC:3.4.19.12]
797422  stambpa; STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
393902  rab7a; ras-related protein Rab-7a [KO:K07897]
431725  rab7b; ras-related protein Rab-7b [KO:K07897]
449549  zgc:100918; Ras-related protein rab7-like [KO:K07897]
494576  si:dkey-13a21.4; uncharacterized protein LOC494576 [KO:K07897]
334175  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
386967  stam; signal transducing adapter molecule 1 [KO:K04705]
492497  stam2; signal transducing adapter molecule 2 [KO:K04705]
415179  tsg101a; tumor susceptibility 101a [KO:K12183]
100333057  tsg101b; tumor susceptibility gene 101 protein-like [KO:K12183]
100004330  mvb12bb; multivesicular body subunit 12Bb [KO:K12186]
393456  mvb12a; multivesicular body subunit 12A [KO:K12186]
767667  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
393562  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
559483  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
566797  vps37bb; VPS37B subunit of ESCRT-I b [KO:K12185]
777738  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
336368  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
101884856  si:ch211-284f22.3; vacuolar protein sorting-associated protein 37D [KO:K12185]
492771  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
335810  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
407684  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
100147988  chmp6a; charged multivesicular body protein 6-like isoform X1 [KO:K12195]
445397  chmp6b; charged multivesicular body protein 6 [KO:K12195]
393164  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
406766  chmp4bb; charged multivesicular body protein 4c [KO:K24782]
550542  chmp4c; charged multivesicular body protein 4c [KO:K24782]
406621  chmp3; charged multivesicular body protein 3 [KO:K12193]
798901  chmp2a; charged multivesicular body protein 2a [KO:K12191]
569532  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
405840  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
393754  chmp7; charged multivesicular body protein 7 [KO:K15053]
393880  vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
767670  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
406414  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
336426  chmp1b; charged multivesicular body protein 1b [KO:K12197]
393535  chmp1a; charged multivesicular body protein 1a [KO:K12197]
558613  chmp5a; charged multivesicular body protein 5 [KO:K12198]
393351  chmp5b; charged multivesicular body protein 5 [KO:K12198]
321460  ist1; IST1 homolog isoform 2 [KO:K19476]
406669  pdcd6ip; programmed cell death 6-interacting protein [KO:K12200]
406704  spg21; maspardin [KO:K19367]
557061  igf2r; cation-independent mannose-6-phosphate receptor precursor [KO:K06564]
337386  snx1a; sorting nexin-1a [KO:K17917]
568737  snx2; sorting nexin-2 [KO:K17917]
619253  snx1b; uncharacterized protein LOC619253 [KO:K17917]
406797  snx5; sorting nexin-5 [KO:K17920]
567182  snx6; sorting nexin-6 [KO:K17920]
557582  si:dkey-28n18.9; sorting nexin-5-like [KO:K17920]
325084  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
553656  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
550286  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
793920  il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069]
796604  il2rga; interleukin 2 receptor, gamma a precursor [KO:K05070]
100144554  il2rgb; interleukin 2 receptor, gamma b precursor [KO:K05070]
406411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
406659  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
436718  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
751630  zgc:153713; RhoA_like domain-containing protein [KO:K04513]
100006041  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
64885  mhc1uea; major histocompatibility complex class I UEA precursor [KO:K06751]
393557  mhc1uxa2; major histocompatibility complex class I UXA2 precursor [KO:K06751]
791453  mhc1zba; major histocompatibility complex class I ZBA precursor [KO:K06751]
767703  mhc1uha; major histocompatibility complex class I UHA precursor [KO:K06751]
393377  mhc1uja; major histocompatibility complex class I UJA precursor [KO:K06751]
100073336  folr; folate receptor precursor [KO:K13649]
553764  rtbdn; retbindin precursor [KO:K13649]
323695  cav1; caveolin-1 isoform b [KO:K06278]
415240  cav2; caveolin-2 [KO:K12958]
791212  cav4b; uncharacterized protein LOC791212 [KO:K12958]
100136849  cav4a; uncharacterized protein LOC100136849 [KO:K12958]
449679  cav3; caveolin-3 [KO:K12959]
562949  ehd3; EH domain-containing protein 3 [KO:K12476]
569546  ehd4; EH domain-containing protein 4 [KO:K12477]
492695  eea1; early endosome antigen 1 [KO:K12478]
337737  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
393945  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
405821  rab5b; ras-related protein Rab-5B [KO:K07888]
386807  rab5c; ras-related protein Rab-5C [KO:K07889]
568064  rabep1; rab GTPase-binding effector protein 1 isoform 2 [KO:K12480]
569240  rbsn; rabenosyn-5 [KO:K12481]
403031  rab4a; ras-related protein Rab-4A [KO:K07879]
100330077  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
569096  rufy2; RUN and FYVE domain-containing protein 2 isoform 2 [KO:K12482]
405810  ehd1a; EH domain-containing protein 1a [KO:K12483]
447839  ehd1b; EH domain-containing protein 1b [KO:K12483]
561653  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
323203  snx4; sorting nexin-4 [KO:K17919]
100001531  rab22a; ras-related protein Rab-22A [KO:K07891]
568800  rab31; ras-related protein Rab-31 isoform X2 [KO:K07891]
436839  rab10; ras-related protein Rab-10 [KO:K07903]
571897  rab8a; ras-related protein Rab-8A [KO:K07901]
445154  rab35b; ras-related protein Rab-35b [KO:K07876]
100003902  si:dkey-16l2.16; ras-related protein Rab-35-like [KO:K07876]
796454  rab35a; ras-related protein Rab-35 [KO:K07876]
386994  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
492487  rab11a; ras-related protein Rab-11A [KO:K07904]
406798  rab11ba; RAB11B, member RAS oncogene family, a [KO:K07905]
436828  rab11bb; RAB11B, member RAS oncogene family, b [KO:K07905]
570939  uncharacterized protein LOC570939 isoform X1 [KO:K12484]
100334729  rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
553374  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
562719  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
402861  rab11fip1b; calponin homology domain-containing protein DDB_G0272472 isoform X1 [KO:K12484]
561659  zfyve27; protrudin [KO:K19368]
563459  kif5ba; kinesin-1 heavy chain isoform X1 [KO:K10396]
799274  kif5ab; kinesin heavy chain isoform X2 [KO:K10396]
565563  kif5c; kinesin heavy chain isoform 5C [KO:K10396]
334108  kif5bb; kinesin-1 heavy chain [KO:K10396]
566086  kif5aa; kinesin family member 5Aa [KO:K10396]
436806  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
100151129  rab11fip4b; rab11 family-interacting protein 4B [KO:K12485]
573631  rab11fip3; rab11 family-interacting protein 3 [KO:K12485]
403050  pard3ab; par-3 family cell polarity regulator alpha, b isoform 1 [KO:K04237]
101882925  pard3aa; partitioning defective 3 homolog [KO:K04237]
80959  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
100124652  pard6b; partitioning defective 6 homolog beta [KO:K06093]
792828  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
100170824  pard6ga; par-6 family cell polarity regulator gamma a [KO:K06093]
555737  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
117507  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
336839  cdc42; cell division control protein 42 homolog isoform 2 [KO:K04393]
556226  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
793158  cdc42l; cell division cycle 42, like [KO:K04393]
777731  smap1; stromal membrane-associated protein 1 [KO:K12486]
556132  smap2; stromal membrane-associated protein 2 [KO:K12486]
568935  git1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
793882  git2a; ARF GTPase-activating protein GIT2a [KO:K12487]
567190  git2b; ARF GTPase-activating protein GIT2b isoform 1 [KO:K12487]
560581  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
561879  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
565859  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7 [KO:K12488]
570669  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a [KO:K12488]
100170829  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a [KO:K12488]
664764  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform 1 [KO:K12488]
100009646  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b [KO:K12489]
561771  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
100004931  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
564814  si:ch211-168b3.1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
322991  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
100332526  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
100005008  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
571767  si:ch211-135f11.1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3 [KO:K18439]
559690  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
558931  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12490]
100148154  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6 [KO:K12491]
324332  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
565109  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
100149572  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
641490  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
402889  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
559329  psd3l; PH and SEC7 domain-containing protein 3 [KO:K12494]
100151196  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
570918  si:ch211-150i13.1; PH and SEC7 domain-containing protein 1 isoform X3 [KO:K12494]
557199  psd2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
103911953  uncharacterized protein LOC103911953 [KO:K12494]
560461  IQ motif and SEC7 domain-containing protein 2 isoform X5 [KO:K12495]
100148736  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X3 [KO:K12495]
555340  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495]
797187  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X3 [KO:K12495]
797355  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495]
100334106  iqsec1a; IQ motif and Sec7 domain ArfGEF 1a isoform 1 [KO:K12495]
100002190  cyth3a; cytohesin-3 [KO:K18441]
100141338  cyth4b; cytohesin 4b [KO:K18441]
100537448  cyth3b; cytohesin-3 isoform X2 [KO:K18441]
321938  cyth1a; cytohesin-1a [KO:K18441]
325586  cyth1b; cytohesin-1b [KO:K18441]
566849  cyth4a; cytohesin-3 [KO:K18441]
569358  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
100329953  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
100334572  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
566350  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
327026  arf2b; ADP-ribosylation factor 2b [KO:K07937]
399477  arf2a; ADP-ribosylation factor 2a [KO:K07937]
114428  arf1; ADP-ribosylation factor 1 [KO:K07937]
368822  arf3b; ADP-ribosylation factor 3b [KO:K07938]
445047  arf3a; ADP-ribosylation factor 3a [KO:K07938]
334219  zgc:77650; uncharacterized protein LOC334219 [KO:K07939]
100333040  si:ch1073-165f9.2; ADP-ribosylation factor 1-like [KO:K07939]
378724  arf5; ADP-ribosylation factor 5 [KO:K07939]
550265  zgc:110286; uncharacterized protein LOC550265 [KO:K07939]
445196  arf4a; uncharacterized protein LOC445196 [KO:K07939]
550402  arf4b; ADP-ribosylation factor 4b [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dre04060  Cytokine-cytokine receptor interaction
dre04070  Phosphatidylinositol signaling system
dre04130  SNARE interactions in vesicular transport
dre04142  Lysosome
dre04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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