KEGG   PATHWAY: dre04270
Entry
dre04270                    Pathway                                
Name
Vascular smooth muscle contraction - Danio rerio (zebrafish)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
dre04270  Vascular smooth muscle contraction
dre04270

Other DBs
GO: 0014829
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
798498  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
557259  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
492486  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
100149100  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
568614  adra1d; alpha-1D adrenergic receptor [KO:K04137]
322485  agt; angiotensinogen precursor [KO:K09821]
794575  agtr1a; type-1 angiotensin II receptor [KO:K04166]
100333455  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
58032  edn1; endothelin-1 precursor [KO:K16366]
569550  edn2; endothelin-2 precursor [KO:K16367]
567978  endothelin-2-like [KO:K16367]
103909337  si:ch211-202p1.5; uncharacterized protein LOC103909337 precursor [KO:K16367]
100148183  edn3b; endothelin-3b precursor [KO:K05227]
101884385  edn3; endothelin-3 [KO:K05227]
114550  ednraa; endothelin receptor type Aa precursor [KO:K04197]
405866  ednrab; endothelin receptor type Ab precursor [KO:K04197]
352922  avp; vasopressin-neurophysin 2-copeptin precursor [KO:K05242]
555939  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
571591  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
570108  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
563953  gna11a; guanine nucleotide-binding protein subunit alpha-11a [KO:K04634]
493613  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
402802  pla2g12a; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
571738  pla2g1b; phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
436622  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
406739  pla2g12b; group XIIB secretory phospholipase A2-like protein precursor [KO:K01047] [EC:3.1.1.4]
641423  pla2g3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
100149324  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
492789  zgc:101699; uncharacterized protein LOC492789 [KO:K16342] [EC:3.1.1.4]
30554  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
565386  pla2g4f.2; cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
100148818  si:ch73-55i23.1; uncharacterized protein LOC100148818 [KO:K16342] [EC:3.1.1.4]
798864  pla2g4f.1; cytosolic phospholipase A2 zeta-like isoform X2 [KO:K16342] [EC:3.1.1.4]
559087  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100148581  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
406370  pla2g6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
798583  kcnma1b; calcium-activated potassium channel subunit alpha-1 [KO:K04936]
568554  kcnma1a; calcium-activated potassium channel subunit alpha-1a [KO:K04936]
796753  si:ch211-247n2.1; calcium-activated potassium channel subunit beta-2-like isoform X2 [KO:K04938]
541398  kcnmb2a; calcium-activated potassium channel subunit beta-2 [KO:K04938]
101885585  si:ch211-38m6.7; calcium-activated potassium channel subunit beta-3-like isoform X3 [KO:K04939]
170581  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
403310  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
403311  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
559964  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
793708  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
405791  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
570683  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
321808  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
192322  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
368217  calm1b; calmodulin-1b [KO:K02183]
406660  calm1a; calmodulin-1a [KO:K02183]
336121  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
327379  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
560151  calml4a; calmodulin-like protein 4a [KO:K02183]
100321746  calml4b; calmodulin-like protein 4 [KO:K02183]
561635  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
558685  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
492576  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
569510  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
449707  mylk4b; myosin light chain kinase family member 4 isoform X4 [KO:K00907] [EC:2.7.11.18]
566845  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X2 [KO:K00907] [EC:2.7.11.18]
100003770  mylk5; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
798632  myl6; myosin light polypeptide 6 [KO:K12751]
337226  zgc:153867; uncharacterized protein LOC337226 [KO:K12751]
406493  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
450006  myl9a; uncharacterized protein LOC450006 [KO:K12755]
554168  myh11a; myosin-11a [KO:K10352]
555454  myh10; myosin-10 isoform X5 [KO:K10352]
561431  myh9b; myosin-9 isoform X1 [KO:K10352]
333938  myh9a; myosin-9a [KO:K10352]
100001532  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100537538  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
569376  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100149080  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
407700  plcb4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100149388  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
567611  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
562585  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
794666  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
100333967  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100003514  prkcg; protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
334571  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
100150844  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
100332055  prkceb; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100005075  prkcea; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100144561  prkcha; protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
556591  prkchb; protein kinase C, eta, b [KO:K18051] [EC:2.7.11.13]
555521  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
403063  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
403065  braf; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
30716  raf1a; Raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
557109  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
406728  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
563181  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
100002225  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
360144  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399480  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
322909  cald1a; caldesmon 1a [KO:K12327]
563892  cald1b; caldesmon 1b [KO:K12327]
100536902  lsp1; non-muscle caldesmon-like [KO:K12327]
322509  acta2; actin, aortic smooth muscle [KO:K12313]
393783  ppp1r14ab; protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [KO:K12328]
550561  ppp1r14aa; protein phosphatase 1, regulatory (inhibitor) subunit 14Aa [KO:K12328]
327301  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
407980  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
334597  ppp1cbl; protein phosphatase 1, catalytic subunit, beta isoform, like [KO:K06269] [EC:3.1.3.16]
100003223  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
571753  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
445393  ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
571837  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
101885790  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
570218  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
503589  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
326825  gna13a; guanine nucleotide-binding protein subunit alpha-13a [KO:K04639]
336333  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
571031  arhgef12b; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
562455  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
557983  arhgef1b; rho guanine nucleotide exchange factor 1b [KO:K12330]
565268  arhgef11; rho guanine nucleotide exchange factor 11 [KO:K12331]
406411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
406659  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
436718  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
751630  zgc:153713; RhoA_like domain-containing protein [KO:K04513]
100006041  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
100329779  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
317747  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
321070  rock2b; rho-associated protein kinase 2b [KO:K17388] [EC:2.7.11.1]
561701  adora2aa; adenosine A2a receptor a [KO:K04266]
566118  adora2ab; adenosine A2a receptor b [KO:K04266]
560100  adora2b; adenosine receptor A2b [KO:K04267]
561406  ptgir; prostacyclin receptor [KO:K04263]
436744  calca; calcitonin/calcitonin-related polypeptide, alpha precursor [KO:K12332]
556502  adma; adrenomedullin a precursor [KO:K12333]
403114  adm2a; protein ADM2a precursor [KO:K25343]
100322075  adm2b; ADM2 [KO:K25343]
445508  calcrla; calcitonin gene-related peptide type 1 receptor precursor [KO:K04577]
567131  calcrlb; calcitonin gene-related peptide type 1 receptor [KO:K04577]
100537117  calcrl2; calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
436966  ramp1; receptor activity-modifying protein 1 precursor [KO:K08447]
566313  ramp2; receptor activity-modifying protein 2 precursor [KO:K08448]
557353  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
569499  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
557026  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
563724  adcy2a; adenylate cyclase type 2 isoform X3 [KO:K08042] [EC:4.6.1.1]
557902  adcy2b; adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
571825  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
562619  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
570652  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
560807  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
568726  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100148976  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
560719  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
560410  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100333702  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101884360  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
393998  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
445076  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
563147  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
564064  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
321442  nppa; natriuretic peptides A precursor [KO:K12334]
560653  npr1a; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
555911  npr1b; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
570244  nppc; C-type natriuretic peptide precursor [KO:K12336]
567953  nppal; natriuretic peptide A-like precursor [KO:K12336]
100148055  si:ch73-265d7.2; C-type natriuretic peptide 2-like [KO:K12336]
100331745  npr2; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
394005  prkg1a; cGMP-dependent protein kinase 1a [KO:K07376] [EC:2.7.11.12]
566430  prkg1b; cGMP-dependent protein kinase 1 isoform X2 [KO:K07376] [EC:2.7.11.12]
100331961  mrvi1; protein MRVI1 isoform X1 [KO:K12337]
550420  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
100330875  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
557191  gucy1b2; guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100150304  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
dre00590  Arachidonic acid metabolism
dre04020  Calcium signaling pathway
KO pathway
ko04270   
LinkDB

DBGET integrated database retrieval system