KEGG   PATHWAY: dre04510
Entry
dre04510                    Pathway                                
Name
Focal adhesion - Danio rerio (zebrafish)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
dre04510  Focal adhesion
dre04510

Other DBs
GO: 0005925
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
325675  col1a1b; collagen, type I, alpha 1b precursor [KO:K06236]
336471  col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
337158  col1a1a; collagen, type I, alpha 1a precursor [KO:K06236]
562496  col2a1a; collagen, type II, alpha 1a precursor [KO:K19719]
503730  col2a1b; collagen, type II, alpha 1b precursor [KO:K19719]
554268  col4a6; collagen alpha-6(IV) chain isoform X5 [KO:K06237]
553355  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
554269  col4a1; collagen alpha-1(IV) chain [KO:K06237]
323561  col4a5; collagen alpha-5(IV) chain precursor [KO:K06237]
553354  col4a3; collagen alpha-5(IV) chain [KO:K06237]
554270  col4a4; collagen alpha-4(IV) chain [KO:K06237]
567771  col6a2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
564005  col6a4a; collagen alpha-6(VI) chain [KO:K06238]
569755  col6a1; collagen alpha-1(VI) chain [KO:K06238]
556874  col6a3; uncharacterized protein col6a3 isoform X1 [KO:K06238]
100535278  collagen alpha-6(VI) chain [KO:K06238]
567110  col9a3; collagen alpha-3(IX) chain precursor [KO:K08131]
321212  col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
406548  col9a1b; collagen, type IX, alpha 1b precursor [KO:K08131]
100170785  col9a1a; collagen, type IX, alpha 1a precursor [KO:K08131]
100537277  collagen alpha-2(IX) chain-like isoform X1 [KO:K08131]
569971  lama1; laminin subunit alpha-1 precursor [KO:K05637]
100049705  lama2; laminin subunit alpha-2 precursor [KO:K05637]
567640  si:ch211-241e1.3; laminin subunit alpha-3 [KO:K06240]
321243  lama5; laminin subunit alpha-5 precursor [KO:K06240]
566796  lama4; laminin subunit alpha-4 precursor [KO:K06241]
286830  lamb1a; laminin subunit beta-1a precursor [KO:K05636]
556605  lamb1b; laminin subunit beta-1b precursor [KO:K05636]
337767  lamb2; laminin subunit beta-2 precursor [KO:K06243]
553337  lamb2l; laminin subunit beta-1 isoform X1 [KO:K06243]
101885031  laminin subunit beta-3-like [KO:K06244]
572057  si:ch1073-15f12.3; laminin subunit beta-3 [KO:K06244]
286831  lamb4; laminin subunit beta-4 precursor [KO:K06245]
286832  lamc1; laminin subunit gamma-1 precursor [KO:K05635]
567928  lamc2; laminin subunit gamma-2 [KO:K06246]
558958  lamc3; laminin subunit gamma-3 [KO:K06247]
394038  chad; chondroadherin precursor [KO:K06248]
260303  reln; reelin precursor [KO:K06249] [EC:3.4.21.-]
561901  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
100332237  thbs1a; thrombospondin-1 [KO:K16857]
252849  thbs3a; thrombospondin-3a precursor [KO:K04659]
252850  thbs4b; thrombospondin-4-B precursor [KO:K04659]
100535241  thbs2a; thrombospondin-2 [KO:K04659]
100318854  comp; cartilage oligomeric matrix protein isoform 1 precursor [KO:K04659]
563429  thbs4a; thrombospondin-4a precursor [KO:K04659]
566325  thbs2b; thrombospondin-2 [KO:K04659]
571317  thbs3b; thrombospondin-3b precursor [KO:K04659]
100005469  fn1a; fibronectin 1a precursor [KO:K05717]
553699  vtna; vitronectin a precursor [KO:K06251]
403026  vtnb; vitronectin b precursor [KO:K06251]
369191  tnr; tenascin-R precursor [KO:K06252]
30234  tnn; tenascin-N precursor [KO:K06252]
30037  tncb; tenascin isoform 2 precursor [KO:K06252]
100149028  zmp:0000000846; tenascin-like isoform X5 [KO:K06252]
570643  vwf; von Willebrand factor precursor [KO:K03900]
570868  itga1; integrin alpha-1 isoform X1 [KO:K06480]
100536533  itga2.2; integrin alpha-2-like isoform X1 [KO:K06481]
445380  itga2b; integrin alpha-IIb [KO:K06476]
407685  itga3a; integrin alpha-3 isoform X2 [KO:K06482]
100331874  itga3b; integrin alpha-3b precursor [KO:K06482]
100331333  itga4; integrin alpha-4 isoform X1 [KO:K06483]
386787  itga5; integrin alpha-5 precursor [KO:K06484]
541320  itga6b; integrin alpha-6b precursor [KO:K06485]
503893  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
555254  itga6l; integrin alpha-6 isoform X2 [KO:K06485]
100006255  itga7; integrin alpha-7 [KO:K06583]
100141346  itga8; integrin alpha-8 [KO:K06584]
394012  itga9; integrin alpha-9 [KO:K06585]
572348  itga10; integrin alpha-10 [KO:K06586]
541475  itga11a; integrin alpha-11a precursor [KO:K06587]
567175  itga11b; integrin alpha-11 [KO:K06587]
100151255  itgav; integrin alpha-V precursor [KO:K06487]
570216  itgb1b; integrin beta-1b precursor [KO:K05719]
556734  itgb1a; integrin beta-1a precursor [KO:K05719]
100001836  itgb3b; integrin beta-3b precursor [KO:K06493]
564266  itgb3a; integrin beta-3a precursor [KO:K06493]
335269  itgb4; integrin beta-4 precursor [KO:K06525]
563556  itgb5; integrin beta-5 [KO:K06588]
100499533  itgb6; integrin beta-6 [KO:K06589]
797491  itgb7; integrin beta-7 [KO:K06590]
556752  itgb8; integrin beta-8 [KO:K06591]
445506  emp2; epithelial membrane protein 2 [KO:K26256]
378480  pdgfaa; platelet-derived growth factor alpha polypeptide a precursor [KO:K04359]
767790  pdgfab; platelet-derived growth factor alpha polypeptide b precursor [KO:K04359]
796490  pdgfbb; uncharacterized protein pdgfbb isoform X2 [KO:K04359]
103909601  platelet-derived growth factor subunit A [KO:K04359]
798657  pdgfba; platelet-derived growth factor beta polypeptide a precursor [KO:K17386]
560564  pdgfc; platelet-derived growth factor C isoform X2 [KO:K05450]
100535718  pdgfd; platelet-derived growth factor D [KO:K05450]
403045  egf; pro-epidermal growth factor isoform 1 precursor [KO:K04357]
114433  igf1; insulin-like growth factor I precursor [KO:K05459]
30682  vegfaa; vascular endothelial growth factor A-A isoform 1 precursor [KO:K05448]
558154  vegfab; vascular endothelial growth factor Ab isoform 1 precursor [KO:K05448]
557468  pgfb; placenta growth factor isoform X1 [KO:K16859]
101883508  pgfa; placenta growth factor-like [KO:K16859]
403049  vegfc; vascular endothelial growth factor C precursor [KO:K05449]
678512  vegfd; vascular endothelial growth factor D precursor [KO:K05449]
493781  hgfa; hepatocyte growth factor a precursor [KO:K05460]
100334116  hepatocyte growth factor-like [KO:K05460]
386856  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
559529  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
245701  igf1ra; insulin-like growth factor 1a receptor precursor [KO:K05087] [EC:2.7.10.1]
245702  igf1rb; insulin-like growth factor 1b receptor precursor [KO:K05087] [EC:2.7.10.1]
554230  kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
378478  egfra; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
571431  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
544667  flt1; vascular endothelial growth factor receptor 1 isoform 1 precursor [KO:K05096] [EC:2.7.10.1]
796537  kdrl; vascular endothelial growth factor receptor kdr-like precursor [KO:K05096] [EC:2.7.10.1]
30121  flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
100150664  met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
386966  erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
100318165  emp1; epithelial membrane protein 1 [KO:K26255]
325084  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100004299  rho GTPase-activating protein 35 [KO:K05732]
564565  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
795752  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
406411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
406659  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
436718  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
751630  zgc:153713; RhoA_like domain-containing protein [KO:K04513]
100006041  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
101886015  protein diaphanous homolog 1-like [KO:K05740]
100329779  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
317747  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
321070  rock2b; rho-associated protein kinase 2b [KO:K17388] [EC:2.7.11.1]
677750  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
100537244  myl2a; myosin regulatory light chain 2a [KO:K10351]
30592  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
406493  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
450006  myl9a; uncharacterized protein LOC450006 [KO:K12755]
550569  myl10; myosin regulatory light chain 10 [KO:K12756]
337084  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
326719  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
447930  mylpfb; myosin regulatory light chain 2, skeletal muscle isoform B [KO:K12758]
30429  mylpfa; myosin regulatory light chain 2, skeletal muscle isoform A [KO:K12758]
327301  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
407980  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
334597  ppp1cbl; protein phosphatase 1, catalytic subunit, beta isoform, like [KO:K06269] [EC:3.1.3.16]
100003223  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
571753  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
445393  ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
571837  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
101885790  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
570218  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
561635  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
558685  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
492576  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
569510  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
449707  mylk4b; myosin light chain kinase family member 4 isoform X4 [KO:K00907] [EC:2.7.11.18]
566845  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X2 [KO:K00907] [EC:2.7.11.18]
100003770  mylk5; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
449831  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
553629  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
492549  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
447840  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
798876  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
100005033  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b [KO:K00889] [EC:2.7.1.68]
57934  actb1; actin, cytoplasmic 1 [KO:K05692]
57935  actb2; actin, cytoplasmic 2 [KO:K05692]
568885  si:ch211-234p18.3; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
541374  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
563053  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
337730  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
445091  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
322221  actn4; alpha-actinin-4 [KO:K05699]
560400  actn1; alpha-actinin-1 [KO:K05699]
494453  tln1; talin-1 [KO:K06271]
556842  tln2a; talin-2a [KO:K06271]
100333114  tln2b; talin-2 [KO:K06271]
562529  flna; filamin-A isoform X1 [KO:K04437]
100534866  flnb; filamin-B isoform X1 [KO:K27392]
563023  flnb; filamin-A isoform X1 [KO:K27392]
399546  pxna; paxillin a [KO:K05760]
565130  pxnb; paxillin-like isoform X6 [KO:K05760]
393543  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
564246  zyx; zyxin [KO:K06273]
550487  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
555805  vaspa; vasodilator stimulated phosphoprotein a [KO:K06274]
552980  vcla; vinculin a [KO:K05700]
100334859  vclb; vinculin b [KO:K05700]
325686  parvb; beta-parvin [KO:K06275]
442922  parvaa; parvin, alpha a [KO:K06275]
100037387  parvg; gamma-parvin [KO:K06275]
567123  parvab; parvin, alpha b [KO:K06275]
403000  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
768202  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a precursor [KO:K06276] [EC:2.7.11.1]
403146  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
560549  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
378972  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100149794  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101910198  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
30654  gsk3ba; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
557882  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
30265  ctnnb1; catenin beta-1 [KO:K02105]
324004  ctnnb2; catenin, beta 2 [KO:K02105]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
100333967  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100003514  prkcg; protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
142986  ptk2ab; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
386705  ptk2aa; protein tyrosine kinase 2aa [KO:K05725] [EC:2.7.10.2]
394174  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
561737  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100002263  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
404211  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100000252  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
557176  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
368415  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
794088  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
559145  vav3b; guanine nucleotide exchange factor VAV3b [KO:K05730]
556413  vav2; guanine nucleotide exchange factor VAV2 isoform X8 [KO:K05730]
100333179  vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
327204  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
792699  rac1l; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
562838  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
100537765  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
415151  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
437027  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
795167  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
373103  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
266749  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
325034  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
431769  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
405898  pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
567874  pak6b; serine/threonine-protein kinase PAK 6b [KO:K05735] [EC:2.7.11.1]
100536197  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
336839  cdc42; cell division control protein 42 homolog isoform 2 [KO:K04393]
556226  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
793158  cdc42l; cell division cycle 42, like [KO:K04393]
568309  bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
445234  crk; adapter molecule crk [KO:K04438]
556443  crkl; crk-like protein [KO:K04438]
572187  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
394101  rapgef1b; rap guanine nucleotide exchange factor 1b [KO:K06277]
558635  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
415242  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
406714  rap1ab; ras-related protein rap1ab [KO:K04353]
321107  rap1b; ras-related protein Rap-1b [KO:K07836]
569698  mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
562720  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
65236  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100149273  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
335916  jun; transcription factor AP-1 [KO:K04448]
403065  braf; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
323695  cav1; caveolin-1 isoform b [KO:K06278]
415240  cav2; caveolin-2 [KO:K12958]
791212  cav4b; uncharacterized protein LOC791212 [KO:K12958]
100136849  cav4a; uncharacterized protein LOC100136849 [KO:K12958]
449679  cav3; caveolin-3 [KO:K12959]
574422  fynb; tyrosine-protein kinase fynb [KO:K05703] [EC:2.7.10.2]
373872  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
323818  shc1; SHC-transforming protein 1 isoform X3 [KO:K06279]
562011  shc2; SHC-transforming protein 2 [KO:K17447]
100332111  shc3; SHC-transforming protein 3 [KO:K17448]
406308  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
493609  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
561670  sos2; son of sevenless homolog 2 [KO:K03099]
556286  sos1; son of sevenless homolog 1 [KO:K03099]
553656  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
550286  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
30716  raf1a; Raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
557109  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
406728  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
360144  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399480  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
567895  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
30222  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
799608  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
565038  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
449996  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
373107  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
373108  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
58100  badb; BCL2 associated agonist of cell death b isoform 1 [KO:K02158]
564921  bada; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100007048  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
570772  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
dre04010  MAPK signaling pathway
dre04060  Cytokine-cytokine receptor interaction
dre04070  Phosphatidylinositol signaling system
dre04110  Cell cycle
dre04310  Wnt signaling pathway
dre04512  ECM-receptor interaction
dre04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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