KEGG   PATHWAY: gga04510
Entry
gga04510                    Pathway                                
Name
Focal adhesion - Gallus gallus (chicken)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gga04510  Focal adhesion
gga04510

Other DBs
GO: 0005925
Organism
Gallus gallus (chicken) [GN:gga]
Gene
100857227  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
100858156  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101748153  [KO:K06243]
101749098  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101749783  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101750560  [KO:K04456] [EC:2.7.11.1]
107049646  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
107049666  [KO:K06590]
107050724  [KO:K05730]
107054794  CRK; adapter molecule crk [KO:K04438]
107057642  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
373918  ACTN1; alpha-actinin-1 [KO:K05699]
373938  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
373939  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
373946  ITGA3; integrin alpha-3 precursor [KO:K06482]
373953  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
373970  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
373980  LAMB2; laminin subunit beta-1 variant precursor [KO:K06243]
373987  THBS1; thrombospondin-1 precursor [KO:K16857]
373996  CAV1; caveolin-1 [KO:K06278]
374012  BIRC2; inhibitor of apoptosis protein [KO:K16060]
374016  LAMA1; laminin subunit alpha-1 precursor [KO:K05637]
374018  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
374047  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
374058  ITGB1; integrin beta-1 precursor [KO:K05719]
374100  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
374128  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
374182  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
374196  PDGFA; platelet-derived growth factor subunit A preproprotein [KO:K04359]
374209  ITGB3; integrin beta-3 precursor [KO:K06493]
378796  CAV3; caveolin-3 [KO:K12959]
378913  FLNB; filamin-B [KO:K27392]
386572  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
395069  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
395142  ITGB5; integrin beta-5 precursor [KO:K06588]
395194  TLN1; talin-1 [KO:K06271]
395210  SPP1; osteopontin precursor [KO:K06250]
395255  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
395261  FLNA; filamin-A [KO:K04437]
395280  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
395323  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
395442  RHOA; transforming protein RhoA [KO:K04513]
395469  PDGFC; platelet-derived growth factor C precursor [KO:K05450]
395470  ITGB8; integrin beta-8 isoform X3 [KO:K06591]
395478  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
395509  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
395530  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
395532  COL1A1; collagen alpha-1(I) chain [KO:K06236]
395742  FLT4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
395832  PXN; paxillin [KO:K05760]
395870  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
395871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
395889  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
395909  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
395917  CDC42; cell division control protein 42 homolog precursor [KO:K04393]
395928  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
395934  SHC1; SHC-transforming protein 1 [KO:K06279]
395935  VTN; vitronectin precursor [KO:K06251]
395941  HGF; hepatocyte growth factor precursor [KO:K05460]
395951  ITGA1; integrin alpha-1 precursor [KO:K06480]
395963  CAPN2; calpain-2 catalytic subunit precursor [KO:K03853] [EC:3.4.22.53]
395964  CTNNB1; catenin beta-1 [KO:K02105]
395983  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
396000  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
396019  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
396020  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
396024  ACTN4; alpha-actinin-4 [KO:K05699]
396071  IBSP; bone sialoprotein 2 precursor [KO:K06253]
396076  LAMB4; laminin subunit beta-4 [KO:K06245]
396106  TNX; tenascin-X isoform X4 [KO:K06252]
396133  FN1; fibronectin precursor [KO:K05717]
396134  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
396213  TNR; tenascin-R precursor [KO:K06252]
396215  MYL9; myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755]
396225  ITGA8; integrin alpha-8 precursor [KO:K06584]
396226  ITGA6; integrin alpha-6 precursor [KO:K06485]
396229  HRAS; GTPase HRas precursor [KO:K02833]
396239  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
396242  COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131]
396243  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
396245  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
396282  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
396284  MYL12A; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
396292  COL6A2; collagen alpha-2(VI) chain precursor [KO:K06238]
396294  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
396306  THBS4; thrombospondin 4 precursor [KO:K04659]
396341  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
396356  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
396416  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
396420  ITGAV; integrin alpha-V precursor [KO:K06487]
396422  VCL; vinculin [KO:K05700]
396440  TNC; tenascin precursor [KO:K06252]
396442  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
396445  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
396478  LAMB1; laminin subunit beta-1 [KO:K05636]
396494  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
396524  COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131]
396526  ACTB; actin, cytoplasmic 1 [KO:K05692]
396548  COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238]
408035  EGF; pro-epidermal growth factor precursor [KO:K04357]
408043  LAMC2; laminin subunit gamma-2 [KO:K06246]
414837  THBS2; thrombospondin-2 precursor [KO:K04659]
415296  ACTG1; actin, cytoplasmic type 5 [KO:K05692]
415374  TLN2; talin-2 [KO:K06271]
415549  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
415560  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
415578  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
415691  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
415748  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
416567  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
416588  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
416636  EMP2; epithelial membrane protein 2 [KO:K26256]
416734  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
416872  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
416874  MYL2; myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351]
416939  CRKL; crk-like protein [KO:K04438]
417173  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
417180  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
417374  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
417430  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
417506  MYL10; myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
417772  CAV2; caveolin-2 [KO:K12958]
417840  RAP1B; ras-related protein Rap-1b precursor [KO:K07836]
417964  EMP1; epithelial membrane protein 1 [KO:K26255]
418044  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
418090  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
418235  PARVB; beta-parvin isoform X2 [KO:K06275]
418236  PARVG; gamma-parvin [KO:K06275]
418300  ZYX; zyxin [KO:K06273]
418335  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
418752  COL4A2; collagen alpha-2(IV) chain precursor [KO:K06237]
418978  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
419031  VWF; von Willebrand factor precursor [KO:K03900]
419083  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
419444  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
419867  RAP1A; ras-related protein Rap-1A [KO:K04353]
419928  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
420072  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
420120  COMP; cartilage oligomeric matrix protein [KO:K04659]
420757  ITGA9; integrin alpha-9 precursor [KO:K06585]
420893  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
421497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
421709  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
421749  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
422316  VEGFRKDRL; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
422342  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
422348  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
422350  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
422573  VEGFC; vascular endothelial growth factor C [KO:K05449]
422592  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
423030  PARVA; alpha-parvin isoform X3 [KO:K06275]
423572  SOS2; son of sevenless homolog 2 [KO:K03099]
423675  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
423778  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
423960  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
424121  ITGA4; integrin alpha-4 [KO:K06483]
424191  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
424435  TNN; tenascin-N [KO:K06252]
424442  LAMC1; laminin subunit gamma-1 [KO:K05635]
424673  JUN; transcription factor AP-1 [KO:K04448]
424797  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
424799  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
424826  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
424860  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
424971  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
425730  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
426130  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
426482  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
427171  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
427243  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
427850  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
428148  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
428268  LAMB3; laminin subunit beta-3 [KO:K06244]
428278  MYLKSML; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
428448  COL6A6; collagen alpha-6(VI) chain isoform X2 [KO:K06238]
428524  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
428837  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
428883  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
429096  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
429983  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
431192  SOS1; son of sevenless homolog 1 [KO:K03099]
431265  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
769665  CHAD; chondroadherin [KO:K06248]
770011  MYL12B; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
770341  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
770462  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
770488  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
771142  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
771832  PGF; placenta growth factor [KO:K16859]
771873  COL9A1; collagen alpha-1(IX) chain precursor [KO:K08131]
776775  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
776816  [KO:K05692]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
gga04010  MAPK signaling pathway
gga04060  Cytokine-cytokine receptor interaction
gga04070  Phosphatidylinositol signaling system
gga04110  Cell cycle
gga04310  Wnt signaling pathway
gga04512  ECM-receptor interaction
gga04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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