KEGG   PATHWAY: gga04810
Entry
gga04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Gallus gallus (chicken)
Class
Cellular Processes; Cell motility
Pathway map
gga04810  Regulation of actin cytoskeleton
gga04810

Other DBs
GO: 0030036
Organism
Gallus gallus (chicken) [GN:gga]
Gene
427339  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
426086  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
422149  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
418279  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
395180  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
395324  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
395306  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
427212  F2R; proteinase-activated receptor 1 isoform X4 [KO:K03914]
396145  INS-IGF2; insulin preproinsulin precursor [KO:K04526]
408035  EGF; pro-epidermal growth factor precursor [KO:K04357]
396094  FGF1; fibroblast growth factor 1 precursor [KO:K18496]
396413  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
422330  FGF16; fibroblast growth factor 16 [KO:K04358]
428779  FGF20; fibroblast growth factor 20 [KO:K04358]
768907  FGF6; fibroblast growth factor 6 [KO:K04358]
378917  FGF9; fibroblast growth factor 9 [KO:K04358]
770457  FGF5; fibroblast growth factor 5 isoform X2 [KO:K04358]
415439  FGF7; fibroblast growth factor 7 [KO:K04358]
396267  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
428857  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
395453  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
396313  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
395432  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
100858338  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
395394  FGF19; fibroblast growth factor 19 precursor [KO:K22603]
428104  FGF23; fibroblast growth factor 23 [KO:K22428]
374196  PDGFA; platelet-derived growth factor subunit A preproprotein [KO:K04359]
374128  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
395469  PDGFC; platelet-derived growth factor C precursor [KO:K05450]
418978  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
100857811  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
396494  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
396516  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
396259  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
396515  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
395603  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
395509  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
770488  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
396133  FN1; fibronectin precursor [KO:K05717]
395951  ITGA1; integrin alpha-1 precursor [KO:K06480]
100857227  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101749783  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
373946  ITGA3; integrin alpha-3 precursor [KO:K06482]
424121  ITGA4; integrin alpha-4 [KO:K06483]
396226  ITGA6; integrin alpha-6 precursor [KO:K06485]
101749098  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
396225  ITGA8; integrin alpha-8 precursor [KO:K06584]
420757  ITGA9; integrin alpha-9 precursor [KO:K06585]
415560  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
396420  ITGAV; integrin alpha-V precursor [KO:K06487]
374058  ITGB1; integrin beta-1 precursor [KO:K05719]
396181  ITGB2; integrin beta-2 precursor [KO:K06464]
374209  ITGB3; integrin beta-3 precursor [KO:K06493]
417374  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
395142  ITGB5; integrin beta-5 precursor [KO:K06588]
424191  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
107049666  integrin beta-7 [KO:K06590]
395470  ITGB8; integrin beta-8 isoform X3 [KO:K06591]
424957  KNG1; kininogen-1 [KO:K03898]
772372  BDKRB1; B1 bradykinin receptor [KO:K03915]
428906  BDKRB2; B2 bradykinin receptor [KO:K03916]
418126  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
396364  CHRM1; muscarinic acetylcholine receptor M3 [KO:K04131]
423195  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
428881  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
417122  C5; complement C5 isoform X2 [KO:K03994]
431585  C6; complement component C6 precursor [KO:K03995]
427187  C7; complement component C7 precursor [KO:K03996]
429111  C8A; complement component C8 alpha chain [KO:K03997]
424669  C8B; complement component C8 beta chain precursor [KO:K03998]
770691  C8G; complement component C8 gamma chain [KO:K03999]
769924  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
417434  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
772239  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
415989  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X9 [KO:K05722]
396416  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
415691  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
416939  CRKL; crk-like protein [KO:K04438]
107054794  CRK; adapter molecule crk [KO:K04438]
423960  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
396442  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
423572  SOS2; son of sevenless homolog 2 [KO:K03099]
431192  SOS1; son of sevenless homolog 1 [KO:K03099]
396229  HRAS; GTPase HRas precursor [KO:K02833]
418207  KRAS; GTPase KRas [KO:K07827]
419885  NRAS; GTPase NRas precursor [KO:K07828]
423062  RRAS2; ras-related protein R-Ras2 [KO:K07830]
395149  MRAS; ras-related protein M-Ras [KO:K07831]
422247  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
424971  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
419444  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
424826  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
429096  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
771142  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
427171  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
373939  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
373938  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
107050724  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
418491  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
396239  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
396245  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
428537  MOS; serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
415549  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
396349  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
373953  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
395928  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
421497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101750560  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
418833  RGCC; regulator of cell cycle RGCC isoform X2 [KO:K26108]
422284  RGCCL; regulator of cell cycle RGCC [KO:K26108]
419752  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
425730  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
395442  RHOA; transforming protein RhoA [KO:K04513]
395871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
418044  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
395870  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
395917  CDC42; cell division control protein 42 homolog precursor [KO:K04393]
419083  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
424860  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
422342  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
770462  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
416734  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
428837  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
418761  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
417584  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
373970  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
374182  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
415748  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
396445  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
396356  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
428278  MYLKSML; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
420893  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
396019  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
416872  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100858156  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
396020  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
395478  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
107049646  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
416874  MYL2; myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351]
396215  MYL9; myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755]
417506  MYL10; myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
396284  MYL12A; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
770011  MYL12B; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
776775  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
396211  MYH11; myosin-11 [KO:K10352]
396465  MYH10; myosin-10 [KO:K10352]
396469  MYH9; myosin-9 [KO:K10352]
374040  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
419580  SLC9A1; sodium/hydrogen exchanger 1 precursor [KO:K05742]
427243  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
420072  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
429983  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
420504  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
419999  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
424114  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
373922  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
396010  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
418824  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
422077  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
374180  ENAH; protein enabled homolog [KO:K05746]
417750  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
426359  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
416246  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
418677  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
424000  NCKAP1; nck-associated protein 1 isoform X5 [KO:K05750]
425499  NCKAP1L; nck-associated protein 1-like [KO:K05750]
424108  ABI2; abl interactor 2 isoform X11 [KO:K05751]
107054369  BRK1; protein BRICK1 [KO:K05752]
421761  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
396147  ACTR2; actin-related protein 2 [KO:K17260]
420439  ACTR3B; actin-related protein 3B isoform X2 [KO:K18584]
374197  ACTR3; actin-related protein 3 [KO:K18584]
416490  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
770269  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
429041  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
416837  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
416051  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
429075  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101752218  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
776816  actin, cytoplasmic 2 [KO:K05692]
415296  ACTG1; actin, cytoplasmic type 5 [KO:K05692]
396526  ACTB; actin, cytoplasmic 1 [KO:K05692]
428564  PFN3; profilin-3 [KO:K05759]
771904  PFN1; profilin-2 [KO:K05759]
107053160  PFN4; profilin-4 [KO:K05759]
395832  PXN; paxillin [KO:K05760]
395701  EZR; ezrin [KO:K08007]
395511  RDX; radixin [KO:K05762]
408047  TMSB4X; thymosin beta-4 [KO:K05764]
770993  TMSB4Y; thymosin beta-12 [KO:K05764]
423320  CFL2; cofilin-2 [KO:K05765]
417586  SSH2; protein phosphatase Slingshot homolog 2 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101750781  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101752044  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
396422  VCL; vinculin [KO:K05700]
415591  IQGAP3; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
427211  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
101749531  RGI3L1; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP3 [KO:K05767]
395774  GSN; gelsolin precursor [KO:K05768]
420588  SCIN; adseverin [KO:K05768]
373918  ACTN1; alpha-actinin-1 [KO:K05699]
396024  ACTN4; alpha-actinin-4 [KO:K05699]
415607  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
429363  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
424761  ARHGEF4; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 4 [KO:K05769]
418940  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
gga04010  MAPK signaling pathway
gga04510  Focal adhesion
gga04520  Adherens junction
KO pathway
ko04810   
LinkDB

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