KEGG   PATHWAY: hmg04150
Entry
hmg04150                    Pathway                                
Name
mTOR signaling pathway - Hydra vulgaris (swiftwater hydra)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
hmg04150  mTOR signaling pathway
hmg04150

Organism
Hydra vulgaris (swiftwater hydra) [GN:hmg]
Gene
100198966  sodium-coupled neutral amino acid transporter 9 [KO:K14995]
100198784  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
100203652  V-type proton ATPase subunit B [KO:K02147]
100209803  V-type proton ATPase subunit C [KO:K02148]
100209716  V-type proton ATPase subunit E [KO:K02150]
100206169  probable V-type proton ATPase subunit F [KO:K02151]
100213508  V-type proton ATPase subunit G [KO:K02152]
100211029  V-type proton ATPase subunit H [KO:K02144]
101239814  ragulator complex protein LAMTOR1 [KO:K20397]
100203620  ragulator complex protein LAMTOR2-like [KO:K20398]
100199419  ragulator complex protein LAMTOR3-A [KO:K04370]
101241404  ragulator complex protein LAMTOR4 homolog [KO:K20399]
101238286  folliculin [KO:K09594]
100215551  folliculin-interacting protein 1 isoform X1 [KO:K20401]
100213179  ras-related GTP-binding protein A [KO:K16185]
100209939  ras-related GTP-binding protein C [KO:K16186]
100205284  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
101237679  GATOR complex protein MIOS-B [KO:K20407]
100206230  nucleoporin SEH1 [KO:K14299]
100210968  GATOR complex protein WDR24 [KO:K20408]
101239697  GATOR complex protein WDR59-like [KO:K20409]
100197913  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
100197551  GATOR complex protein NPRL2 [KO:K20405]
100213346  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
101236554  S-phase kinase-associated protein 2 [KO:K03875]
100213041  regulatory-associated protein of mTOR [KO:K07204]
100206382  uncharacterized protein LOC100206382 [KO:K16184]
100197178  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100199791  DEP domain-containing mTOR-interacting protein [KO:K20402]
100198452  target of rapamycin complex subunit lst8-like [KO:K08266]
101237927  telomere length regulation protein TEL2 homolog [KO:K11137]
100198969  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
101239291  growth factor receptor-bound protein 14 isoform X1 [KO:K20064]
100214900  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100212126  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
100214157  eukaryotic translation initiation factor 4E-1A [KO:K03259]
101238393  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100209609  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100215411  eukaryotic translation initiation factor 4B [KO:K03258]
100200285  40S ribosomal protein S6 [KO:K02991]
100200686  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100213010  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
100209595  calcium-binding protein 39 [KO:K08272]
101238049  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100204754  hamartin-like [KO:K07206]
100197539  tuberin isoform X1 [KO:K07207]
100204955  TBC1 domain family member 7 [KO:K20396]
100205860  GTP-binding protein Rheb [KO:K07208]
100204240  hywnt1; protein Wnt-1 isoform X1 [KO:K03209]
100215038  hywnt9/10a; protein Wnt-1 [KO:K00182]
100214868  hywnt7; protein Wnt-2b [KO:K00182]
100203050  proto-oncogene Wnt-3-like precursor [KO:K00312]
100207084  hywnt16; protein Wnt-4 [KO:K00408]
100202930  hywnt5a; secreted signaling factor Wnt5a [KO:K00444]
100214773  hywnt9/10c; protein Wnt-1 [KO:K00572]
100198339  hywnt9/10b; protein Wnt-7b isoform X2 [KO:K00572]
100200795  hywnt8; secreted signaling factor Wnt8 precursor [KO:K00714]
100197163  hywnt11; protein Wnt-4 [KO:K01384]
100204108  frizzled-1-like precursor [KO:K02432]
100192247  frizzled-4 [KO:K02354]
100192248  hyfzd5/8; frizzled5/8 precursor [KO:K02375]
100198234  low-density lipoprotein receptor-related protein 6 [KO:K03068]
100198100  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
100205784  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
100203080  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
100214733  putative insulin-like peptide receptor precursor [KO:K05087] [EC:2.7.10.1]
100199343  growth factor receptor-bound protein 2 [KO:K04364]
100196975  son of sevenless homolog 2 [KO:K03099]
100209445  ras-like protein RAS1 [KO:K07827]
100210556  GTPase NRas [KO:K07827]
105845433  ras-like protein 1 [KO:K07827]
100201878  serine/threonine-protein kinase A-Raf [KO:K04365] [EC:2.7.11.1]
100213114  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04369] [EC:2.7.12.2]
100204895  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100202283  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
100210375  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101239852  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100205574  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105843936  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100200349  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100210496  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100207607  inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K04467] [EC:2.7.11.10]
100214433  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
100206050  proline-rich protein 5 isoform X1 [KO:K20411]
100204217  ras-like GTP-binding protein RHO [KO:K04513]
100200732  ras-like GTP-binding protein Rho1 [KO:K04513]
100207737  ras-like GTP-binding protein Rho1 [KO:K04513]
105849760  ras-like GTP-binding protein RHO [KO:K04513]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
hmg00561  Glycerolipid metabolism
hmg04140  Autophagy - animal
KO pathway
ko04150   
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