KEGG   PATHWAY: hsa00513
Entry
hsa00513                    Pathway                                
Name
Various types of N-glycan biosynthesis - Homo sapiens (human)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
hsa00513  Various types of N-glycan biosynthesis
hsa00513

Module
hsa_M00072  N-glycosylation by oligosaccharyltransferase [PATH:hsa00513]
Other DBs
GO: 0006487
Organism
Homo sapiens (human) [GN:hsa]
Gene
10195  ALG3; ALG3 alpha-1,3- mannosyltransferase [KO:K03845] [EC:2.4.1.258]
10905  MAN1A2; mannosidase alpha class 1A member 2 [KO:K01230] [EC:3.2.1.113]
11253  MAN1B1; mannosidase alpha class 1B member 1 [KO:K23741]
11282  MGAT4B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [KO:K00738] [EC:2.4.1.145]
11320  MGAT4A; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A [KO:K00738] [EC:2.4.1.145]
152586  MGAT4D; MGAT4 family member D [KO:K00738] [EC:2.4.1.145]
1603  DAD1; defender against cell death 1 [KO:K12668]
1650  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [KO:K12670]
199857  ALG14; ALG14 UDP-N-acetylglucosaminyltransferase subunit [KO:K07441] [EC:2.4.1.141]
200185  KRTCAP2; keratinocyte associated protein 2 [KO:K28202]
201595  STT3B; STT3 oligosaccharyltransferase complex catalytic subunit B [KO:K07151] [EC:2.4.99.18]
2530  FUT8; fucosyltransferase 8 [KO:K00717] [EC:2.4.1.68]
25834  MGAT4C; MGAT4 family member C [KO:K13748] [EC:2.4.1.201 2.4.1.145]
2683  B4GALT1; beta-1,4-galactosyltransferase 1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
283358  B4GALNT3; beta-1,4-N-acetyl-galactosaminyltransferase 3 [KO:K09656] [EC:2.4.1.244]
284004  HEXD; hexosaminidase D [KO:K14459] [EC:3.2.1.52]
3073  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
3074  HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
338707  B4GALNT4; beta-1,4-N-acetyl-galactosaminyltransferase 4 [KO:K09657] [EC:2.4.1.244]
3703  STT3A; STT3 oligosaccharyltransferase complex catalytic subunit A [KO:K07151] [EC:2.4.99.18]
4121  MAN1A1; mannosidase alpha class 1A member 1 [KO:K01230] [EC:3.2.1.113]
4122  MAN2A2; mannosidase alpha class 2A member 2 [KO:K01231] [EC:3.2.1.114]
4124  MAN2A1; mannosidase alpha class 2A member 1 [KO:K01231] [EC:3.2.1.114]
4245  MGAT1; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [KO:K00726] [EC:2.4.1.101]
4247  MGAT2; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [KO:K00736] [EC:2.4.1.143]
440138  ALG11; ALG11 alpha-1,2-mannosyltransferase [KO:K03844] [EC:2.4.1.131]
56052  ALG1; ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [KO:K03842] [EC:2.4.1.142]
57134  MAN1C1; mannosidase alpha class 1C member 1 [KO:K01230] [EC:3.2.1.113]
58505  OSTC; oligosaccharyltransferase complex non-catalytic subunit [KO:K26501]
6184  RPN1; ribophorin I [KO:K12666]
6185  RPN2; ribophorin II [KO:K12667]
64377  CHST8; carbohydrate sulfotransferase 8 [KO:K09672] [EC:2.8.2.-]
6487  ST3GAL3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [KO:K00781] [EC:2.4.3.6]
746  TMEM258; transmembrane protein 258 [KO:K26502]
79087  ALG12; ALG12 alpha-1,6-mannosyltransferase [KO:K03847] [EC:2.4.1.260]
79796  ALG9; ALG9 alpha-1,2-mannosyltransferase [KO:K03846] [EC:2.4.1.259 2.4.1.261]
79868  ALG13; ALG13 UDP-N-acetylglucosaminyltransferase subunit [KO:K07432] [EC:2.4.1.141]
7991  TUSC3; tumor suppressor candidate 3 [KO:K19478]
83539  CHST9; carbohydrate sulfotransferase 9 [KO:K09673] [EC:2.8.2.-]
84061  MAGT1; magnesium transporter 1 [KO:K19478]
85365  ALG2; ALG2 alpha-1,3/1,6-mannosyltransferase [KO:K03843] [EC:2.4.1.132 2.4.1.257]
8703  B4GALT3; beta-1,4-galactosyltransferase 3 [KO:K07968] [EC:2.4.1.90 2.4.1.38 2.4.1.-]
8704  B4GALT2; beta-1,4-galactosyltransferase 2 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
Compound
G00011  
G00012  
G00013  
G00014  
G00015  
G00016  Core fucose
G00017  
G00179  
G01813  
G05477  
G10665  
G10694  
G10716  
G10770  
G10841  
G10920  
G11000  
G11040  
G11933  
G12617  
G12625  
G12626  
G13047  
G13048  
G13049  
G13050  
G13055  
G13056  
G13057  
G13058  
G13059  
Reference
PMID:11412862
  Authors
Munro S.
  Title
What can yeast tell us about N-linked glycosylation in the Golgi apparatus?
  Journal
FEBS Lett 498:223-7 (2001)
DOI:10.1016/S0014-5793(01)02488-7
Reference
PMID:9878803
  Authors
Dean N.
  Title
Asparagine-linked glycosylation in the yeast Golgi.
  Journal
Biochim Biophys Acta 1426:309-22 (1999)
DOI:10.1016/S0304-4165(98)00132-9
Reference
PMID:9878780
  Authors
Herscovics A.
  Title
Processing glycosidases of Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1426:275-85 (1999)
DOI:10.1016/S0304-4165(98)00129-9
Reference
PMID:9218445
  Authors
Wang XH, Nakayama K, Shimma Y, Tanaka A, Jigami Y.
  Title
MNN6, a member of the KRE2/MNT1 family, is the gene for mannosylphosphate transfer in Saccharomyces cerevisiae.
  Journal
J Biol Chem 272:18117-24 (1997)
DOI:10.1074/jbc.272.29.18117
Reference
PMID:9756928
  Authors
Rayner JC, Munro S.
  Title
Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae.
  Journal
J Biol Chem 273:26836-43 (1998)
DOI:10.1074/jbc.273.41.26836
Reference
PMID:10037752
  Authors
Jungmann J, Rayner JC, Munro S.
  Title
The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex.
  Journal
J Biol Chem 274:6579-85 (1999)
DOI:10.1074/jbc.274.10.6579
Reference
PMID:8253757
  Authors
Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y.
  Title
Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.
  Journal
J Biol Chem 268:26338-45 (1993)
Reference
PMID:20233335
  Authors
Gomord V, Fitchette AC, Menu-Bouaouiche L, Saint-Jore-Dupas C, Plasson C, Michaud D, Faye L
  Title
Plant-specific glycosylation patterns in the context of therapeutic protein production.
  Journal
Plant Biotechnol J 8:564-87 (2010)
DOI:10.1111/j.1467-7652.2009.00497.x
Related
pathway
hsa00510  N-Glycan biosynthesis
KO pathway
ko00513   

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