KEGG   PATHWAY: hsa03420
Entry
hsa03420                    Pathway                                
Name
Nucleotide excision repair - Homo sapiens (human)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
hsa03420  Nucleotide excision repair
hsa03420

Network
nt06502  Nucleotide excision repair
  Element
N01425  Global genome NER
N01430  Transcription-coupled NER
N01431  Core NER reaction
Other DBs
GO: 0006289
Organism
Homo sapiens (human) [GN:hsa]
Gene
100533467  BIVM-ERCC5; BIVM-ERCC5 readthrough [KO:K10846]
1022  CDK7; cyclin dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
1069  CETN2; centrin 2 [KO:K10840]
10714  POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
1161  ERCC8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit [KO:K10570]
1642  DDB1; damage specific DNA binding protein 1 [KO:K10610]
1643  DDB2; damage specific DNA binding protein 2 [KO:K10140]
2067  ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit [KO:K10849]
2068  ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit [KO:K10844] [EC:5.6.2.3]
2071  ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit [KO:K10843] [EC:5.6.2.4]
2072  ERCC4; ERCC excision repair 4, endonuclease catalytic subunit [KO:K10848] [EC:3.1.-.-]
2073  ERCC5; ERCC excision repair 5, endonuclease [KO:K10846]
2074  ERCC6; ERCC excision repair 6, chromatin remodeling factor [KO:K10841]
246721  POLR2J2; RNA polymerase II subunit J2 [KO:K03008]
2965  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
2966  GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]
2967  GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]
2968  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
29935  RPA4; replication protein A4 [KO:K10741]
3978  LIG1; DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
404672  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
4331  MNAT1; MNAT1 component of CDK activating kinase [KO:K10842]
5111  PCNA; proliferating cell nuclear antigen [KO:K04802]
54107  POLE3; DNA polymerase epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
5424  POLD1; DNA polymerase delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425  POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
5426  POLE; DNA polymerase epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
5427  POLE2; DNA polymerase epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
5430  POLR2A; RNA polymerase II subunit A [KO:K03006] [EC:2.7.7.6]
5431  POLR2B; RNA polymerase II subunit B [KO:K03010] [EC:2.7.7.6]
5432  POLR2C; RNA polymerase II subunit C [KO:K03011]
5433  POLR2D; RNA polymerase II subunit D [KO:K03012]
5434  POLR2E; RNA polymerase II, I and III subunit E [KO:K03013]
5435  POLR2F; RNA polymerase II, I and III subunit F [KO:K03014]
5436  POLR2G; RNA polymerase II subunit G [KO:K03015]
5437  POLR2H; RNA polymerase II, I and III subunit H [KO:K03016]
5438  POLR2I; RNA polymerase II subunit I [KO:K03017]
5439  POLR2J; RNA polymerase II subunit J [KO:K03008]
5440  POLR2K; RNA polymerase II, I and III subunit K [KO:K03009]
5441  POLR2L; RNA polymerase II, I and III subunit L [KO:K03007]
548644  POLR2J3; RNA polymerase II subunit J3 [KO:K03008]
56655  POLE4; DNA polymerase epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
57654  UVSSA; UV stimulated scaffold protein A [KO:K23720]
57804  POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505]
5886  RAD23A; RAD23 homolog A, nucleotide excision repair protein [KO:K10839]
5887  RAD23B; RAD23 homolog B, nucleotide excision repair protein [KO:K10839]
5981  RFC1; replication factor C subunit 1 [KO:K10754]
5982  RFC2; replication factor C subunit 2 [KO:K10755]
5983  RFC3; replication factor C subunit 3 [KO:K10756]
5984  RFC4; replication factor C subunit 4 [KO:K10755]
5985  RFC5; replication factor C subunit 5 [KO:K10756]
6117  RPA1; replication protein A1 [KO:K07466]
6118  RPA2; replication protein A2 [KO:K10739]
6119  RPA3; replication protein A3 [KO:K10740]
728340  GTF2H2C; GTF2H2 family member C [KO:K03142]
730394  GTF2H2C_2; GTF2H2 family member C, copy 2 [KO:K03142]
7507  XPA; XPA, DNA damage recognition and repair factor [KO:K10847]
7508  XPC; XPC complex subunit, DNA damage recognition and repair factor [KO:K10838]
81488  POLR2M; RNA polymerase II subunit M [KO:K21987]
8450  CUL4B; cullin 4B [KO:K10609]
8451  CUL4A; cullin 4A [KO:K10609]
902  CCNH; cyclin H [KO:K06634]
9978  RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
hsa03020  RNA polymerase
hsa04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

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