KEGG   PATHWAY: hsa04392
Entry
hsa04392                    Pathway                                
Name
Hippo signaling pathway - multiple species - Homo sapiens (human)
Description
Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
Class
Environmental Information Processing; Signal transduction
Pathway map
hsa04392  Hippo signaling pathway - multiple species
hsa04392

Other DBs
GO: 0035329
Organism
Homo sapiens (human) [GN:hsa]
Gene
8642  DCHS1; dachsous cadherin-related 1 [KO:K16507]
54798  DCHS2; dachsous cadherin-related 2 [KO:K16507]
79633  FAT4; FAT atypical cadherin 4 [KO:K16669]
1454  CSNK1E; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
102800317  TPTEP2-CSNK1E; TPTEP2-CSNK1E readthrough [KO:K08960] [EC:2.7.11.1]
4771  NF2; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [KO:K16684]
23286  WWC1; WW and C2 domain containing 1 [KO:K16685]
79981  FRMD1; FERM domain containing 1 [KO:K16821]
122786  FRMD6; FERM domain containing 6 [KO:K16822]
11186  RASSF1; Ras association domain family member 1 [KO:K09850]
166824  RASSF6; Ras association domain family member 6 [KO:K09854]
6788  STK3; serine/threonine kinase 3 [KO:K04412]
60485  SAV1; salvador family WW domain containing protein 1 [KO:K16686]
26524  LATS2; large tumor suppressor kinase 2 [KO:K08791] [EC:2.7.11.1]
9113  LATS1; large tumor suppressor kinase 1 [KO:K08791] [EC:2.7.11.1]
55233  MOB1A; MOB kinase activator 1A [KO:K06685]
92597  MOB1B; MOB kinase activator 1B [KO:K06685]
8994  LIMD1; LIM domain containing 1 [KO:K16682]
84962  AJUBA; ajuba LIM protein [KO:K16682]
126374  WTIP; WT1 interacting protein [KO:K16682]
10413  YAP1; Yes1 associated transcriptional regulator [KO:K16687]
25937  WWTR1; WW domain containing transcription regulator 1 [KO:K16820]
7003  TEAD1; TEA domain transcription factor 1 [KO:K09448]
7004  TEAD4; TEA domain transcription factor 4 [KO:K09448]
7005  TEAD3; TEA domain transcription factor 3 [KO:K09448]
8463  TEAD2; TEA domain transcription factor 2 [KO:K09448]
9770  RASSF2; Ras association domain family member 2 [KO:K09851]
83937  RASSF4; Ras association domain family member 4 [KO:K09851]
5058  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
Reference
PMID:21415026
  Authors
Hilman D, Gat U
  Title
The evolutionary history of YAP and the hippo/YAP pathway.
  Journal
Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065
Reference
PMID:24715453
  Authors
Varelas X
  Title
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
  Journal
Development 141:1614-26 (2014)
DOI:10.1242/dev.102376
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:25966461
  Authors
Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL
  Title
The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.
  Journal
PLoS Biol 13:e1002146 (2015)
DOI:10.1371/journal.pbio.1002146
Reference
PMID:23396260
  Authors
Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y
  Title
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
  Journal
Exp Cell Res 319:931-45 (2013)
DOI:10.1016/j.yexcr.2013.01.020
Reference
PMID:23843471
  Authors
Yang Z, Hata Y
  Title
What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?
  Journal
J Biochem 154:207-9 (2013)
DOI:10.1093/jb/mvt060
Reference
PMID:24594661
  Authors
Hotz M, Barral Y
  Title
The Mitotic Exit Network: new turns on old pathways.
  Journal
Trends Cell Biol 24:145-52 (2014)
DOI:10.1016/j.tcb.2013.09.010
Reference
PMID:23579499
  Authors
Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A
  Title
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
  Journal
Science 340:871-5 (2013)
DOI:10.1126/science.1235822
Reference
PMID:22525225
  Authors
Hergovich A, Hemmings BA
  Title
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.
  Journal
Semin Cell Dev Biol 23:794-802 (2012)
DOI:10.1016/j.semcdb.2012.04.001
Reference
PMID:19826484
  Authors
Wang Y, Abu Irqeba A, Ayalew M, Suntay K
  Title
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.
  Journal
PLoS One 4:e7456 (2009)
DOI:10.1371/journal.pone.0007456
Related
pathway
hsa04390  Hippo signaling pathway
KO pathway
ko04392   
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