KEGG   PATHWAY: hsa05100
Entry
hsa05100                    Pathway                                
Name
Bacterial invasion of epithelial cells - Homo sapiens (human)
Description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
hsa05100  Bacterial invasion of epithelial cells
hsa05100

Organism
Homo sapiens (human) [GN:hsa]
Gene
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10096  ACTR3; actin related protein 3 [KO:K18584]
10097  ACTR2; actin related protein 2 [KO:K17260]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10163  WASF2; WASP family member 2 [KO:K05748]
10459  MAD2L2; mitotic arrest deficient 2 like 2 [KO:K13728]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10801  SEPTIN9; septin 9 [KO:K16938]
110117499  P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough [KO:K02649]
1211  CLTA; clathrin light chain A [KO:K04644]
1212  CLTB; clathrin light chain B [KO:K04645]
1213  CLTC; clathrin heavy chain [KO:K04646]
124404  SEPTIN12; septin 12 [KO:K16938]
1398  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
1399  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
1495  CTNNA1; catenin alpha 1 [KO:K05691]
1496  CTNNA2; catenin alpha 2 [KO:K05691]
1499  CTNNB1; catenin beta 1 [KO:K02105]
1731  SEPTIN1; septin 1 [KO:K13737]
1759  DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785  DNM2; dynamin 2 [KO:K23484]
1793  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
2017  CTTN; cortactin [KO:K06106]
23157  SEPTIN6; septin 6 [KO:K16939]
23176  SEPTIN8; septin 8 [KO:K16939]
2335  FN1; fibronectin 1 [KO:K05717]
23607  CD2AP; CD2 associated protein [KO:K13738]
2549  GAB1; GRB2 associated binding protein 1 [KO:K09593]
25759  SHC2; SHC adaptor protein 2 [KO:K17447]
26052  DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
26084  ARHGEF26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
29119  CTNNA3; catenin alpha 3 [KO:K05691]
3059  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
3611  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
387  RHOA; ras homolog family member A [KO:K04513]
391  RHOG; ras homolog family member G [KO:K07863]
399694  SHC4; SHC adaptor protein 4 [KO:K17449]
4233  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
4735  SEPTIN2; septin 2 [KO:K16942]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
53358  SHC3; SHC adaptor protein 3 [KO:K17448]
55752  SEPTIN11; septin 11 [KO:K16939]
55964  SEPTIN3; septin 3 [KO:K16938]
57180  ACTR3B; actin related protein 3B [KO:K18584]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
5829  PXN; paxillin [KO:K05760]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
60  ACTB; actin beta [KO:K05692]
63916  ELMO2; engulfment and cell motility 2 [KO:K18985]
6464  SHC1; SHC adaptor protein 1 [KO:K06279]
653857  ACTR3C; actin related protein 3C [KO:K18584]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
71  ACTG1; actin gamma 1 [KO:K05692]
7414  VCL; vinculin [KO:K05700]
79658  ARHGAP10; Rho GTPase activating protein 10 [KO:K13736]
79767  ELMO3; engulfment and cell motility 3 [KO:K19241]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
8218  CLTCL1; clathrin heavy chain like 1 [KO:K04646]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
857  CAV1; caveolin 1 [KO:K06278]
858  CAV2; caveolin 2 [KO:K12958]
859  CAV3; caveolin 3 [KO:K12959]
867  CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
8936  WASF1; WASP family member 1 [KO:K05753]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
9564  BCAR1; BCAR1 scaffold protein, Cas family member [KO:K05726]
9844  ELMO1; engulfment and cell motility 1 [KO:K12366]
998  CDC42; cell division cycle 42 [KO:K04393]
999  CDH1; cadherin 1 [KO:K05689]
Reference
PMID:19296488
  Authors
Mostowy S, Cossart P
  Title
Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
  Journal
Cell Motil Cytoskeleton 66:816-23 (2009)
DOI:10.1002/cm.20353
Reference
PMID:16406780
  Authors
Hauck CR, Ohlsen K
  Title
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
  Journal
Curr Opin Microbiol 9:5-11 (2006)
DOI:10.1016/j.mib.2005.12.002
Reference
PMID:17298394
  Authors
Wang B, Li S, Dedhar S, Cleary PP
  Title
Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
  Journal
Cell Microbiol 9:1519-28 (2007)
DOI:10.1111/j.1462-5822.2007.00889.x
Reference
PMID:19185531
  Authors
Matsumoto H, Young GM
  Title
Translocated effectors of Yersinia.
  Journal
Curr Opin Microbiol 12:94-100 (2009)
DOI:10.1016/j.mib.2008.12.005
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:17719540
  Authors
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
  Title
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
  Journal
Cell 130:611-23 (2007)
DOI:10.1016/j.cell.2007.06.043
Related
pathway
hsa04110  Cell cycle
hsa04144  Endocytosis
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04810  Regulation of actin cytoskeleton
KO pathway
ko05100   

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