KEGG   PATHWAY: mcf05160
Entry
mcf05160                    Pathway                                
Name
Hepatitis C - Macaca fascicularis (crab-eating macaque)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcf05160  Hepatitis C
mcf05160

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102127361  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102141434  SCARB1; scavenger receptor class B member 1 isoform X4 [KO:K13885]
102139656  CD81; CD81 antigen isoform X1 [KO:K06508]
102128429  CLDN34; claudin-34 [KO:K06087]
102129287  CLDN8; claudin-8 [KO:K06087]
102129924  CLDN17; claudin-17 [KO:K06087]
102119947  CLDN3; claudin-3 [KO:K06087]
102119565  CLDN4; claudin-4 [KO:K06087]
102117783  CLDN19; claudin-19 isoform X1 [KO:K06087]
102135616  CLDN16; claudin-16 [KO:K06087]
102136275  CLDN1; claudin-1 [KO:K06087]
102126717  CLDN18; claudin-18 [KO:K06087]
102137709  CLDN14; claudin-14 [KO:K06087]
102130343  CLDN20; claudin-20 [KO:K06087]
102131262  putative claudin-24 [KO:K06087]
102131666  CLDN22; claudin-22 [KO:K06087]
102120702  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
102124248  CLDN23; claudin-23 [KO:K06087]
102145576  CLDN7; claudin-7 [KO:K06087]
102122684  CLDN25; putative claudin-25 [KO:K06087]
101925295  CLDN11; claudin-11 [KO:K06087]
102131971  CLDN10; claudin-10 isoform X1 [KO:K06087]
102145924  CLDN2; claudin-2 isoform X1 [KO:K06087]
102140361  CLDN6; claudin-6 [KO:K06087]
102139977  CLDN9; claudin-9 [KO:K06087]
102123763  CLDN12; claudin-12 [KO:K06087]
102126920  OCLN; occludin isoform X1 [KO:K06088]
102131636  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
102132392  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
102132016  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
102143958  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
102141351  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
102132372  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102146717  interferon alpha-17 [KO:K05414]
102140303  interferon alpha-1/13 [KO:K05414]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141744  interferon alpha-1/13 [KO:K05414]
102141352  interferon alpha-1/13-like [KO:K05414]
102143043  IFNA6; interferon alpha-6 [KO:K05414]
102144479  interferon alpha-14 [KO:K05414]
102144833  interferon alpha-4-like [KO:K05414]
102145208  interferon alpha-10 [KO:K05414]
102145962  interferon alpha-17 [KO:K05414]
102115289  interferon alpha-17 [KO:K05414]
102142148  IFNA2; interferon alpha-2 [KO:K05414]
123569038  interferon alpha-17-like [KO:K05414]
102146344  interferon alpha-17-like [KO:K05414]
102147079  interferon alpha-17-like [KO:K05414]
102115670  IFNB1; interferon beta [KO:K05415]
102128291  IFNG; interferon gamma [KO:K04687]
102138517  TLR3; toll-like receptor 3 [KO:K05401]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101926590  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102134351  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101865823  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X4 [KO:K16194] [EC:2.7.11.1]
102124745  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102132060  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
102143994  IFIT1; interferon-induced protein with tetratricopeptide repeats 1 isoform X2 [KO:K14217]
107126407  IFIT1B; interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
101926076  EIF3E; eukaryotic translation initiation factor 3 subunit E isoform X2 [KO:K03250]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102118402  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102123983  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102133020  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102137059  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
102138585  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
102135085  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
101867273  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101865477  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101926525  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X2 [KO:K04354]
102125257  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102142696  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X4 [KO:K04354]
101926197  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
102137928  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101864925  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
101926817  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X4 [KO:K04706] [EC:2.3.2.-]
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102138313  SOS2; son of sevenless homolog 2 [KO:K03099]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101925249  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102115184  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101926442  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101866542  YWHAQ; 14-3-3 protein theta [KO:K16197]
107126481  LOW QUALITY PROTEIN: 14-3-3-like protein GF14 omicron [KO:K16197]
102138573  14-3-3 protein theta-like [KO:K16197]
123573615  14-3-3 protein theta-like [KO:K16197]
101865451  14-3-3 protein epsilon [KO:K06630]
102140425  YWHAE; LOW QUALITY PROTEIN: 14-3-3 protein epsilon [KO:K06630]
102131212  YWHAG; 14-3-3 protein gamma [KO:K16198]
101926535  YWHAH; 14-3-3 protein eta [KO:K16198]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102146984  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102136063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102135998  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102139233  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101925733  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102140874  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102145859  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
102146018  E2F1; transcription factor E2F1 [KO:K17454]
102128093  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
102138138  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101867183  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102142357  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102117102  cytochrome c-like [KO:K08738]
102120205  cytochrome c [KO:K08738]
102125088  cytochrome c-like [KO:K08738]
102136392  cytochrome c-like [KO:K08738]
102127614  cytochrome c-like [KO:K08738]
102141866  cytochrome c-like [KO:K08738]
107127908  cytochrome c-like [KO:K08738]
102120841  cytochrome c-like [KO:K08738]
102123704  cytochrome c-like [KO:K08738]
107130218  cytochrome c-like [KO:K08738]
102137473  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102126830  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
102143196  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
102133330  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102133372  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
102122176  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
102135329  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102127966  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
mcf03320  PPAR signaling pathway
mcf04010  MAPK signaling pathway
mcf04144  Endocytosis
mcf04210  Apoptosis
mcf04514  Cell adhesion molecules
mcf04620  Toll-like receptor signaling pathway
mcf04622  RIG-I-like receptor signaling pathway
mcf04630  JAK-STAT signaling pathway
mcf04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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