KEGG   PATHWAY: mcf05168
Entry
mcf05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Macaca fascicularis (crab-eating macaque)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcf05168  Herpes simplex virus 1 infection
mcf05168

Disease
H00365  Herpes simplex virus infection
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101865193  SRSF1; serine/arginine-rich splicing factor 1 isoform X4 [KO:K12890]
101865347  SRSF7; serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101865792  NXF1; nuclear RNA export factor 1 [KO:K14284]
101865823  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X2 [KO:K16194] [EC:2.7.11.1]
101865975  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101866078  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101866179  IFNGR1; interferon gamma receptor 1 isoform X4 [KO:K05132]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101866531  HCFC1; host cell factor 1 isoform X8 [KO:K14966]
101866608  EIF2B5; translation initiation factor eIF2B subunit epsilon isoform X1 [KO:K03240]
101866679  EIF2B2; translation initiation factor eIF2B subunit beta isoform X2 [KO:K03754]
101866832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101867173  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101925057  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101926185  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
101926282  EIF2B1; translation initiation factor eIF2B subunit alpha isoform X2 [KO:K03239]
101926639  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101926649  EIF2B3; translation initiation factor eIF2B subunit gamma isoform X1 [KO:K03241]
101926826  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101926868  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
102114969  ITGA5; integrin alpha-5 [KO:K06484]
102115289  [KO:K05414]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102115368  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102115670  IFNB1; interferon beta [KO:K05415]
102115793  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
102115798  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
102115891  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102116527  [KO:K06751]
102117040  EIF2B4; translation initiation factor eIF2B subunit delta isoform X2 [KO:K03680]
102117102  [KO:K08738]
102117143  [KO:K06751]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102118430  POU2F2; POU domain, class 2, transcription factor 2 isoform X13 [KO:K09364]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102120132  [KO:K06751]
102120205  [KO:K08738]
102120588  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 isoform X3 [KO:K28004]
102120841  [KO:K08738]
102121336  CALR; calreticulin [KO:K08057]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102121627  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102122138  MAFA-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
102122493  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102122830  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102123548  [KO:K06751]
102123704  [KO:K08738]
102123983  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102124229  TSC1; hamartin isoform X1 [KO:K07206]
102124745  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102124831  TAPBP; tapasin isoform X1 [KO:K08058]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
102125088  [KO:K08738]
102125658  C5; complement C5 isoform X1 [KO:K03994]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102126493  [KO:K15411]
102126830  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102127243  RHEB; GTP-binding protein Rheb [KO:K07208]
102127614  [KO:K08738]
102128291  IFNG; interferon gamma [KO:K04687]
102128371  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102128665  BST2; bone marrow stromal antigen 2 [KO:K06731]
102129572  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
102130835  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102131412  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
102131458  C3; complement C3 [KO:K03990]
102131636  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
102132016  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
102132060  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102132372  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
102132392  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
102132583  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102132662  [KO:K06752]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102133020  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102133037  [KO:K14284]
102133044  [KO:K06752]
102133156  [KO:K14284]
102133276  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
102133300  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
102134829  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102135560  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
102135739  CCL2; C-C motif chemokine 2 [KO:K14624]
102135847  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102135998  TP53; cellular tumor antigen P53 [KO:K04451]
102136392  [KO:K08738]
102136468  [KO:K06752]
102136862  [KO:K06752]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137456  NECTIN2; nectin-2 isoform X1 [KO:K06531]
102137473  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102137481  [KO:K06752]
102137569  ALYREF; THO complex subunit 4 [KO:K12881]
102137780  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102137807  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X2 [KO:K05152]
102138168  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102138212  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102138221  IFNGR2; interferon gamma receptor 2 isoform X2 [KO:K05133]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102138402  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102138497  LTA; lymphotoxin-alpha [KO:K05468]
102138517  TLR3; toll-like receptor 3 [KO:K05401]
102138874  [KO:K06751]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139994  [KO:K06752]
102140002  [KO:K06751]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102140231  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102140303  [KO:K05414]
102140385  [KO:K12890]
102140498  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102140628  TSC2; tuberin isoform X1 [KO:K07207]
102140649  [KO:K06752]
102140886  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141351  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
102141352  [KO:K05414]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102141744  [KO:K05414]
102141835  [KO:K06751]
102141866  [KO:K08738]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142148  [KO:K05414]
102142250  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102142346  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102142357  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142772  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
102143043  [KO:K05414]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102143391  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143958  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
102144039  [KO:K06752]
102144092  CARD9; caspase recruitment domain-containing protein 9 isoform X3 [KO:K12794]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102144414  [KO:K06752]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144479  [KO:K05414]
102144697  NECTIN1; nectin-1 [KO:K06081]
102144774  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102144833  [KO:K05414]
102145084  SRSF8; serine/arginine-rich splicing factor 8 [KO:K12891]
102145208  [KO:K05414]
102145413  [KO:K06752]
102145713  SYK; tyrosine-protein kinase SYK isoform X3 [KO:K05855] [EC:2.7.10.2]
102145785  CFP; properdin [KO:K15412]
102145962  [KO:K05414]
102146068  TLR2; toll-like receptor 2 [KO:K10159]
102146344  [KO:K05414]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102146717  [KO:K05414]
102146918  NXF3; nuclear RNA export factor 3 isoform X2 [KO:K14284]
102146944  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
102147042  SP100; nuclear autoantigen Sp-100 isoform X4 [KO:K15413]
102147079  [KO:K05414]
107127417  [KO:K12891]
107127795  CCL5; C-C motif chemokine 5 [KO:K12499]
107127908  [KO:K08738]
107130218  [KO:K08738]
123569038  [KO:K05414]
123572453  [KO:K15411]
123572909  [KO:K06752]
123572910  [KO:K06752]
135964326  [KO:K06751]
135964343  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
135964355  [KO:K07210]
135967426  [KO:K05414]
135969331  [KO:K14284]
135970091  [KO:K15411]
135970329  [KO:K06751]
135970331  [KO:K06751]
135970333  [KO:K06751]
135970336  [KO:K06751]
135970341  [KO:K06751]
135970343  [KO:K06751]
135970345  [KO:K06751]
135970471  [KO:K06752]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
mcf03040  Spliceosome
mcf03050  Proteasome
mcf04115  p53 signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04610  Complement and coagulation cascades
mcf04612  Antigen processing and presentation
mcf04620  Toll-like receptor signaling pathway
mcf04622  RIG-I-like receptor signaling pathway
mcf04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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