KEGG   PATHWAY: mmu00982
Entry
mmu00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Mus musculus (house mouse)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmu00982  Drug metabolism - cytochrome P450
mmu00982

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
14261  Fmo1; flavin containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
14262  Fmo3; flavin containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
14263  Fmo5; flavin containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
55990  Fmo2; flavin containing monooxygenase 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
226564  Fmo4; flavin containing monooxygenase 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
226565  Fmo6; flavin containing monooxygenase 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
226601  Gm4846; predicted gene 4846 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
240894  Fmo9; flavin containing monooxygenase 9 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
226604  Gm4847; predicted gene 4847 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
14858  Gsta2; glutathione S-transferase, alpha 2 (Yc2) [KO:K00799] [EC:2.5.1.18]
14859  Gsta3; glutathione S-transferase, alpha 3 [KO:K00799] [EC:2.5.1.18]
14860  Gsta4; glutathione S-transferase, alpha 4 [KO:K00799] [EC:2.5.1.18]
14862  Gstm1; glutathione S-transferase, mu 1 [KO:K00799] [EC:2.5.1.18]
14863  Gstm2; glutathione S-transferase, mu 2 [KO:K00799] [EC:2.5.1.18]
14866  Gstm5; glutathione S-transferase, mu 5 [KO:K00799] [EC:2.5.1.18]
14867  Gstm6; glutathione S-transferase, mu 6 [KO:K00799] [EC:2.5.1.18]
14871  Gstt1; glutathione S-transferase, theta 1 [KO:K00799] [EC:2.5.1.18]
14872  Gstt2; glutathione S-transferase, theta 2 [KO:K00799] [EC:2.5.1.18]
14873  Gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
14864  Gstm3; glutathione S-transferase, mu 3 [KO:K00799] [EC:2.5.1.18]
66447  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
14857  Gsta1; glutathione S-transferase, alpha 1 (Ya) [KO:K00799] [EC:2.5.1.18]
56615  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
68214  Gsto2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
68312  Gstm7; glutathione S-transferase, mu 7 [KO:K00799] [EC:2.5.1.18]
14865  Gstm4; glutathione S-transferase, mu 4 [KO:K00799] [EC:2.5.1.18]
211666  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100042295  Gsta13; glutathione S-transferase alpha 13 [KO:K00799] [EC:2.5.1.18]
100042314  Gsta5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
103140  Gstt3; glutathione S-transferase, theta 3 [KO:K00799] [EC:2.5.1.18]
75886  Gstt4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
14870  Gstp1; glutathione S-transferase, pi 1 [KO:K23790] [EC:2.5.1.18]
14869  Gstp2; glutathione S-transferase, pi 2 [KO:K23790] [EC:2.5.1.18]
225884  Gstp3; glutathione S-transferase pi 3 [KO:K23790] [EC:2.5.1.18]
100042625  Gstp-ps; glutathione S-transferase, pi, pseudogene [KO:K23790] [EC:2.5.1.18]
76263  Gstk1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
54486  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
11522  Adh1; alcohol dehydrogenase 1 (class I) [KO:K13951] [EC:1.1.1.1]
11529  Adh7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
26876  Adh4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
11532  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
11670  Aldh3a1; aldehyde dehydrogenase family 3, subfamily A1 [KO:K00129] [EC:1.2.1.5]
67689  Aldh3b1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:1.2.1.5]
621603  Aldh3b2; aldehyde dehydrogenase 3 family, member B2 [KO:K00129] [EC:1.2.1.5]
73458  Aldh3b3; aldehyde dehydrogenase 3 family, member B3 [KO:K00129] [EC:1.2.1.5]
17161  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
109731  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
213043  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
11761  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
71872  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
71724  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
22238  Ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
22236  Ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
94284  Ugt1a6a; UDP glucuronosyltransferase 1 family, polypeptide A6A [KO:K00699] [EC:2.4.1.17]
94215  Ugt2a1; UDP glucuronosyltransferase 2 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
394434  Ugt1a9; UDP glucuronosyltransferase 1 family, polypeptide A9 [KO:K00699] [EC:2.4.1.17]
394430  Ugt1a10; UDP glycosyltransferase 1 family, polypeptide A10 [KO:K00699] [EC:2.4.1.17]
394432  Ugt1a7c; UDP glucuronosyltransferase 1 family, polypeptide A7C [KO:K00699] [EC:2.4.1.17]
394433  Ugt1a5; UDP glucuronosyltransferase 1 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
72094  Ugt2a3; UDP glucuronosyltransferase 2 family, polypeptide A3 [KO:K00699] [EC:2.4.1.17]
552899  Ugt2a2; UDP glucuronosyltransferase 2 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
71773  Ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 [KO:K00699] [EC:2.4.1.17]
394435  Ugt1a6b; UDP glucuronosyltransferase 1 family, polypeptide A6B [KO:K00699] [EC:2.4.1.17]
394436  Ugt1a1; UDP glucuronosyltransferase 1 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
100727  Ugt2b34; UDP glucuronosyltransferase 2 family, polypeptide B34 [KO:K00699] [EC:2.4.1.17]
231396  Ugt2b36; UDP glucuronosyltransferase 2 family, polypeptide B36 [KO:K00699] [EC:2.4.1.17]
100559  Ugt2b38; UDP glucuronosyltransferase 2 family, polypeptide B38 [KO:K00699] [EC:2.4.1.17]
112417  Ugt2b37; UDP glucuronosyltransferase 2 family, polypeptide B37 [KO:K00699] [EC:2.4.1.17]
243085  Ugt2b35; UDP glucuronosyltransferase 2 family, polypeptide B35 [KO:K00699] [EC:2.4.1.17]
613123  Ugt1a8; UDP glucuronosyltransferase 1 family, polypeptide A8 [KO:K00699] [EC:2.4.1.17]
13077  Cyp1a2; cytochrome P450, family 1, subfamily a, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
13106  Cyp2e1; cytochrome P450, family 2, subfamily e, polypeptide 1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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