PATHWAY: mmu04010 Help
Entry
Name
MAPK signaling pathway - Mus musculus (house mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
12286 Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344 ]
12287 Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849 ]
12288 Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850 ]
12289 Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851 ]
12290 Cacna1e; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852 ]
54652 Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853 ]
12291 Cacna1g; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854 ]
58226 Cacna1h; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855 ]
239556 Cacna1i; calcium channel, voltage-dependent, alpha 1I subunit [KO:K04856 ]
12292 Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857 ]
12293 Cacna2d1; calcium channel, voltage-dependent, alpha2/delta subunit 1 [KO:K04858 ]
56808 Cacna2d2; calcium channel, voltage-dependent, alpha 2/delta subunit 2 [KO:K04859 ]
12294 Cacna2d3; calcium channel, voltage-dependent, alpha2/delta subunit 3 [KO:K04860 ]
319734 Cacna2d4; calcium channel, voltage-dependent, alpha 2/delta subunit 4 [KO:K04861 ]
12295 Cacnb1; calcium channel, voltage-dependent, beta 1 subunit [KO:K04862 ]
12296 Cacnb2; calcium channel, voltage-dependent, beta 2 subunit [KO:K04863 ]
12297 Cacnb3; calcium channel, voltage-dependent, beta 3 subunit [KO:K04864 ]
12298 Cacnb4; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865 ]
12299 Cacng1; calcium channel, voltage-dependent, gamma subunit 1 [KO:K04866 ]
12300 Cacng2; calcium channel, voltage-dependent, gamma subunit 2 [KO:K04867 ]
54376 Cacng3; calcium channel, voltage-dependent, gamma subunit 3 [KO:K04868 ]
54377 Cacng4; calcium channel, voltage-dependent, gamma subunit 4 [KO:K04869 ]
140723 Cacng5; calcium channel, voltage-dependent, gamma subunit 5 [KO:K04870 ]
54378 Cacng6; calcium channel, voltage-dependent, gamma subunit 6 [KO:K04871 ]
81904 Cacng7; calcium channel, voltage-dependent, gamma subunit 7 [KO:K04872 ]
81905 Cacng8; calcium channel, voltage-dependent, gamma subunit 8 [KO:K04873 ]
14673 Gna12; guanine nucleotide binding protein, alpha 12 [KO:K04346 ]
14701 Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347 ]
19057 Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
19058 Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268 ]
19059 Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268 ]
19417 Rasgrf1; RAS protein-specific guanine nucleotide-releasing factor 1 [KO:K04349 ]
19418 Rasgrf2; RAS protein-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
19419 Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350 ]
19395 Rasgrp2; RAS, guanyl releasing protein 2 [KO:K12361 ]
76089 Rapgef2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018 ]
21802 Tgfa; transforming growth factor alpha [KO:K08774 ]
18048 Klk1b4; kallikrein 1-related pepidase b4 [KO:K05451 ]
12064 Bdnf; brain derived neurotrophic factor [KO:K04355 ]
18590 Pdgfa; platelet derived growth factor, alpha [KO:K04359 ]
18591 Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386 ]
54635 Pdgfc; platelet-derived growth factor, C polypeptide [KO:K05450 ]
71785 Pdgfd; platelet-derived growth factor, D polypeptide [KO:K05450 ]
12977 Csf1; colony stimulating factor 1 (macrophage) [KO:K05453 ]
14256 Flt3l; FMS-like tyrosine kinase 3 ligand [KO:K05454 ]
22339 Vegfa; vascular endothelial growth factor A [KO:K05448 ]
22340 Vegfb; vascular endothelial growth factor B [KO:K16858 ]
22341 Vegfc; vascular endothelial growth factor C [KO:K05449 ]
14205 Vegfd; vascular endothelial growth factor D [KO:K05449 ]
14573 Gdnf; glial cell line derived neurotrophic factor [KO:K05452 ]
18053 Ngfr; nerve growth factor receptor (TNFR superfamily, member 16) [KO:K02583 ]
18595 Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363 ] [EC:2.7.10.1 ]
18596 Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089 ] [EC:2.7.10.1 ]
14784 Grb2; growth factor receptor bound protein 2 [KO:K04364 ]
20662 Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
20663 Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
20130 Rras; related RAS viral (r-ras) oncogene [KO:K07829 ]
66922 Rras2; related RAS viral (r-ras) oncogene 2 [KO:K07830 ]
56692 Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370 ]
11911 Atf4; activating transcription factor 4 [KO:K04374 ]
13712 Elk1; ELK1, member of ETS oncogene family [KO:K04375 ]
13714 Elk4; ELK4, member of ETS oncogene family [KO:K04376 ]
17762 Mapt; microtubule-associated protein tau [KO:K04380 ]
18783 Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342 ] [EC:3.1.1.4 ]
232889 Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342 ] [EC:3.1.1.4 ]
21803 Tgfb1; transforming growth factor, beta 1 [KO:K13375 ]
21808 Tgfb2; transforming growth factor, beta 2 [KO:K13376 ]
21809 Tgfb3; transforming growth factor, beta 3 [KO:K13377 ]
21937 Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158 ]
16177 Il1r1; interleukin 1 receptor, type I [KO:K04386 ]
16180 Il1rap; interleukin 1 receptor accessory protein [KO:K04723 ]
71609 Tradd; TNFRSF1A-associated via death domain [KO:K03171 ]
13163 Daxx; Fas death domain-associated protein [KO:K02308 ]
17874 Myd88; myeloid differentiation primary response gene 88 [KO:K04729 ]
13197 Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402 ]
17873 Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402 ]
23882 Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402 ]
66513 Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403 ]
68652 Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404 ]
26921 Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407 ] [EC:2.7.11.1 ]
26411 Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408 ] [EC:2.7.11.1 ]
26412 Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414 ] [EC:2.7.11.1 ]
19099 Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434 ]
60597 Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435 ]
30957 Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436 ]
12928 Crk; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438 ]
12929 Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438 ]
102626 Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444 ] [EC:2.7.11.1 ]
18018 Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446 ]
18021 Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333 ]
11909 Atf2; activating transcription factor 2 [KO:K04450 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
13198 Ddit3; DNA-damage inducible transcript 3 [KO:K04452 ]
19042 Ppm1a; protein phosphatase 1A, magnesium dependent, alpha isoform [KO:K04457 ] [EC:3.1.3.16 ]
19043 Ppm1b; protein phosphatase 1B, magnesium dependent, beta isoform [KO:K04461 ] [EC:3.1.3.16 ]
15370 Nr4a1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
18034 Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
19698 Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
mmu04070 Phosphatidylinositol signaling system
KO pathway
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