KEGG   PATHWAY: mmu04020
Entry
mmu04020                    Pathway                                
Name
Calcium signaling pathway - Mus musculus (house mouse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mmu04020  Calcium signaling pathway
mmu04020

Other DBs
GO: 0019722
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
20541  Slc8a1; solute carrier family 8 (sodium/calcium exchanger), member 1 [KO:K05849]
110891  Slc8a2; solute carrier family 8 (sodium/calcium exchanger), member 2 [KO:K05849]
110893  Slc8a3; solute carrier family 8 (sodium/calcium exchanger), member 3 [KO:K05849]
67972  Atp2b1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:7.2.2.10]
320707  Atp2b3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:7.2.2.10]
381290  Atp2b4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:7.2.2.10]
11941  Atp2b2; ATPase, Ca++ transporting, plasma membrane 2 [KO:K05850] [EC:7.2.2.10]
12669  Chrm1; cholinergic receptor, muscarinic 1, CNS [KO:K04129]
12671  Chrm3; cholinergic receptor, muscarinic 3, cardiac [KO:K04131]
213788  Chrm5; cholinergic receptor, muscarinic 5 [KO:K04133]
11540  Adora2a; adenosine A2a receptor [KO:K04266]
11541  Adora2b; adenosine A2b receptor [KO:K04267]
11554  Adrb1; adrenergic receptor, beta 1 [KO:K04141]
11555  Adrb2; adrenergic receptor, beta 2 [KO:K04142]
11556  Adrb3; adrenergic receptor, beta 3 [KO:K04143]
13488  Drd1; dopamine receptor D1 [KO:K04144]
13492  Drd5; dopamine receptor D5 [KO:K05840]
15466  Hrh2; histamine receptor H2 [KO:K04150]
15562  Htr4; 5 hydroxytryptamine (serotonin) receptor 4 [KO:K04160]
15563  Htr5a; 5-hydroxytryptamine (serotonin) receptor 5A [KO:K04161]
15564  Htr5b; 5-hydroxytryptamine (serotonin) receptor 5B [KO:K04161]
15565  Htr6; 5-hydroxytryptamine (serotonin) receptor 6 [KO:K04162]
15566  Htr7; 5-hydroxytryptamine (serotonin) receptor 7 [KO:K04163]
14683  Gnas; GNAS complex locus [KO:K04632]
14680  Gnal; guanine nucleotide binding protein, alpha stimulating, olfactory type [KO:K04633]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18821  Pln; phospholamban [KO:K05852]
66402  Sln; sarcolipin [KO:K22642]
69563  Mrln; myoregulin [KO:K22643]
100039078  Gm2036; predicted gene 2036 [KO:K26467]
67704  1810037I17Rik; RIKEN cDNA 1810037I17 gene [KO:K26467]
68528  Smim6; small integral membrane protein 6 [KO:K26468]
11937  Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:7.2.2.10]
53313  Atp2a3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:7.2.2.10]
11938  Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:7.2.2.10]
15464  Hrc; histidine rich calcium binding protein [KO:K23450]
20866  Stim1; stromal interaction molecule 1 [KO:K16059]
116873  Stim2; stromal interaction molecule 2 [KO:K18196]
109305  Orai1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
269717  Orai2; ORAI calcium release-activated calcium modulator 2 [KO:K16057]
269999  Orai3; ORAI calcium release-activated calcium modulator 3 [KO:K16058]
12288  Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
54652  Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853]
12292  Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
12286  Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
12287  Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
12290  Cacna1e; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
12291  Cacna1g; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
58226  Cacna1h; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
239556  Cacna1i; calcium channel, voltage-dependent, alpha 1I subunit [KO:K04856]
11441  Chrna7; cholinergic receptor, nicotinic, alpha polypeptide 7 [KO:K04809]
14810  Grin1; glutamate receptor, ionotropic, NMDA1 (zeta 1) [KO:K05208]
14811  Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209]
14812  Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210]
14813  Grin2c; glutamate receptor, ionotropic, NMDA2C (epsilon 3) [KO:K05211]
14814  Grin2d; glutamate receptor, ionotropic, NMDA2D (epsilon 4) [KO:K05212]
242443  Grin3a; glutamate receptor ionotropic, NMDA3A [KO:K05213]
170483  Grin3b; glutamate receptor, ionotropic, NMDA3B [KO:K05214]
18436  P2rx1; purinergic receptor P2X, ligand-gated ion channel, 1 [KO:K05215]
231602  P2rx2; purinergic receptor P2X, ligand-gated ion channel, 2 [KO:K05216]
228139  P2rx3; purinergic receptor P2X, ligand-gated ion channel, 3 [KO:K05217]
18438  P2rx4; purinergic receptor P2X, ligand-gated ion channel 4 [KO:K05218]
94045  P2rx5; purinergic receptor P2X, ligand-gated ion channel, 5 [KO:K05219]
18440  P2rx6; purinergic receptor P2X, ligand-gated ion channel, 6 [KO:K05221]
18439  P2rx7; purinergic receptor P2X, ligand-gated ion channel, 7 [KO:K05220]
20190  Ryr1; ryanodine receptor 1, skeletal muscle [KO:K04961]
20191  Ryr2; ryanodine receptor 2, cardiac [KO:K04962]
20192  Ryr3; ryanodine receptor 3 [KO:K04963]
76757  Trdn; triadin [KO:K23449]
12372  Casq1; calsequestrin 1 [KO:K23468]
12373  Casq2; calsequestrin 2 [KO:K23445]
65973  Asph; aspartate-beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
58861  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
70086  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
243764  Chrm2; cholinergic receptor, muscarinic 2, cardiac [KO:K04130]
11549  Adra1a; adrenergic receptor, alpha 1a [KO:K04135]
11548  Adra1b; adrenergic receptor, alpha 1b [KO:K04136]
11550  Adra1d; adrenergic receptor, alpha 1d [KO:K04137]
11607  Agtr1a; angiotensin II receptor, type 1a [KO:K04166]
11608  Agtr1b; angiotensin II receptor, type 1b [KO:K04166]
13617  Ednra; endothelin receptor type A [KO:K04197]
13618  Ednrb; endothelin receptor type B [KO:K04198]
14062  F2r; coagulation factor II thrombin receptor [KO:K03914]
14816  Grm1; glutamate receptor, metabotropic 1 [KO:K04603]
108071  Grm5; glutamate receptor, metabotropic 5 [KO:K04604]
14829  Grpr; gastrin releasing peptide receptor [KO:K04169]
15465  Hrh1; histamine receptor H1 [KO:K04149]
15558  Htr2a; 5-hydroxytryptamine (serotonin) receptor 2A [KO:K04157]
15559  Htr2b; 5-hydroxytryptamine (serotonin) receptor 2B [KO:K04157]
15560  Htr2c; 5-hydroxytryptamine (serotonin) receptor 2C [KO:K04157]
16867  Lhcgr; luteinizing hormone/choriogonadotropin receptor [KO:K04248]
18216  Ntsr1; neurotensin receptor 1 [KO:K04211]
18430  Oxtr; oxytocin receptor [KO:K04229]
54140  Avpr1a; arginine vasopressin receptor 1A [KO:K04226]
26361  Avpr1b; arginine vasopressin receptor 1B [KO:K04227]
57260  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
19204  Ptafr; platelet-activating factor receptor [KO:K04279]
19216  Ptger1; prostaglandin E receptor 1 (subtype EP1) [KO:K04258]
19218  Ptger3; prostaglandin E receptor 3 (subtype EP3) [KO:K04260]
19220  Ptgfr; prostaglandin F receptor [KO:K04262]
12061  Bdkrb1; bradykinin receptor, beta 1 [KO:K03915]
12062  Bdkrb2; bradykinin receptor, beta 2 [KO:K03916]
21336  Tacr1; tachykinin receptor 1 [KO:K04222]
21337  Tacr2; tachykinin receptor 2 [KO:K04223]
21338  Tacr3; tachykinin receptor 3 [KO:K04224]
21390  Tbxa2r; thromboxane A2 receptor [KO:K04264]
22045  Trhr; thyrotropin releasing hormone receptor [KO:K04282]
170732  Trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
12425  Cckar; cholecystokinin A receptor [KO:K04194]
12426  Cckbr; cholecystokinin B receptor [KO:K04195]
12767  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14672  Gna11; guanine nucleotide binding protein, alpha 11 [KO:K04635]
14675  Gna14; guanine nucleotide binding protein, alpha 14 [KO:K04636]
14676  Gna15; guanine nucleotide binding protein, alpha 15 [KO:K04637]
13645  Egf; epidermal growth factor [KO:K04357]
21802  Tgfa; transforming growth factor alpha [KO:K08774]
18590  Pdgfa; platelet derived growth factor, alpha [KO:K04359]
18591  Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386]
54635  Pdgfc; platelet-derived growth factor, C polypeptide [KO:K05450]
71785  Pdgfd; platelet-derived growth factor, D polypeptide [KO:K05450]
14164  Fgf1; fibroblast growth factor 1 [KO:K18496]
14173  Fgf2; fibroblast growth factor 2 [KO:K18497]
14174  Fgf3; fibroblast growth factor 3 [KO:K04358]
14175  Fgf4; fibroblast growth factor 4 [KO:K04358]
14176  Fgf5; fibroblast growth factor 5 [KO:K04358]
14178  Fgf7; fibroblast growth factor 7 [KO:K04358]
14179  Fgf8; fibroblast growth factor 8 [KO:K04358]
14180  Fgf9; fibroblast growth factor 9 [KO:K04358]
14165  Fgf10; fibroblast growth factor 10 [KO:K04358]
80903  Fgf16; fibroblast growth factor 16 [KO:K04358]
14171  Fgf17; fibroblast growth factor 17 [KO:K04358]
14172  Fgf18; fibroblast growth factor 18 [KO:K04358]
80857  Fgf20; fibroblast growth factor 20 [KO:K04358]
67112  Fgf22; fibroblast growth factor 22 [KO:K04358]
14177  Fgf6; fibroblast growth factor 6 [KO:K04358]
14170  Fgf15; fibroblast growth factor 15 [KO:K22603]
56636  Fgf21; fibroblast growth factor 21 [KO:K22429]
64654  Fgf23; fibroblast growth factor 23 [KO:K22428]
22339  Vegfa; vascular endothelial growth factor A [KO:K05448]
22340  Vegfb; vascular endothelial growth factor B [KO:K16858]
22341  Vegfc; vascular endothelial growth factor C [KO:K05449]
14205  Vegfd; vascular endothelial growth factor D [KO:K05449]
18048  Klk1b4; kallikrein 1-related pepidase b4 [KO:K05451]
18049  Ngf; nerve growth factor [KO:K02582]
15234  Hgf; hepatocyte growth factor [KO:K05460]
15235  Mst1; macrophage stimulating 1 (hepatocyte growth factor-like) [KO:K23441]
14573  Gdnf; glial cell line derived neurotrophic factor [KO:K05452]
13649  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
13866  Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
13867  Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
13869  Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
18595  Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
18596  Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
14182  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
14183  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
14184  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
14186  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
14254  Flt1; FMS-like tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
14257  Flt4; FMS-like tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
16542  Kdr; kinase insert domain protein receptor [KO:K05098] [EC:2.7.10.1]
18211  Ntrk1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
18212  Ntrk2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
18213  Ntrk3; neurotrophic tyrosine kinase, receptor, type 3 [KO:K05101] [EC:2.7.10.1]
17295  Met; met proto-oncogene [KO:K05099] [EC:2.7.10.1]
19882  Mst1r; macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [KO:K05100] [EC:2.7.10.1]
19713  Ret; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
18799  Plcd1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
72469  Plcd3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
18802  Plcd4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18803  Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
234779  Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
74055  Plce1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
114875  Plcz1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
12494  Cd38; CD38 antigen [KO:K01242] [EC:3.2.2.6 2.4.99.20]
252972  Tpcn1; two pore channel 1 [KO:K16896]
233979  Tpcn2; two pore segment channel 2 [KO:K14077]
94178  Mcoln1; mucolipin 1 [KO:K04992]
68279  Mcoln2; mucolipin 2 [KO:K04993]
171166  Mcoln3; mucolipin 3 [KO:K04994]
56632  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
20698  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
215999  Mcu; mitochondrial calcium uniporter [KO:K20858]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
105675  Ppif; peptidylprolyl isomerase F (cyclophilin F) [KO:K09565] [EC:5.2.1.8]
21924  Tnnc1; troponin C, cardiac/slow skeletal [KO:K05865]
21925  Tnnc2; troponin C2, fast [KO:K12042]
12313  Calm1; calmodulin 1 [KO:K02183]
80796  Calm4; calmodulin 4 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
70405  Calml3; calmodulin-like 3 [KO:K02183]
494124  Calm5; calmodulin 5 [KO:K02183]
75600  Calml4; calmodulin-like 4 [KO:K02183]
18682  Phkg1; phosphorylase kinase gamma 1 [KO:K00871] [EC:2.7.11.19]
68961  Phkg2; phosphorylase kinase, gamma 2 (testis) [KO:K00871] [EC:2.7.11.19]
110094  Phka2; phosphorylase kinase alpha 2 [KO:K07190]
18679  Phka1; phosphorylase kinase alpha 1 [KO:K07190]
102093  Phkb; phosphorylase kinase beta [KO:K07190]
107589  Mylk; myosin, light polypeptide kinase [KO:K00907] [EC:2.7.11.18]
213435  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
228785  Mylk2; myosin, light polypeptide kinase 2, skeletal muscle [KO:K00907] [EC:2.7.11.18]
238564  Mylk4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
215303  Camk1g; calcium/calmodulin-dependent protein kinase I gamma [KO:K08794] [EC:2.7.11.17]
52163  Camk1; calcium/calmodulin-dependent protein kinase I [KO:K08794] [EC:2.7.11.17]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12326  Camk4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
21425  Tfeb; transcription factor EB [KO:K15590]
18018  Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
73181  Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
18127  Nos3; nitric oxide synthase 3, endothelial cell [KO:K13242] [EC:1.14.13.39]
18573  Pde1a; phosphodiesterase 1A, calmodulin-dependent [KO:K13755] [EC:3.1.4.17]
18574  Pde1b; phosphodiesterase 1B, Ca2+-calmodulin dependent [KO:K13755] [EC:3.1.4.17]
18575  Pde1c; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
19229  Ptk2b; PTK2 protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
320404  Itpkb; inositol 1,4,5-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
228550  Itpka; inositol 1,4,5-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
233011  Itpkc; inositol 1,4,5-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mmu04010  MAPK signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04210  Apoptosis
mmu04720  Long-term potentiation
mmu04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system