Entry Name Viral protein interaction with cytokine and cytokine receptor - Mus musculus (house mouse)
Description Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map mmu04061 Viral protein interaction with cytokine and cytokine receptor
Ortholog table Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 20301 Ccl27a; C-C motif chemokine ligand 27A [KO:K16598 ]
18829 Ccl21a; C-C motif chemokine ligand 21 (serine) [KO:K16062 ]
14825 Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505 ]
20310 Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505 ]
20311 Cxcl5; C-X-C motif chemokine ligand 5 [KO:K05506 ]
17329 Cxcl9; C-X-C motif chemokine ligand 9 [KO:K05416 ]
15945 Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
56066 Cxcl11; chemokine (C-X-C motif) ligand 11 [KO:K12672 ]
55985 Cxcl13; C-X-C motif chemokine ligand 13 [KO:K10032 ]
20315 Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031 ]
57266 Cxcl14; C-X-C motif chemokine ligand 14 [KO:K10033 ]
20312 Cx3cl1; C-X3-C motif chemokine ligand 1 [KO:K05508 ]
50930 Tnfsf14; tumor necrosis factor (ligand) superfamily, member 14 [KO:K05477 ]
22035 Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721 ]
12977 Csf1; colony stimulating factor 1 (macrophage) [KO:K05453 ]
12770 Ccr1l1; C-C motif chemokine receptor 1 like 1 [KO:K04176 ]
12777 Ccr10; C-C motif chemokine receptor 10 [KO:K04185 ]
12765 Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050 ]
12766 Cxcr3; C-X-C motif chemokine receptor 3 [KO:K04188 ]
12145 Cxcr5; C-X-C motif chemokine receptor 5 [KO:K04190 ]
12767 Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189 ]
13051 Cx3cr1; C-X3-C motif chemokine receptor 1 [KO:K04192 ]
16154 Il10ra; interleukin 10 receptor, alpha [KO:K05134 ]
16155 Il10rb; interleukin 10 receptor, beta [KO:K05135 ]
16195 Il6st; interleukin 6 signal transducer [KO:K05060 ]
16184 Il2ra; interleukin 2 receptor, alpha chain [KO:K05068 ]
16185 Il2rb; interleukin 2 receptor, beta chain [KO:K05069 ]
16186 Il2rg; interleukin 2 receptor, gamma chain [KO:K05070 ]
16174 Il18rap; interleukin 18 receptor accessory protein [KO:K05174 ]
230828 Il22ra1; interleukin 22 receptor, alpha 1 [KO:K05138 ]
21937 Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158 ]
21938 Tnfrsf1b; tumor necrosis factor receptor superfamily, member 1b [KO:K05141 ]
230979 Tnfrsf14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [KO:K05152 ]
21933 Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722 ]
Reference Authors Alcami A
Title Viral mimicry of cytokines, chemokines and their receptors.
Journal Reference Authors Pontejo SM, Murphy PM
Title Chemokines encoded by herpesviruses.
Journal Reference Authors de Munnik SM, Smit MJ, Leurs R, Vischer HF
Title Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
Journal Reference Authors Vischer HF, Siderius M, Leurs R, Smit MJ
Title Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Journal Reference Authors Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
Title Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
Journal Reference Authors Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
Title Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
Journal Reference Authors Damon I, Murphy PM, Moss B
Title Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
Journal Reference Authors Dewin DR, Catusse J, Gompels UA
Title Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
Journal Reference Authors Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
Title Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Journal Reference Authors Wang D, Bresnahan W, Shenk T
Title Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
Journal Reference Authors Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
Title Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
Journal Reference Authors Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
Title A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
Journal Reference Authors Tadagaki K, Nakano K, Yamanishi K
Title Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
Journal Reference Authors Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
Title Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Journal Reference Authors Najarro P, Lee HJ, Fox J, Pease J, Smith GL
Title Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Journal Reference Authors Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
Title Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
Journal Reference Authors Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
Title Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
Journal Reference Authors Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
Title The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
Journal J Immunol 158:604-13 (1997)
Reference Authors Yoon SI, Jones BC, Logsdon NJ, Walter MR
Title Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Journal Reference Authors Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
Title Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Journal Reference Authors Chang WL, Baumgarth N, Yu D, Barry PA
Title Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
Journal Reference Authors Li H, Wang H, Nicholas J
Title Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Journal Reference Authors Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
Title HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Journal Reference Authors Xiang Y, Moss B
Title IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
Journal Reference Authors Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
Title A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
Journal Reference Authors Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
Title The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Journal Reference Authors Snow AL, Martinez OM
Title Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Journal Reference Authors Shim AH, Chang RA, Chen X, Longnecker R, He X
Title Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Journal Reference Authors Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
Title The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
Journal Reference Authors Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
Title A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Journal Reference Authors Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
Title Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
Journal Reference Authors Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
Title Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
Journal KO pathway LinkDB All DBs
