KEGG   PATHWAY: mmu04114
Entry
mmu04114                    Pathway                                
Name
Oocyte meiosis - Mus musculus (house mouse)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class
Cellular Processes; Cell growth and death
Pathway map
mmu04114  Oocyte meiosis
mmu04114

Other DBs
GO: 0051321
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100039786  Gm2423; predicted gene 2423 [KO:K16197]
103583  Fbxw11; F-box and WD-40 domain protein 11 [KO:K03362]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
105988  Espl1; extra spindle pole bodies 1, separase [KO:K02365] [EC:3.4.22.49]
107995  Cdc20; cell division cycle 20 [KO:K03363]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
110651  Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
114875  Plcz1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11835  Ar; androgen receptor [KO:K08557]
12234  Btrc; beta-transducin repeat containing protein [KO:K03362]
12235  Bub1; BUB1, mitotic checkpoint serine/threonine kinase [KO:K02178] [EC:2.7.11.1]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12442  Ccnb2; cyclin B2 [KO:K21770]
12447  Ccne1; cyclin E1 [KO:K06626]
12448  Ccne2; cyclin E2 [KO:K06626]
12532  Cdc25c; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
12534  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
12566  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
12877  Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602]
13006  Smc3; structural maintenance of chromosomes 3 [KO:K06669]
140557  Smc1b; structural maintenance of chromosomes 1B [KO:K06636]
16000  Igf1; insulin-like growth factor 1 [KO:K05459]
16001  Igf1r; insulin-like growth factor I receptor [KO:K05087] [EC:2.7.10.1]
16333  Ins1; insulin I [KO:K04526]
16334  Ins2; insulin II [KO:K04526]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
17120  Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679]
17222  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
17451  Mos; Moloney sarcoma oncogene [KO:K04367] [EC:2.7.11.1]
18667  Pgr; progesterone receptor [KO:K08556]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18817  Plk1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
19045  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
19046  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
19047  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
19052  Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382] [EC:3.1.3.16]
19053  Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382] [EC:3.1.3.16]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
20111  Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
20112  Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
20874  Slk; STE20-like kinase [KO:K08836] [EC:2.7.11.1]
20878  Aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
208922  Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
21402  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
217232  Cdc27; cell division cycle 27 [KO:K03350]
21770  Ppp2r5d; protein phosphatase 2, regulatory subunit B', delta [KO:K11584]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
225849  Ppp2r5b; protein phosphatase 2, regulatory subunit B', beta [KO:K11584]
22627  Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630]
22628  Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [KO:K16198]
22629  Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [KO:K16198]
22630  Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
22631  Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [KO:K16197]
226849  Ppp2r5a; protein phosphatase 2, regulatory subunit B', alpha [KO:K11584]
231207  Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602]
24061  Smc1a; structural maintenance of chromosomes 1A [KO:K06636]
241634  Spdye4c; speedy/RINGO cell cycle regulator family, member E4C [KO:K08694]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
268697  Ccnb1; cyclin B1 [KO:K05868]
268930  Pkmyt1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1]
26931  Ppp2r5c; protein phosphatase 2, regulatory subunit B', gamma [KO:K11584]
26932  Ppp2r5e; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
26965  Cul1; cullin 1 [KO:K03347]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
30939  Pttg1; pituitary tumor-transforming gene 1 [KO:K06635]
330228  Spdye4b; speedy/RINGO cell cycle regulator family, member E4B [KO:K08694]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
434175  Ccnb1-ps; cyclin B1, pseudogene [KO:K05868]
434233  Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B [KO:K06269] [EC:3.1.3.16]
494124  Calm5; calmodulin 5 [KO:K02183]
50878  Stag3; STAG3 cohesin complex component [KO:K13055]
51792  Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
52206  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
52563  Cdc23; CDC23 cell division cycle 23 [KO:K03355]
52717  Anapc16; anaphase promoting complex subunit 16 [KO:K25229]
54401  Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [KO:K16197]
56150  Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
56317  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
56438  Rbx1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
56739  Rec8; REC8 meiotic recombination protein [KO:K13054]
59008  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
66156  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  Cdc26; cell division cycle 26 [KO:K03359]
67071  Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
67141  Fbxo5; F-box protein 5 [KO:K10292]
67579  Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602]
68999  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
69010  Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
69957  Cdc16; CDC16 cell division cycle 16 [KO:K03353]
70405  Calml3; calmodulin-like 3 [KO:K02183]
70891  Spdya; speedy/RINGO cell cycle regulator family, member A [KO:K08694]
71890  Mad2l2; MAD2 mitotic arrest deficient-like 2 [KO:K13728]
72415  Sgo1; shugoshin 1 [KO:K11580]
73699  Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
74673  Spdye4a; speedy/RINGO cell cycle regulator family, member E4A [KO:K08694]
75430  Anapc15; anaphase promoting complex C subunit 15 [KO:K25228]
75600  Calml4; calmodulin-like 4 [KO:K02183]
78803  Fbxo43; F-box protein 43 [KO:K10318]
80796  Calm4; calmodulin 4 [KO:K02183]
99152  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
Compound
C00076  Calcium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16760654
  Authors
Haccard O, Jessus C
  Title
Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
  Journal
Cell Cycle 5:1152-9 (2006)
DOI:10.4161/cc.5.11.2800
Reference
PMID:15182704
  Authors
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
  Title
Aurora A, meiosis and mitosis.
  Journal
Biol Cell 96:215-29 (2004)
DOI:10.1016/j.biolcel.2003.09.008
Reference
PMID:15136768
  Authors
Perdiguero E, Nebreda AR
  Title
Regulation of Cdc25C activity during the meiotic G2/M transition.
  Journal
Cell Cycle 3:733-7 (2004)
DOI:10.4161/cc.3.6.906
Reference
PMID:17480229
  Authors
Perry JA, Kornbluth S
  Title
Cdc25 and Wee1: analogous opposites?
  Journal
Cell Div 2:12 (2007)
DOI:10.1186/1747-1028-2-12
Reference
PMID:15182701
  Authors
Jessus C, Ozon R
  Title
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
  Journal
Biol Cell 96:187-92 (2004)
DOI:10.1016/j.biolcel.2003.12.007
Reference
PMID:16518630
  Authors
Revenkova E, Jessberger R
  Title
Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
  Journal
Chromosoma 115:235-40 (2006)
DOI:10.1007/s00412-006-0060-x
Reference
PMID:18631137
  Authors
Belloc E, Pique M, Mendez R
  Title
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
  Journal
Biochem Soc Trans 36:665-70 (2008)
DOI:10.1042/BST0360665
Reference
PMID:18598214
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
PMID:18550795
  Authors
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
  Title
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  Journal
Mol Biol Cell 19:3536-43 (2008)
DOI:10.1091/mbc.E08-04-0417
Reference
PMID:18946022
  Authors
Wu JQ, Kornbluth S
  Title
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
  Journal
J Cell Sci 121:3509-14 (2008)
DOI:10.1242/jcs.036855
Reference
PMID:16554437
  Authors
Schmidt A, Rauh NR, Nigg EA, Mayer TU
  Title
Cytostatic factor: an activity that puts the cell cycle on hold.
  Journal
J Cell Sci 119:1213-8 (2006)
DOI:10.1242/jcs.02919
Reference
PMID:18096427
  Authors
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
  Title
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
  Journal
Mutat Res 651:14-29 (2008)
DOI:10.1016/j.mrgentox.2007.10.015
Reference
PMID:18311174
  Authors
Perry AC, Verlhac MH
  Title
Second meiotic arrest and exit in frogs and mice.
  Journal
EMBO Rep 9:246-51 (2008)
DOI:10.1038/embor.2008.22
Reference
PMID:14691134
  Authors
Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
  Title
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
  Journal
J Cell Biol 163:1231-42 (2003)
DOI:10.1083/jcb.200306153
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Related
pathway
mmu04010  MAPK signaling pathway
mmu04120  Ubiquitin mediated proteolysis
mmu04914  Progesterone-mediated oocyte maturation
KO pathway
ko04114   

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