Entry
Name
TGF-beta signaling pathway - Mus musculus (house mouse)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
17965 Nbl1; NBL1, DAN family BMP antagonist [KO:K19558 ]
23892 Grem1; gremlin 1, DAN family BMP antagonist [KO:K23318 ]
23893 Grem2; gremlin 2, DAN family BMP antagonist [KO:K23318 ]
13590 Lefty1; left right determination factor 1 [KO:K04668 ]
320202 Lefty2; left-right determination factor 2 [KO:K04668 ]
71775 Inhca; inhibitor of carbonic anhydrase [KO:K14736 ]
14563 Gdf5; growth differentiation factor 5 [KO:K04664 ]
207596 Thsd4; thrombospondin, type I, domain containing 4 [KO:K23377 ]
268977 Ltbp1; latent transforming growth factor beta binding protein 1 [KO:K19559 ]
21803 Tgfb1; transforming growth factor, beta 1 [KO:K13375 ]
21808 Tgfb2; transforming growth factor, beta 2 [KO:K13376 ]
21809 Tgfb3; transforming growth factor, beta 3 [KO:K13377 ]
244058 Rgma; repulsive guidance molecule family member A [KO:K23096 ]
68799 Rgmb; repulsive guidance molecule family member B [KO:K06847 ]
434215 Lrrc32; leucine rich repeat containing 32 [KO:K26316 ]
224109 Nrros; negative regulator of reactive oxygen species [KO:K26317 ]
209268 Igsf1; immunoglobulin superfamily, member 1 [KO:K26168 ]
68010 Bambi; BMP and activin membrane-bound inhibitor [KO:K10162 ]
218441 Zfyve16; zinc finger, FYVE domain containing 16 [KO:K04679 ]
230597 Zfyve9; zinc finger, FYVE domain containing 9 [KO:K04679 ]
21402 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
67653 4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513 ]
51792 Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456 ]
73699 Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456 ]
19052 Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
19053 Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
66438 Hamp2; hepcidin antimicrobial peptide 2 [KO:K23106 ]
15901 Id1; inhibitor of DNA binding 1, HLH protein [KO:K04680 ]
19650 Rbl1; RB transcriptional corepressor like 1 [KO:K04681 ]
20683 Sp1; trans-acting transcription factor 1 [KO:K04684 ]
20481 Ski; ski sarcoma viral oncogene homolog (avian) [KO:K26503 ]
20466 Sin3a; transcriptional regulator, SIN3A (yeast) [KO:K11644 ]
20185 Ncor1; nuclear receptor co-repressor 1 [KO:K04650 ]
21815 Tgif1; TGFB-induced factor homeobox 1 [KO:K19383 ]
12579 Cdkn2b; cyclin dependent kinase inhibitor 2B [KO:K04685 ]
18741 Pitx2; paired-like homeodomain transcription factor 2 [KO:K04686 ]
Compound
Reference
Authors
Shi Y, Massague J.
Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Journal
Reference
Authors
Derynck R, Zhang YE.
Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Journal
Reference
Authors
Massague J.
Title
How cells read TGF-beta signals.
Journal
Reference
Authors
Siegel PM, Massague J.
Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
Journal
Reference
Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
Title
The bone morphogenetic protein system in mammalian reproduction.
Journal
Reference
Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
Journal
Reference
Authors
Gumienny TL, Padgett RW.
Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
Journal
Reference
Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
Title
Establishment of vertebrate left-right asymmetry.
Journal
Reference
Authors
Chang H, Brown CW, Matzuk MM.
Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
Journal
Reference
Authors
Morita K, Chow KL, Ueno N.
Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
Journal
Development 126:1337-47 (1999)
Reference
Authors
Krishna S, Maduzia LL, Padgett RW.
Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
Journal
Development 126:251-60 (1999)
Reference
Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
Journal
Reference
Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
Journal
Reference
Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
Journal
Reference
Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
Journal
Reference
Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
Journal
Reference
Authors
Anderson GJ, Frazer DM
Title
Iron metabolism meets signal transduction.
Journal
Reference
Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Journal
Reference
Authors
Ganz T, Nemeth E
Title
Iron homeostasis in host defence and inflammation.
Journal
Reference
Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
Journal
Reference
Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
Title
DRAGON, a bone morphogenetic protein co-receptor.
Journal
Reference
Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
Title
On Iron Metabolism and Its Regulation.
Journal
Reference
Authors
Ikushima H, Miyazono K
Title
TGFbeta signalling: a complex web in cancer progression.
Journal
Related pathway
KO pathway
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