KEGG   PATHWAY: mmu04621
Entry
mmu04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Mus musculus (house mouse)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
mmu04621  NOD-like receptor signaling pathway
mmu04621

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
107607  Nod1; nucleotide-binding oligomerization domain containing 1 [KO:K08727]
192656  Ripk2; receptor (TNFRSF)-interacting serine-threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
18036  Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
16176  Il1b; interleukin 1 beta [KO:K04519]
16173  Il18; interleukin 18 [KO:K05482]
16193  Il6; interleukin 6 [KO:K05405]
21926  Tnf; tumor necrosis factor [KO:K03156]
14825  Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505]
20310  Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505]
330122  Cxcl3; C-X-C motif chemokine ligand 3 [KO:K05505]
20296  Ccl2; C-C motif chemokine ligand 2 [KO:K14624]
20293  Ccl12; C-C motif chemokine ligand 12 [KO:K14624]
20304  Ccl5; C-C motif chemokine ligand 5 [KO:K12499]
12796  Camp; cathelicidin antimicrobial peptide [KO:K13916]
13237  Defa3; defensin, alpha, 3 [KO:K05230]
13239  Defa5; defensin, alpha, 5 [KO:K05230]
13240  Defa6; defensin, alpha, 6 [KO:K05230]
382059  Defa22; defensin, alpha, 22 [KO:K05230]
66298  Defa21; defensin, alpha, 21 [KO:K05230]
68009  Defa20; defensin, alpha, 20 [KO:K05230]
13216  Defa1; defensin, alpha 1 [KO:K05230]
13218  Defa29; defensin, alpha, 29 [KO:K05230]
13219  Defa-rs10; defensin, alpha, related sequence 10 [KO:K05230]
13221  Defa-rs12; defensin, alpha, related sequence 12 [KO:K05230]
13222  Defa-rs2; defensin, alpha, related sequence 2 [KO:K05230]
13226  Defa31; defensin, alpha, 31 [KO:K05230]
382000  Defa39; defensin, alpha, 39 [KO:K05230]
497114  Defa23; defensin, alpha, 23 [KO:K05230]
13238  Defa4; defensin, alpha, 4 [KO:K05230]
100294660  Defa2; defensin, alpha, 2 [KO:K05230]
23855  Defa17; defensin, alpha, 17 [KO:K05230]
100041890  Defa32; defensin, alpha, 32 [KO:K05230]
100505096  Defa33; defensin, alpha, 33 [KO:K05230]
100041811  Defa27; defensin, alpha, 27 [KO:K05230]
626708  Defa26; defensin, alpha, 26 [KO:K05230]
100041895  Defa37; defensin, alpha, 37 [KO:K05230]
100041759  Defa41; defensin, alpha, 41 [KO:K05230]
100041787  Defa40; defensin, alpha, 40 [KO:K05230]
100038927  Defa30; defensin, alpha, 30 [KO:K05230]
100041688  Defa35; defensin, alpha, 35 [KO:K05230]
100041952  Defa34; defensin, alpha, 34 [KO:K05230]
13236  Defa25; defensin, alpha, 25 [KO:K05230]
100862126  Defa36; defensin, alpha, 36 [KO:K05230]
503491  Defa24; defensin, alpha, 24 [KO:K05230]
626682  Defa28; defensin, alpha, 28 [KO:K05230]
665927  Defa42; defensin, alpha, 42 [KO:K05230]
634825  Defa38; defensin, alpha, 38 [KO:K05230]
100503970  cDNA sequence AY761185 [KO:K05230]
665956  Defa43; defensin, alpha, 43 [KO:K05230]
13223  Defa-rs4; defensin, alpha,, related sequence 4 [KO:K05230]
56519  Defb4; defensin beta 4 [KO:K21100]
116746  Defb6; defensin beta 6 [KO:K21100]
27358  Defb3; defensin beta 3 [KO:K21100]
244332  Defb14; defensin beta 14 [KO:K23126]
257632  Nod2; nucleotide-binding oligomerization domain containing 2 [KO:K10165]
26409  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
66513  Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
68652  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
66724  Tab3; TGF-beta activated kinase 1/MAP3K7 binding protein 3 [KO:K12793]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
16476  Jun; jun proto-oncogene [KO:K04448]
77040  Atg16l1; autophagy related 16 like 1 [KO:K17890]
11793  Atg5; autophagy related 5 [KO:K08339]
67526  Atg12; autophagy related 12 [KO:K08336]
57436  Gabarapl1; GABA type A receptor associated protein like 1 [KO:K08341]
56486  Gabarap; gamma-aminobutyric acid receptor associated protein [KO:K08341]
93739  Gabarapl2; GABA type A receptor associated protein like 2 [KO:K08341]
66734  Map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435]
67443  Map1lc3b; microtubule-associated protein 1 light chain 3 beta [KO:K10435]
67955  Sugt1; SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) [KO:K12795]
106025  Sharpin; SHANK-associated RH domain interacting protein [KO:K20894]
24105  Rbck1; RanBP-type and C3HC4-type zinc finger containing 1 [KO:K10630] [EC:2.3.2.31]
268749  Rnf31; ring finger protein 31 [KO:K11974] [EC:2.3.2.31]
11798  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
239319  Card6; caspase recruitment domain family, member 6 [KO:K12797]
22051  Trip6; thyroid hormone receptor interactor 6 [KO:K12792]
59079  Erbin; Erbb2 interacting protein [KO:K12796]
11797  Birc2; baculoviral IAP repeat-containing 2 [KO:K16060]
11796  Birc3; baculoviral IAP repeat-containing 3 [KO:K16060]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
22033  Traf5; TNF receptor-associated factor 5 [KO:K09849]
22034  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
332579  Card9; caspase recruitment domain family, member 9 [KO:K12794]
21929  Tnfaip3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
228607  Mavs; mitochondrial antiviral signaling protein [KO:K12648]
22031  Traf3; TNF receptor-associated factor 3 [KO:K03174]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
56489  Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
21353  Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
54123  Irf7; interferon regulatory factor 7 [KO:K09447]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
230396  Ifna13; interferon alpha 13 [KO:K05414]
404549  Ifna14; interferon alpha 14 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
242517  Ifna15; interferon alpha 15 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
15977  Ifnb1; interferon beta 1, fibroblast [KO:K05415]
270151  Nlrx1; NLR family member X1 [KO:K12653]
71914  Antxr2; anthrax toxin receptor 2 [KO:K20909]
69538  Antxr1; anthrax toxin receptor 1 [KO:K20909]
195046  Nlrp1a; NLR family, pyrin domain containing 1A [KO:K12798]
637515  Nlrp1b; NLR family, pyrin domain containing 1B [KO:K12798]
66824  Pycard; PYD and CARD domain containing [KO:K12799]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
13030  Ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
216799  Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800]
55991  Panx1; pannexin 1 [KO:K03443]
18439  P2rx7; purinergic receptor P2X, ligand-gated ion channel, 7 [KO:K05220]
28240  Trpm2; transient receptor potential cation channel, subfamily M, member 2 [KO:K04977] [EC:3.6.1.13]
58800  Trpm7; transient receptor potential cation channel, subfamily M, member 7 [KO:K04982] [EC:2.7.11.1]
22368  Trpv2; transient receptor potential cation channel, subfamily V, member 2 [KO:K04971]
12374  Casr; calcium-sensing receptor [KO:K04612]
210198  Gprc6a; G protein-coupled receptor, family C, group 6, member A [KO:K04622]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
215999  Mcu; mitochondrial calcium uniporter [KO:K20858]
246730  Oas1a; 2'-5' oligoadenylate synthetase 1A [KO:K14216] [EC:2.7.7.84]
246728  Oas2; 2'-5' oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
246727  Oas3; 2'-5' oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
23961  Oas1b; 2'-5' oligoadenylate synthetase 1B [KO:K14216] [EC:2.7.7.84]
23960  Oas1g; 2'-5' oligoadenylate synthetase 1G [KO:K14216] [EC:2.7.7.84]
24014  Rnasel; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [KO:K01165]
216877  Dhx33; DEAH-box helicase 33 [KO:K17820] [EC:5.6.2.6]
67414  Mfn1; mitofusin 1 [KO:K21356] [EC:3.6.5.-]
170731  Mfn2; mitofusin 2 [KO:K06030] [EC:3.6.5.-]
19766  Ripk1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
56532  Ripk3; receptor-interacting serine-threonine kinase 3 [KO:K08847] [EC:2.7.11.1]
74006  Dnm1l; dynamin 1-like [KO:K17065] [EC:3.6.5.5]
59027  Nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
13057  Cyba; cytochrome b-245, alpha polypeptide [KO:K08009]
56338  Txnip; thioredoxin interacting protein [KO:K20910]
22166  Txn1; thioredoxin 1 [KO:K03671]
56551  Txn2; thioredoxin 2 [KO:K03671]
59125  Nek7; NIMA (never in mitosis gene a)-related expressed kinase 7 [KO:K20876] [EC:2.7.11.34]
210766  Brcc3; BRCA1/BRCA2-containing complex, subunit 3 [KO:K11864] [EC:3.4.19.-]
368203  Brcc3dc; BRCA1/BRCA2-containing complex, subunit 3, domain containing [KO:K11864] [EC:3.4.19.-]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
106512  Gpsm3; G-protein signalling modulator 3 (AGS3-like, C. elegans) [KO:K15838]
15944  Irgm1; immunity-related GTPase family M member 1 [KO:K14139] [EC:3.6.5.-]
54396  Irgm2; immunity-related GTPase family M member 2 [KO:K14139] [EC:3.6.5.-]
54483  Mefv; Mediterranean fever [KO:K12803]
19200  Pstpip1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
14082  Fadd; Fas associated via death domain [KO:K02373]
12364  Casp12; caspase 12 [KO:K04741] [EC:3.4.22.-]
101613  Nlrp6; NLR family, pyrin domain containing 6 [KO:K20863]
378425  Nlrp12; NLR family, pyrin domain containing 12 [KO:K20865]
17940  Naip1; NLR family, apoptosis inhibitory protein 1 [KO:K12807]
17951  Naip5; NLR family, apoptosis inhibitory protein 5 [KO:K12807]
17952  Naip6; NLR family, apoptosis inhibitory protein 6 [KO:K12807]
53880  Naip7; NLR family, apoptosis inhibitory protein 7 [KO:K12807]
17948  Naip2; NLR family, apoptosis inhibitory protein 2 [KO:K12807]
268973  Nlrc4; NLR family, CARD domain containing 4 [KO:K12805]
18753  Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
14469  Gbp2; guanylate binding protein 2 [KO:K20897]
14468  Gbp2b; guanylate binding protein 2b [KO:K20897]
229898  Gbp5; guanylate binding protein 5 [KO:K20898]
383619  Aim2; absent in melanoma 2 [KO:K12966]
15951  Ifi204; interferon activated gene 204 [KO:K20914]
27223  Trp53bp1; transformation related protein 53 binding protein 1 [KO:K20915]
11848  Rhoa; ras homolog family member A [KO:K04513]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
320795  Pkn1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
109333  Pkn2; protein kinase N2 [KO:K23691] [EC:2.7.11.13]
22627  Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630]
55932  Gbp3; guanylate binding protein 3 [KO:K20899]
229900  Gbp7; guanylate binding protein 7 [KO:K20899]
12363  Casp4; caspase 4, apoptosis-related cysteine peptidase [KO:K04394] [EC:3.4.22.57 3.4.22.64]
69146  Gsdmd; gasdermin D [KO:K20917]
15975  Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976  Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
54721  Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20846  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
16391  Irf9; interferon regulatory factor 9 [KO:K04693]
21898  Tlr4; toll-like receptor 4 [KO:K10160]
106759  Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842]
17874  Myd88; myeloid differentiation primary response gene 88 [KO:K04729]
266632  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
72512  Sting1; stimulator of interferon response cGAMP interactor 1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
mmu04010  MAPK signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04140  Autophagy - animal
mmu04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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