Entry
Name
JAK-STAT signaling pathway - Mus musculus (house mouse)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
16184 Il2ra; interleukin 2 receptor, alpha chain [KO:K05068 ]
16185 Il2rb; interleukin 2 receptor, beta chain [KO:K05069 ]
16186 Il2rg; interleukin 2 receptor, gamma chain [KO:K05070 ]
16169 Il15ra; interleukin 15 receptor, alpha chain [KO:K05074 ]
57914 Crlf2; cytokine receptor-like factor 2 [KO:K05078 ]
12981 Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427 ]
16188 Il3ra; interleukin 3 receptor, alpha chain [KO:K04737 ]
12982 Csf2ra; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066 ]
12984 Csf2rb2; colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [KO:K04738 ]
12983 Csf2rb; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738 ]
56708 Clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421 ]
16195 Il6st; interleukin 6 signal transducer [KO:K05060 ]
16157 Il11ra1; interleukin 11 receptor subunit alpha 1 [KO:K05056 ]
16158 Il11ra2; interleukin 11 receptor subunit alpha 2 [KO:K05056 ]
16164 Il13ra1; interleukin 13 receptor, alpha 1 [KO:K05076 ]
16165 Il13ra2; interleukin 13 receptor, alpha 2 [KO:K05077 ]
50931 Il27ra; interleukin 27 receptor, alpha [KO:K19598 ]
12804 Cntfr; ciliary neurotrophic factor receptor [KO:K05059 ]
16154 Il10ra; interleukin 10 receptor, alpha [KO:K05134 ]
16155 Il10rb; interleukin 10 receptor, beta [KO:K05135 ]
230828 Il22ra1; interleukin 22 receptor, alpha 1 [KO:K05138 ]
237310 Il22ra2; interleukin 22 receptor, alpha 2 [KO:K05139 ]
83430 Il23a; interleukin 23, alpha subunit p19 [KO:K05426 ]
16161 Il12rb1; interleukin 12 receptor, beta 1 [KO:K05063 ]
16162 Il12rb2; interleukin 12 receptor, beta 2 [KO:K05064 ]
19111 Prl6a1; prolactin family 6, subfamily a, member 1 [KO:K05439 ]
28078 Prl5a1; prolactin family 5, subfamily a, member 1 [KO:K05439 ]
12985 Csf3; colony stimulating factor 3 (granulocyte) [KO:K05423 ]
17480 Mpl; myeloproliferative leukemia virus oncogene [KO:K05082 ]
12986 Csf3r; colony stimulating factor 3 receptor [KO:K05061 ]
15975 Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130 ]
15976 Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131 ]
18590 Pdgfa; platelet derived growth factor, alpha [KO:K04359 ]
18591 Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386 ]
18595 Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363 ] [EC:2.7.10.1 ]
18596 Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089 ] [EC:2.7.10.1 ]
20846 Stat1; signal transducer and activator of transcription 1 [KO:K11220 ]
20847 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
20848 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
20849 Stat4; signal transducer and activator of transcription 4 [KO:K11222 ]
20850 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
20851 Stat5b; signal transducer and activator of transcription 5B [KO:K11224 ]
20852 Stat6; signal transducer and activator of transcription 6 [KO:K11225 ]
12700 Cish; cytokine inducible SH2-containing protein [KO:K04701 ]
12703 Socs1; suppressor of cytokine signaling 1 [KO:K04694 ]
216233 Socs2; suppressor of cytokine signaling 2 [KO:K04695 ]
12702 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
67296 Socs4; suppressor of cytokine signaling 4 [KO:K04697 ]
56468 Socs5; suppressor of cytokine signaling 5 [KO:K04698 ]
192157 Socs7; suppressor of cytokine signaling 7 [KO:K04699 ]
54607 Socs6; suppressor of cytokine signaling 6 [KO:K04699 ]
17210 Mcl1; myeloid cell leukemia sequence 1 [KO:K02539 ]
12575 Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625 ]
14580 Gfap; glial fibrillary acidic protein [KO:K05640 ]
20844 Stam; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705 ]
56324 Stam2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705 ]
56469 Pias1; protein inhibitor of activated STAT 1 [KO:K04706 ] [EC:2.3.2.-]
17344 Pias2; protein inhibitor of activated STAT 2 [KO:K16063 ] [EC:2.3.2.-]
229615 Pias3; protein inhibitor of activated STAT 3 [KO:K16064 ] [EC:2.3.2.-]
14784 Grb2; growth factor receptor bound protein 2 [KO:K04364 ]
20662 Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
20663 Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
Reference
Authors
Harrison DA
Title
The Jak/STAT pathway.
Journal
Reference
Authors
Kiu H, Nicholson SE
Title
Biology and significance of the JAK/STAT signalling pathways.
Journal
Reference
Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title
Direct effects of type I interferons on cells of the immune system.
Journal
Reference
Authors
Fish EN, Platanias LC
Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal
Reference
Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal
Reference
Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal
Reference
Authors
Zoranovic T, Grmai L, Bach EA
Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal
Reference
Authors
Ungureanu D, Silvennoinen O
Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal
Reference
Authors
Richard AJ, Stephens JM
Title
The role of JAK-STAT signaling in adipose tissue function.
Journal
Reference
Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal
Reference
Authors
Hirano T, Ishihara K, Hibi M
Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal
Reference
Authors
Rane SG, Reddy EP
Title
Janus kinases: components of multiple signaling pathways.
Journal
Reference
Authors
Heim MH
Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal
Reference
Authors
Morris R, Kershaw NJ, Babon JJ
Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal
Reference
Authors
Tzeng HT, Chyuan IT, Lai JH
Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal
Reference
Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal
Related pathway
mmu04060 Cytokine-cytokine receptor interaction
KO pathway
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