KEGG   PATHWAY: mmu04714
Entry
mmu04714                    Pathway                                
Name
Thermogenesis - Mus musculus (house mouse)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
mmu04714  Thermogenesis
mmu04714

Other DBs
GO: 1990845
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
11556  Adrb3; adrenergic receptor, beta 3 [KO:K04143]
14683  Gnas; GNAS complex locus [KO:K04632]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
271639  Adcy10; adenylate cyclase 10 [KO:K11265] [EC:4.6.1.1]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12913  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
26427  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
208647  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
208677  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
78284  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
231991  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
70673  Prdm16; PR domain containing 16 [KO:K22410] [EC:2.1.1.367]
329003  Zfp516; zinc finger protein 516 [KO:K22411]
99982  Kdm1a; lysine (K)-specific demethylase 1A [KO:K11450] [EC:1.14.99.66]
22227  Ucp1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
104263  Kdm3a; lysine (K)-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
277250  Kdm3b; KDM3B lysine (K)-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
67155  Smarca2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [KO:K11647] [EC:5.6.2.-]
20586  Smarca4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [KO:K11647] [EC:5.6.2.-]
20587  Smarcb1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [KO:K11648]
20588  Smarcc1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [KO:K11649]
68094  Smarcc2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 [KO:K11649]
83797  Smarcd1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 [KO:K11650]
83796  Smarcd2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [KO:K11650]
66993  Smarcd3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 [KO:K11650]
57376  Smarce1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [KO:K11651]
11465  Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
11461  Actb; actin, beta [KO:K05692]
56456  Actl6a; actin-like 6A [KO:K11340]
83766  Actl6b; actin-like 6B [KO:K11652]
239985  Arid1b; AT-rich interaction domain 1B [KO:K11653]
93760  Arid1a; AT-rich interaction domain 1A [KO:K11653]
29861  Dpf1; double PHD fingers 1 [KO:K22198]
70127  Dpf3; double PHD fingers 3 [KO:K22198]
19016  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26397  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
19017  Ppargc1a; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [KO:K07202]
11909  Atf2; activating transcription factor 2 [KO:K04450]
50721  Sirt6; sirtuin 6 [KO:K11416] [EC:2.3.1.286]
56636  Fgf21; fibroblast growth factor 21 [KO:K22429]
103968  Plin1; perilipin 1 [KO:K08768]
16890  Lipe; lipase, hormone sensitive [KO:K07188] [EC:3.1.1.79]
66853  Pnpla2; patatin-like phospholipase domain containing 2 [KO:K16816] [EC:3.1.1.3]
23945  Mgll; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
105787  Prkaa1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.31]
108079  Prkaa2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.31]
19079  Prkab1; protein kinase, AMP-activated, beta 1 non-catalytic subunit [KO:K07199]
108097  Prkab2; protein kinase, AMP-activated, beta 2 non-catalytic subunit [KO:K07199]
19082  Prkag1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit [KO:K07200]
241113  Prkag3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit [KO:K07200]
108099  Prkag2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit [KO:K07200]
14526  Gcg; glucagon [KO:K05259]
12164  Bmp8b; bone morphogenetic protein 8b [KO:K16622]
12163  Bmp8a; bone morphogenetic protein 8a [KO:K16622]
12801  Cnr1; cannabinoid receptor 1 [KO:K04277]
230899  Nppa; natriuretic peptide type A [KO:K12334]
18158  Nppb; natriuretic peptide type B [KO:K12335]
18160  Npr1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
19091  Prkg1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
19092  Prkg2; protein kinase, cGMP-dependent, type II [KO:K19477] [EC:2.7.11.12]
83379  Klb; klotho beta [KO:K22404]
14182  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
327826  Frs2; fibroblast growth factor receptor substrate 2 [KO:K12461]
14784  Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
20663  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
110651  Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
20111  Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
20112  Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
67071  Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
64930  Tsc1; TSC complex subunit 1 [KO:K07206]
22084  Tsc2; TSC complex subunit 2 [KO:K07207]
19744  Rheb; Ras homolog enriched in brain [KO:K07208]
74370  Rptor; regulatory associated protein of MTOR, complex 1 [KO:K07204]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
56716  Mlst8; MTOR associated protein, LST8 homolog (S. cerevisiae) [KO:K08266]
67605  Akt1s1; AKT1 substrate 1 [KO:K16184]
58988  Rps6kb2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04688] [EC:2.7.11.1]
72508  Rps6kb1; ribosomal protein S6 kinase, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
20104  Rps6; ribosomal protein S6 [KO:K02991]
216036  Gm4796; predicted gene 4796 [KO:K02991]
14081  Acsl1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
50790  Acsl4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
216739  Acsl6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
74205  Acsl3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
433256  Acsl5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
69702  Ndufaf1; NADH:ubiquinone oxidoreductase complex assembly factor 1 [KO:K18159]
75597  Ndufaf2; NADH:ubiquinone oxidoreductase complex assembly factor 2 [KO:K18160]
66706  Ndufaf3; NADH:ubiquinone oxidoreductase complex assembly factor 3 [KO:K09008]
68493  Ndufaf4; NADH:ubiquinone oxidoreductase complex assembly factor 4 [KO:K18161]
69487  Ndufaf5; NADH:ubiquinone oxidoreductase complex assembly factor 5 [KO:K18162] [EC:2.1.1.-]
76947  Ndufaf6; NADH:ubiquinone oxidoreductase complex assembly factor 6 [KO:K18163]
73694  Ndufaf7; NADH:ubiquinone oxidoreductase complex assembly factor 7 [KO:K18164]
208501  Ndufaf8; NADH:ubiquinone oxidoreductase complex assembly factor 8 [KO:K24726]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
17711  CYTB; cytochrome b [KO:K00412]
66445  Cyc1; cytochrome c-1 [KO:K00413]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
70383  Cox10; heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 [KO:K02257] [EC:2.5.1.141]
69802  Cox11; cytochrome c oxidase assembly protein 11, copper chaperone [KO:K02258]
101055854  Gm29733; predicted gene, 29733 [KO:K18181]
66379  Cox14; cytochrome c oxidase assembly protein 14 [KO:K18181]
226139  Cox15; cytochrome c oxidase assembly protein 15 [KO:K02259] [EC:1.17.99.9]
66272  Cox16; cytochrome c oxidase assembly protein 16 [KO:K18182]
12856  Cox17; cytochrome c oxidase assembly protein 17, copper chaperone [KO:K02260]
231430  Cox18; cytochrome c oxidase assembly protein 18 [KO:K17797]
68033  Cox19; cytochrome c oxidase assembly protein 19 [KO:K18183]
66359  Cox20; cytochrome c oxidase assembly protein 20 [KO:K18184]
52469  Coa3; cytochrome C oxidase assembly factor 3 [KO:K18175]
68185  Coa4; cytochrome c oxidase assembly factor 4 [KO:K18177]
76178  Coa5; cytochrome C oxidase assembly factor 5 [KO:K18178]
67892  Coa6; cytochrome c oxidase assembly factor 6 [KO:K18179]
69893  Coa7; cytochrome c oxidase assembly factor 7 [KO:K18180]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
11958  Atp5me; ATP synthase membrane subunit e [KO:K02129]
57423  Atp5mf; ATP synthase membrane subunit f [KO:K02130]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
27425  Atp5mg; ATP synthase membrane subunit g [KO:K02140]
12896  Cpt2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
214663  Slc25a29; solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 [KO:K15109]
57279  Slc25a20; solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 [KO:K15109]
12894  Cpt1a; carnitine palmitoyltransferase 1a, liver [KO:K08765] [EC:2.3.1.21]
12895  Cpt1b; carnitine palmitoyltransferase 1b, muscle [KO:K19523] [EC:2.3.1.21]
78070  Cpt1c; carnitine palmitoyltransferase 1c [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
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Related
pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00190  Oxidative phosphorylation
mmu04010  MAPK signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04024  cAMP signaling pathway
mmu04150  mTOR signaling pathway
mmu04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
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