KEGG   PATHWAY: mmu04810
Entry
mmu04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Mus musculus (house mouse)
Class
Cellular Processes; Cell motility
Pathway map
mmu04810  Regulation of actin cytoskeleton
mmu04810

Other DBs
GO: 0030036
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
14745  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
53978  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
78134  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
381810  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
20315  Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031]
12767  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
14061  F2; coagulation factor II [KO:K01313] [EC:3.4.21.5]
14062  F2r; coagulation factor II thrombin receptor [KO:K03914]
16334  Ins2; insulin II [KO:K04526]
16333  Ins1; insulin I [KO:K04526]
13645  Egf; epidermal growth factor [KO:K04357]
14164  Fgf1; fibroblast growth factor 1 [KO:K18496]
14173  Fgf2; fibroblast growth factor 2 [KO:K18497]
14174  Fgf3; fibroblast growth factor 3 [KO:K04358]
14175  Fgf4; fibroblast growth factor 4 [KO:K04358]
14176  Fgf5; fibroblast growth factor 5 [KO:K04358]
14178  Fgf7; fibroblast growth factor 7 [KO:K04358]
14179  Fgf8; fibroblast growth factor 8 [KO:K04358]
14180  Fgf9; fibroblast growth factor 9 [KO:K04358]
14165  Fgf10; fibroblast growth factor 10 [KO:K04358]
80903  Fgf16; fibroblast growth factor 16 [KO:K04358]
14171  Fgf17; fibroblast growth factor 17 [KO:K04358]
14172  Fgf18; fibroblast growth factor 18 [KO:K04358]
80857  Fgf20; fibroblast growth factor 20 [KO:K04358]
67112  Fgf22; fibroblast growth factor 22 [KO:K04358]
14177  Fgf6; fibroblast growth factor 6 [KO:K04358]
14170  Fgf15; fibroblast growth factor 15 [KO:K22603]
56636  Fgf21; fibroblast growth factor 21 [KO:K22429]
64654  Fgf23; fibroblast growth factor 23 [KO:K22428]
18590  Pdgfa; platelet derived growth factor, alpha [KO:K04359]
18591  Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386]
54635  Pdgfc; platelet-derived growth factor, C polypeptide [KO:K05450]
71785  Pdgfd; platelet-derived growth factor, D polypeptide [KO:K05450]
23920  Insrr; insulin receptor-related receptor [KO:K05086] [EC:2.7.10.1]
13649  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
14182  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
14183  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
14184  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
14186  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
18595  Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
18596  Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
14268  Fn1; fibronectin 1 [KO:K05717]
109700  Itga1; integrin alpha 1 [KO:K06480]
16398  Itga2; integrin alpha 2 [KO:K06481]
16399  Itga2b; integrin alpha 2b [KO:K06476]
16400  Itga3; integrin alpha 3 [KO:K06482]
16401  Itga4; integrin alpha 4 [KO:K06483]
16402  Itga5; integrin alpha 5 (fibronectin receptor alpha) [KO:K06484]
16403  Itga6; integrin alpha 6 [KO:K06485]
16404  Itga7; integrin alpha 7 [KO:K06583]
241226  Itga8; integrin alpha 8 [KO:K06584]
104099  Itga9; integrin alpha 9 [KO:K06585]
213119  Itga10; integrin, alpha 10 [KO:K06586]
319480  Itga11; integrin alpha 11 [KO:K06587]
16410  Itgav; integrin alpha V [KO:K06487]
16408  Itgal; integrin alpha L [KO:K05718]
16409  Itgam; integrin alpha M [KO:K06461]
16411  Itgax; integrin alpha X [KO:K06462]
381924  Itgad; integrin, alpha D [KO:K06594]
16407  Itgae; integrin alpha E, epithelial-associated [KO:K06524]
16412  Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719]
16414  Itgb2; integrin beta 2 [KO:K06464]
16415  Itgb2l; integrin beta 2-like [KO:K06464]
16416  Itgb3; integrin beta 3 [KO:K06493]
192897  Itgb4; integrin beta 4 [KO:K06525]
16419  Itgb5; integrin beta 5 [KO:K06588]
16420  Itgb6; integrin beta 6 [KO:K06589]
16421  Itgb7; integrin beta 7 [KO:K06590]
320910  Itgb8; integrin beta 8 [KO:K06591]
16644  Kng1; kininogen 1 [KO:K03898]
385643  Kng2; kininogen 2 [KO:K03898]
12061  Bdkrb1; bradykinin receptor, beta 1 [KO:K03915]
12062  Bdkrb2; bradykinin receptor, beta 2 [KO:K03916]
12669  Chrm1; cholinergic receptor, muscarinic 1, CNS [KO:K04129]
243764  Chrm2; cholinergic receptor, muscarinic 2, cardiac [KO:K04130]
12671  Chrm3; cholinergic receptor, muscarinic 3, cardiac [KO:K04131]
12672  Chrm4; cholinergic receptor, muscarinic 4 [KO:K04132]
213788  Chrm5; cholinergic receptor, muscarinic 5 [KO:K04133]
15139  Hc; hemolytic complement [KO:K03994]
12274  C6; complement component 6 [KO:K03995]
109828  C7; complement component 7 [KO:K03996]
230558  C8a; complement component 8, alpha polypeptide [KO:K03997]
110382  C8b; complement component 8, beta polypeptide [KO:K03998]
69379  C8g; complement component 8, gamma polypeptide [KO:K03999]
12279  C9; complement component 9 [KO:K04000]
14673  Gna12; guanine nucleotide binding protein, alpha 12 [KO:K04346]
14674  Gna13; guanine nucleotide binding protein, alpha 13 [KO:K04639]
14701  Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
100503710  Gng14; G protein subunit gamma 14 [KO:K04347]
14163  Fgd1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
30938  Fgd3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
12927  Bcar1; breast cancer anti-estrogen resistance 1 [KO:K05726]
12928  Crk; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
12929  Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
330662  Dock1; dedicator of cytokinesis 1 [KO:K13708]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20662  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
20663  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
20130  Rras; related RAS viral (r-ras) oncogene [KO:K07829]
66922  Rras2; related RAS viral (r-ras) oncogene 2 [KO:K07830]
17532  Mras; muscle and microspikes RAS [KO:K07831]
73341  Arhgef6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
22324  Vav1; vav 1 oncogene [KO:K05730]
22325  Vav2; vav 2 oncogene [KO:K05730]
57257  Vav3; vav 3 oncogene [KO:K05730]
21844  Tiam1; T cell lymphoma invasion and metastasis 1 [KO:K05731]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
17451  Mos; Moloney sarcoma oncogene [KO:K04367] [EC:2.7.11.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
66214  Rgcc; regulator of cell cycle [KO:K26108]
16801  Arhgef1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
69632  Arhgef12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
232906  Arhgap35; Rho GTPase activating protein 35 [KO:K05732]
11848  Rhoa; ras homolog family member A [KO:K04513]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
19354  Rac2; Rac family small GTPase 2 [KO:K07860]
170758  Rac3; Rac family small GTPase 3 [KO:K07861]
12540  Cdc42; cell division cycle 42 [KO:K04393]
18479  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
224105  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
18481  Pak3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
70584  Pak4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
241656  Pak5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
214230  Pak6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
54126  Arhgef7; Rho guanine nucleotide exchange factor [KO:K13710]
216963  Git1; GIT ArfGAP 1 [KO:K05737]
19877  Rock1; Rho-associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
19878  Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
107589  Mylk; myosin, light polypeptide kinase [KO:K00907] [EC:2.7.11.18]
213435  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
228785  Mylk2; myosin, light polypeptide kinase 2, skeletal muscle [KO:K00907] [EC:2.7.11.18]
238564  Mylk4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
19045  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
19046  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
19047  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
434233  Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B [KO:K06269] [EC:3.1.3.16]
17931  Ppp1r12a; protein phosphatase 1, regulatory subunit 12A [KO:K06270]
329251  Ppp1r12b; protein phosphatase 1, regulatory subunit 12B [KO:K12329]
232807  Ppp1r12c; protein phosphatase 1, regulatory subunit 12C [KO:K17457]
17906  Myl2; myosin, light polypeptide 2, regulatory, cardiac, slow [KO:K10351]
17898  Myl7; myosin, light polypeptide 7, regulatory [KO:K12754]
98932  Myl9; myosin, light polypeptide 9, regulatory [KO:K12755]
59310  Myl10; myosin, light chain 10, regulatory [KO:K12756]
67938  Myl12b; myosin, light chain 12B, regulatory [KO:K12757]
67268  Myl12a; myosin, light chain 12A, regulatory, non-sarcomeric [KO:K12757]
17907  Mylpf; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
17880  Myh11; myosin, heavy polypeptide 11, smooth muscle [KO:K10352]
17886  Myh9; myosin, heavy polypeptide 9, non-muscle [KO:K10352]
71960  Myh14; myosin, heavy polypeptide 14 [KO:K10352]
77579  Myh10; myosin, heavy polypeptide 10, non-muscle [KO:K10352]
13367  Diaph1; diaphanous related formin 1 [KO:K05740]
54004  Diaph2; diaphanous related formin 2 [KO:K05741]
20544  Slc9a1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 [KO:K05742]
18717  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma [KO:K00889] [EC:2.7.1.68]
18719  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [KO:K00889] [EC:2.7.1.68]
18720  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [KO:K00889] [EC:2.7.1.68]
117150  Pip4k2c; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
18718  Pip4k2a; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
108083  Pip4k2b; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
18711  Pikfyve; phosphoinositide kinase, FYVE type zinc finger containing [KO:K00921] [EC:2.7.1.150]
16885  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
16886  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
56419  Diaph3; diaphanous related formin 3 [KO:K05745]
108100  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
13800  Enah; ENAH actin regulator [KO:K05746]
73178  Wasl; WASP like actin nucleation promoting factor [KO:K23612]
242687  Wasf2; WASP family, member 2 [KO:K05748]
20430  Cyfip1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
76884  Cyfip2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
105855  Nckap1l; NCK associated protein 1 like [KO:K05750]
50884  Nckap1; NCK-associated protein 1 [KO:K05750]
329165  Abi2; abl interactor 2 [KO:K05751]
101314  Brk1; BRICK1, SCAR/WAVE actin-nucleating complex subunit [KO:K05752]
83767  Wasf1; WASP family, member 1 [KO:K05753]
66713  Actr2; actin related protein 2 [KO:K17260]
242894  Actr3b; ARP3 actin-related protein 3B [KO:K18584]
74117  Actr3; ARP3 actin-related protein 3 [KO:K18584]
11867  Arpc1b; actin related protein 2/3 complex, subunit 1B [KO:K05757]
56443  Arpc1a; actin related protein 2/3 complex, subunit 1A [KO:K05757]
434782  Gm5637; predicted pseudogene 5637 [KO:K05757]
76709  Arpc2; actin related protein 2/3 complex, subunit 2 [KO:K05758]
56378  Arpc3; actin related protein 2/3 complex, subunit 3 [KO:K05756]
68089  Arpc4; actin related protein 2/3 complex, subunit 4 [KO:K05755]
67771  Arpc5; actin related protein 2/3 complex, subunit 5 [KO:K05754]
74192  Arpc5l; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
11465  Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
11461  Actb; actin, beta [KO:K05692]
18643  Pfn1; profilin 1 [KO:K05759]
18645  Pfn2; profilin 2 [KO:K05759]
75477  Pfn3; profilin 3 [KO:K05759]
382562  Pfn4; profilin family, member 4 [KO:K05759]
19303  Pxn; paxillin [KO:K05760]
22350  Ezr; ezrin [KO:K08007]
19684  Rdx; radixin [KO:K05762]
17698  Msn; moesin [KO:K05763]
19241  Tmsb4x; thymosin, beta 4, X chromosome [KO:K05764]
12631  Cfl1; cofilin 1, non-muscle [KO:K05765]
12632  Cfl2; cofilin 2, muscle [KO:K05765]
231637  Ssh1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
237860  Ssh2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
245857  Ssh3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
22330  Vcl; vinculin [KO:K05700]
29875  Iqgap1; IQ motif containing GTPase activating protein 1 [KO:K16848]
544963  Iqgap2; IQ motif containing GTPase activating protein 2 [KO:K05767]
404710  Iqgap3; IQ motif containing GTPase activating protein 3 [KO:K05767]
227753  Gsn; gelsolin [KO:K05768]
20259  Scin; scinderin [KO:K05768]
60595  Actn4; actinin alpha 4 [KO:K05699]
109711  Actn1; actinin, alpha 1 [KO:K05699]
11789  Apc; APC, WNT signaling pathway regulator [KO:K02085]
23805  Apc2; APC regulator of WNT signaling pathway 2 [KO:K02085]
226970  Arhgef4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
219140  Spata13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mmu04010  MAPK signaling pathway
mmu04510  Focal adhesion
mmu04520  Adherens junction
KO pathway
ko04810   
LinkDB

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