Entry
Name
Prolactin signaling pathway - Mus musculus (house mouse)
Description
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
19111 Prl6a1; prolactin family 6, subfamily a, member 1 [KO:K05439 ]
28078 Prl5a1; prolactin family 5, subfamily a, member 1 [KO:K05439 ]
20416 Shc1; src homology 2 domain-containing transforming protein C1 [KO:K06279 ]
216148 Shc2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K17447 ]
20418 Shc3; src homology 2 domain-containing transforming protein C3 [KO:K17448 ]
271849 Shc4; SHC (Src homology 2 domain containing) family, member 4 [KO:K17449 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
14784 Grb2; growth factor receptor bound protein 2 [KO:K04364 ]
20662 Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
20663 Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
12700 Cish; cytokine inducible SH2-containing protein [KO:K04701 ]
12703 Socs1; suppressor of cytokine signaling 1 [KO:K04694 ]
216233 Socs2; suppressor of cytokine signaling 2 [KO:K04695 ]
12702 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
67296 Socs4; suppressor of cytokine signaling 4 [KO:K04697 ]
56468 Socs5; suppressor of cytokine signaling 5 [KO:K04698 ]
192157 Socs7; suppressor of cytokine signaling 7 [KO:K04699 ]
54607 Socs6; suppressor of cytokine signaling 6 [KO:K04699 ]
20846 Stat1; signal transducer and activator of transcription 1 [KO:K11220 ]
20848 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
20850 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
20851 Stat5b; signal transducer and activator of transcription 5B [KO:K11224 ]
21943 Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11 [KO:K05473 ]
21934 Tnfrsf11a; tumor necrosis factor receptor superfamily, member 11a, NFKB activator [KO:K05147 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
12640 Cga; glycoprotein hormones, alpha subunit [KO:K08522 ]
16867 Lhcgr; luteinizing hormone/choriogonadotropin receptor [KO:K04248 ]
20526 Slc2a2; solute carrier family 2 (facilitated glucose transporter), member 2 [KO:K07593 ]
Compound
C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Binart N, Bachelot A, Bouilly J
Title
Impact of prolactin receptor isoforms on reproduction.
Journal
Reference
Authors
Bachelot A, Binart N
Title
Reproductive role of prolactin.
Journal
Reference
Authors
Hennighausen L, Robinson GW
Title
Information networks in the mammary gland.
Journal
Reference
Authors
Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title
Prolactin signaling mechanisms in ovary.
Journal
Reference
Authors
Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title
Prolactin regulation of mammary gland development.
Journal
Reference
Authors
Frasor J, Gibori G
Title
Prolactin regulation of estrogen receptor expression.
Journal
Reference
Authors
Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title
Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal
Reference
Authors
Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title
Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal
Reference
Authors
Grattan DR, Kokay IC
Title
Prolactin: a pleiotropic neuroendocrine hormone.
Journal
Reference
Authors
Yu-Lee LY, Luo G, Book ML, Morris SM
Title
Lactogenic hormone signal transduction.
Journal
Reference
Authors
Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title
Tissue-specific induction of SOCS gene expression by PRL.
Journal
Reference
Authors
Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title
Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal
Reference
Authors
Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal
Reference
Authors
Oakes SR, Hilton HN, Ormandy CJ
Title
The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
Journal
Related pathway
KO pathway
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