KEGG   PATHWAY: mmu05014
Entry
mmu05014                    Pathway                                
Name
Amyotrophic lateral sclerosis - Mus musculus (house mouse)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmu05014  Amyotrophic lateral sclerosis
mmu05014

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
22059  Trp53; transformation related protein 53 [KO:K04451]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
12028  Bax; BCL2-associated X protein [KO:K02159]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
20655  Sod1; superoxide dismutase 1, soluble [KO:K04565] [EC:1.15.1.1]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
17711  CYTB; cytochrome b [KO:K00412]
66445  Cyc1; cytochrome c-1 [KO:K00413]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
53333  Tomm40; translocase of outer mitochondrial membrane 40 [KO:K11518]
641376  Tomm40l; translocase of outer mitochondrial membrane 40-like [KO:K11518]
215999  Mcu; mitochondrial calcium uniporter [KO:K20858]
68943  Pink1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
50873  Prkn; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
71648  Optn; optineurin [KO:K19946]
18412  Sqstm1; sequestosome 1 [KO:K14381]
66734  Map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435]
67443  Map1lc3b; microtubule-associated protein 1 light chain 3 beta [KO:K10435]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
21353  Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650]
218460  Wdr41; WD repeat domain 41 [KO:K23610]
237782  Smcr8; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) [KO:K23611]
73205  C9orf72; C9orf72, member of C9orf72-SMCR8 complex [KO:K23609]
17274  Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
67790  Rab39b; RAB39B, member RAS oncogene family [KO:K07925]
19324  Rab1a; RAB1A, member RAS oncogene family [KO:K07874]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
22241  Ulk1; unc-51 like kinase 1 [KO:K21357] [EC:2.7.11.1]
29869  Ulk2; unc-51 like kinase 2 [KO:K08269] [EC:2.7.11.1]
68118  Atg101; autophagy related 101 [KO:K19730]
51897  Atg13; autophagy related 13 [KO:K08331]
12421  Rb1cc1; RB1-inducible coiled-coil 1 [KO:K17589]
228361  Ambra1; autophagy/beclin 1 regulator 1 [KO:K17985]
56208  Becn1; beclin 1, autophagy related [KO:K08334]
75669  Pik3r4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100504663  Atg14; autophagy related 14 [KO:K17889]
641340  Nrbf2; nuclear receptor binding factor 2 [KO:K21246]
225326  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
329015  Atg2a; autophagy related 2A [KO:K17906]
76559  Atg2b; autophagy related 2B [KO:K17906]
52639  Wipi1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
74781  Wipi2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
74018  Als2; alsin Rho guanine nucleotide exchange factor [KO:K04575]
271457  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
68942  Chmp2b; charged multivesicular body protein 2B [KO:K12192]
103199  Fig4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
214585  Spg11; SPG11, spatacsin vesicle trafficking associated [KO:K19026]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
56085  Ubqln1; ubiquilin 1 [KO:K04523]
244178  Ubqln3; ubiquilin 3 [KO:K04523]
54609  Ubqln2; ubiquilin 2 [KO:K04523]
94232  Ubqln4; ubiquilin 4 [KO:K04523]
269523  Vcp; valosin containing protein [KO:K13525]
67819  Derl1; Der1-like domain family, member 1 [KO:K11519]
26443  Psma6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
19166  Psma2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
26441  Psma4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
26444  Psma7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
73677  Psma8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
26442  Psma5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
26440  Psma1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
19167  Psma3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
19175  Psmb6; proteasome (prosome, macropain) subunit, beta type 6 [KO:K02738] [EC:3.4.25.1]
19177  Psmb7; proteasome (prosome, macropain) subunit, beta type 7 [KO:K02739] [EC:3.4.25.1]
26446  Psmb3; proteasome (prosome, macropain) subunit, beta type 3 [KO:K02735] [EC:3.4.25.1]
26445  Psmb2; proteasome (prosome, macropain) subunit, beta type 2 [KO:K02734] [EC:3.4.25.1]
19173  Psmb5; proteasome (prosome, macropain) subunit, beta type 5 [KO:K02737] [EC:3.4.25.1]
19170  Psmb1; proteasome (prosome, macropain) subunit, beta type 1 [KO:K02732] [EC:3.4.25.1]
19172  Psmb4; proteasome (prosome, macropain) subunit, beta type 4 [KO:K02736] [EC:3.4.25.1]
19181  Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061]
19179  Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
23996  Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
67089  Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
19182  Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065]
19184  Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066]
21762  Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
70247  Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
22123  Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
67151  Psmd9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [KO:K06693]
66997  Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
69077  Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
66413  Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
17463  Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
23997  Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
19185  Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
59029  Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
57296  Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
56436  Adrm1; adhesion regulating molecule 1 26S proteasome ubiquitin receptor [KO:K06691]
20422  Sem1; SEM1, 26S proteasome complex subunit [KO:K10881]
15185  Hdac6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
230908  Tardbp; TAR DNA binding protein [KO:K23600]
233908  Fus; fused in sarcoma [KO:K13098]
15382  Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
229279  Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
545091  Hnrnpa1l2-ps2; heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 [KO:K12741]
53379  Hnrnpa2b1; heterogeneous nuclear ribonucleoprotein A2/B1 [KO:K13158]
20239  Atxn2; ataxin 2 [KO:K23625]
233871  Atxn2l; ataxin 2-like [KO:K23625]
17184  Matr3; matrin 3 [KO:K13213]
11727  Ang; angiogenin, ribonuclease, RNase A family, 5 [KO:K16631] [EC:3.1.27.-]
11731  Ang2; angiogenin, ribonuclease A family, member 2 [KO:K16631] [EC:3.1.27.-]
219033  Ang4; angiogenin, ribonuclease A family, member 4 [KO:K16631] [EC:3.1.27.-]
503844  Ang5; angiogenin, ribonuclease A family, member 5 [KO:K16631] [EC:3.1.27.-]
11730  Ang3; angiogenin, ribonuclease A family, member 3 [KO:K16631] [EC:3.1.27.-]
630952  Ang6; angiogenin, ribonuclease A family, member 6 [KO:K16631] [EC:3.1.27.-]
433702  Ncbp1; nuclear cap binding protein subunit 1 [KO:K12882]
21681  Alyref; Aly/REF export factor [KO:K12881]
56009  Alyref2; Aly/REF export factor 2 [KO:K12881]
100043292  Alyreffm10; Aly/REF export factor family member 10 [KO:K12881]
100861880  Alyreffm11; Aly/REF export factor family member 11 [KO:K12881]
20383  Srsf3; serine and arginine-rich splicing factor 3 [KO:K12892]
225027  Srsf7; serine and arginine-rich splicing factor 7 [KO:K12896]
53319  Nxf1; nuclear RNA export factor 1 [KO:K14284]
170722  Nxf7; nuclear RNA export factor 7 [KO:K14284]
83454  Nxf2; nuclear RNA export factor 2 [KO:K14284]
245610  Nxf3; nuclear RNA export factor 3 [KO:K14284]
56488  Nxt1; NTF2-related export protein 1 [KO:K14285]
237082  Nxt2; nuclear transport factor 2-like export factor 2 [KO:K14285]
74412  Gle1; GLE1 RNA export mediator [KO:K18723]
108989  Tpr; translocated promoter region, nuclear basket protein [KO:K09291]
18141  Nup50; nucleoporin 50 [KO:K14295]
218210  Nup153; nucleoporin 153 [KO:K14296]
269966  Nup98; nucleoporin 98 [KO:K14297]
66679  Rae1; ribonucleic acid export 1 [KO:K14298]
110379  Sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
72124  Seh1l; SEH1-like (S. cerevisiae [KO:K14299]
234865  Nup133; nucleoporin 133 [KO:K14300]
103468  Nup107; nucleoporin 107 [KO:K14301]
69736  Nup37; nucleoporin 37 [KO:K14302]
59015  Nup160; nucleoporin 160 [KO:K14303]
445007  Nup85; nucleoporin 85 [KO:K14304]
69912  Nup43; nucleoporin 43 [KO:K14305]
18226  Nup62; nucleoporin 62 [KO:K14306]
71844  Nup58; nucleoporin 58 [KO:K14307]
269113  Nup54; nucleoporin 54 [KO:K14308]
71805  Nup93; nucleoporin 93 [KO:K14309]
70699  Nup205; nucleoporin 205 [KO:K14310]
227699  Nup188; nucleoporin 188 [KO:K14311]
170762  Nup155; nucleoporin 155 [KO:K14312]
69482  Nup35; nucleoporin 35 [KO:K14313]
54563  Nup210; nucleoporin 210 [KO:K14314]
77595  Nup210l; nucleoporin 210-like [KO:K14314]
72787  Ndc1; NDC1 transmembrane nucleoporin [KO:K14315]
107939  Pom121; nuclear pore membrane protein 121 [KO:K14316]
195236  Pom121l2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
227720  Nup214; nucleoporin 214 [KO:K14317]
19069  Nup88; nucleoporin 88 [KO:K14318]
19386  Ranbp2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
269254  Setx; senataxin [KO:K10706] [EC:5.6.2.5 5.6.2.3]
103172  Chchd10; coiled-coil-helix-coiled-coil-helix domain containing 10 [KO:K22759]
14828  Hspa5; heat shock protein 5 [KO:K09490] [EC:3.6.4.10]
56491  Vapb; vesicle-associated membrane protein, associated protein B and C [KO:K10707]
226641  Atf6; activating transcription factor 6 [KO:K09054]
13198  Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
78943  Ern1; endoplasmic reticulum to nucleus signalling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
22433  Xbp1; X-box binding protein 1 [KO:K09027]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
12364  Casp12; caspase 12 [KO:K04741] [EC:3.4.22.-]
13666  Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
13665  Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
11911  Atf4; activating transcription factor 4 [KO:K04374]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
18391  Sigmar1; sigma non-opioid intracellular receptor 1 [KO:K20719]
21926  Tnf; tumor necrosis factor [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
21938  Tnfrsf1b; tumor necrosis factor receptor superfamily, member 1b [KO:K05141]
13163  Daxx; Fas death domain-associated protein [KO:K02308]
26397  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
12460  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
14775  Gpx1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
14776  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
14778  Gpx3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
14780  Gpx5; glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
67305  Gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
75512  Gpx6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
69590  Gpx8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
12359  Cat; catalase [KO:K03781] [EC:1.11.1.6]
19132  Prph; peripherin [KO:K07607]
18039  Nefl; neurofilament, light polypeptide [KO:K04572]
18040  Nefm; neurofilament, medium polypeptide [KO:K04573]
380684  Nefh; neurofilament, heavy polypeptide [KO:K04574]
18643  Pfn1; profilin 1 [KO:K05759]
18645  Pfn2; profilin 2 [KO:K05759]
75477  Pfn3; profilin 3 [KO:K05759]
382562  Pfn4; profilin family, member 4 [KO:K05759]
11465  Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
11461  Actb; actin, beta [KO:K05692]
11750  Anxa7; annexin A7 [KO:K17095]
11744  Anxa11; annexin A11 [KO:K17095]
16572  Kif5a; kinesin family member 5A [KO:K10396]
16573  Kif5b; kinesin family member 5B [KO:K10396]
16574  Kif5c; kinesin family member 5C [KO:K10396]
16593  Klc1; kinesin light chain 1 [KO:K10407]
16594  Klc2; kinesin light chain 2 [KO:K10407]
232943  Klc3; kinesin light chain 3 [KO:K10407]
74764  Klc4; kinesin light chain 4 [KO:K10407]
22145  Tuba4a; tubulin, alpha 4A [KO:K07374]
22144  Tuba3a; tubulin, alpha 3A [KO:K07374]
22142  Tuba1a; tubulin, alpha 1A [KO:K07374]
22146  Tuba1c; tubulin, alpha 1C [KO:K07374]
22147  Tuba3b; tubulin, alpha 3B [KO:K07374]
22143  Tuba1b; tubulin, alpha 1B [KO:K07374]
53857  Tuba8; tubulin, alpha 8 [KO:K07374]
238463  Tubal3; tubulin, alpha-like 3 [KO:K07374]
227613  Tubb4b; tubulin, beta 4B class IVB [KO:K07375]
22151  Tubb2a; tubulin, beta 2A class IIA [KO:K07375]
22152  Tubb3; tubulin, beta 3 class III [KO:K07375]
22153  Tubb4a; tubulin, beta 4A class IVA [KO:K07375]
67951  Tubb6; tubulin, beta 6 class V [KO:K07375]
22154  Tubb5; tubulin, beta 5 class I [KO:K07375]
545486  Tubb1; tubulin, beta 1 class VI [KO:K07375]
73710  Tubb2b; tubulin, beta 2B class IIB [KO:K07375]
13191  Dctn1; dynactin 1 [KO:K04648]
69654  Dctn2; dynactin 2 [KO:K10424]
53598  Dctn3; dynactin 3 [KO:K10425]
67665  Dctn4; dynactin 4 [KO:K10426]
59288  Dctn5; dynactin 5 [KO:K10427]
22428  Dctn6; dynactin 6 [KO:K10428]
54130  Actr1a; ARP1 actin-related protein 1A, centractin alpha [KO:K16575]
226977  Actr1b; ARP1 actin-related protein 1B, centractin beta [KO:K16575]
56444  Actr10; ARP10 actin-related protein 10 [KO:K16576]
15114  Hap1; huntingtin-associated protein 1 [KO:K04647]
110084  Dnah1; dynein, axonemal, heavy chain 1 [KO:K10408]
381917  Dnah3; dynein, axonemal, heavy chain 3 [KO:K10408]
327954  Dnah2; dynein, axonemal, heavy chain 2 [KO:K10408]
227058  Dnah7b; dynein, axonemal, heavy chain 7B [KO:K10408]
110082  Dnah5; dynein, axonemal, heavy chain 5 [KO:K10408]
330355  Dnah6; dynein, axonemal, heavy chain 6 [KO:K10408]
237806  Dnah9; dynein, axonemal, heavy chain 9 [KO:K10408]
13411  Dnah11; dynein, axonemal, heavy chain 11 [KO:K10408]
110083  Dnah12; dynein, axonemal, heavy chain 12 [KO:K10408]
13417  Dnah8; dynein, axonemal, heavy chain 8 [KO:K10408]
627872  Dnah7a; dynein, axonemal, heavy chain 7A [KO:K10408]
56087  Dnah10; dynein, axonemal, heavy chain 10 [KO:K10408]
69926  Dnah17; dynein, axonemal, heavy chain 17 [KO:K10408]
240960  Dnah14; dynein, axonemal, heavy chain 14 [KO:K10408]
100101919  Dnah7c; dynein, axonemal, heavy chain 7C [KO:K10408]
75563  Dnali1; dynein, axonemal, light intermediate polypeptide 1 [KO:K10410]
68922  Dnai1; dynein axonemal intermediate chain 1 [KO:K10409]
432611  Dnai2; dynein axonemal intermediate chain 2 [KO:K11143]
105000  Dnal1; dynein, axonemal, light chain 1 [KO:K10411]
54152  Dnal4; dynein, axonemal, light chain 4 [KO:K10412]
20511  Slc1a2; solute carrier family 1 (glial high affinity glutamate transporter), member 2 [KO:K05613]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
14799  Gria1; glutamate receptor, ionotropic, AMPA1 (alpha 1) [KO:K05197]
14800  Gria2; glutamate receptor, ionotropic, AMPA2 (alpha 2) [KO:K05198]
14810  Grin1; glutamate receptor, ionotropic, NMDA1 (zeta 1) [KO:K05208]
14811  Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209]
14812  Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210]
14813  Grin2c; glutamate receptor, ionotropic, NMDA2C (epsilon 3) [KO:K05211]
14814  Grin2d; glutamate receptor, ionotropic, NMDA2D (epsilon 4) [KO:K05212]
211323  Nrg1; neuregulin 1 [KO:K05455]
100042150  Nrg2; neuregulin 2 [KO:K05456]
18183  Nrg3; neuregulin 3 [KO:K05457]
83961  Nrg4; neuregulin 4 [KO:K05458]
13869  Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
mmu00190  Oxidative phosphorylation
mmu03013  Nucleocytoplasmic transport
mmu03050  Proteasome
mmu04010  MAPK signaling pathway
mmu04012  ErbB signaling pathway
mmu04020  Calcium signaling pathway
mmu04115  p53 signaling pathway
mmu04137  Mitophagy - animal
mmu04140  Autophagy - animal
mmu04141  Protein processing in endoplasmic reticulum
mmu04210  Apoptosis
mmu04724  Glutamatergic synapse
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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