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Entry
Name
Prion disease - Mus musculus (house mouse)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
17967 Ncam1; neural cell adhesion molecule 1 [KO:K06491 ]
17968 Ncam2; neural cell adhesion molecule 2 [KO:K06491 ]
20867 Stip1; stress-induced phosphoprotein 1 [KO:K09553 ]
14810 Grin1; glutamate receptor, ionotropic, NMDA1 (zeta 1) [KO:K05208 ]
14811 Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209 ]
14812 Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210 ]
14813 Grin2c; glutamate receptor, ionotropic, NMDA2C (epsilon 3) [KO:K05211 ]
14814 Grin2d; glutamate receptor, ionotropic, NMDA2D (epsilon 4) [KO:K05212 ]
242443 Grin3a; glutamate receptor ionotropic, NMDA3A [KO:K05213 ]
170483 Grin3b; glutamate receptor, ionotropic, NMDA3B [KO:K05214 ]
12287 Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849 ]
12288 Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850 ]
12289 Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851 ]
54652 Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853 ]
12292 Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857 ]
13666 Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860 ] [EC:2.7.11.1 ]
13665 Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237 ]
11911 Atf4; activating transcription factor 4 [KO:K04374 ]
13198 Ddit3; DNA-damage inducible transcript 3 [KO:K04452 ]
20190 Ryr1; ryanodine receptor 1, skeletal muscle [KO:K04961 ]
16438 Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958 ]
16439 Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959 ]
16440 Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960 ]
19057 Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
19058 Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268 ]
19059 Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268 ]
12015 Bad; BCL2-associated agonist of cell death [KO:K02158 ]
22333 Vdac1; voltage-dependent anion channel 1 [KO:K05862 ]
22334 Vdac2; voltage-dependent anion channel 2 [KO:K15040 ]
22335 Vdac3; voltage-dependent anion channel 3 [KO:K15041 ]
11739 Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863 ]
11740 Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863 ]
73333 Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863 ]
11783 Apaf1; apoptotic peptidase activating factor 1 [KO:K02084 ]
78330 Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944 ]
54405 Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945 ]
17991 Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946 ]
66091 Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947 ]
17992 Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948 ]
407790 Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948 ]
68202 Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949 ]
67130 Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950 ]
66416 Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951 ]
68375 Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952 ]
66108 Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953 ]
67273 Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954 ]
70316 Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955 ]
102634451 Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955 ]
69875 Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956 ]
66414 Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352 ]
67184 Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353 ]
68198 Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958 ]
66495 Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959 ]
68194 Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960 ]
66046 Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961 ]
230075 Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962 ]
66916 Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963 ]
67264 Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964 ]
66218 Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965 ]
68342 Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966 ]
104130 Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351 ]
17993 Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937 ]
595136 Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938 ]
407785 Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939 ]
623286 Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939 ]
66377 Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967 ]
68197 Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968 ]
66945 Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234 ] [EC:1.3.5.1 ]
67680 Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235 ] [EC:1.3.5.1 ]
66052 Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236 ]
66925 Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237 ]
66694 Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411 ] [EC:7.1.1.8 ]
22273 Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414 ]
67003 Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415 ]
66576 Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416 ]
67530 Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417 ]
22272 Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418 ]
66152 Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419 ]
66594 Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420 ]
17710 COX3; cytochrome c oxidase subunit III [KO:K02262 ]
17709 COX2; cytochrome c oxidase subunit II [KO:K02261 ]
12857 Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263 ]
84682 Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263 ]
12858 Cox5a; cytochrome c oxidase subunit 5A [KO:K02264 ]
12859 Cox5b; cytochrome c oxidase subunit 5B [KO:K02265 ]
12861 Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266 ]
12862 Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266 ]
110323 Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267 ]
12864 Cox6c; cytochrome c oxidase subunit 6C [KO:K02268 ]
12866 Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270 ]
12865 Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270 ]
20463 Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270 ]
66142 Cox7b; cytochrome c oxidase subunit 7B [KO:K02271 ]
78174 Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271 ]
12867 Cox7c; cytochrome c oxidase subunit 7C [KO:K02272 ]
12868 Cox8a; cytochrome c oxidase subunit 8A [KO:K02273 ]
12869 Cox8b; cytochrome c oxidase subunit 8B [KO:K02273 ]
75483 Cox8c; cytochrome c oxidase subunit 8C [KO:K02273 ]
11946 Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132 ]
11949 Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136 ]
66043 Atp5f1d; ATP synthase F1 subunit delta [KO:K02134 ]
67126 Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135 ]
11950 Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127 ]
11951 Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128 ]
67942 Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128 ]
228033 Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128 ]
71679 Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138 ]
28080 Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137 ]
11957 Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131 ]
19181 Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061 ]
19179 Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062 ]
23996 Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063 ]
67089 Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064 ]
19182 Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065 ]
19184 Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066 ]
21762 Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028 ]
70247 Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032 ]
22123 Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033 ]
67151 Psmd9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [KO:K06693 ]
66997 Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035 ]
69077 Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036 ]
66413 Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037 ]
17463 Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038 ]
23997 Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039 ]
19185 Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029 ]
59029 Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030 ]
57296 Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031 ]
56436 Adrm1; adhesion regulating molecule 1 26S proteasome ubiquitin receptor [KO:K06691 ]
20422 Sem1; SEM1, 26S proteasome complex subunit [KO:K10881 ]
230558 C8a; complement component 8, alpha polypeptide [KO:K03997 ]
110382 C8b; complement component 8, beta polypeptide [KO:K03998 ]
69379 C8g; complement component 8, gamma polypeptide [KO:K03999 ]
12259 C1qa; complement component 1, q subcomponent, alpha polypeptide [KO:K03986 ]
12260 C1qb; complement component 1, q subcomponent, beta polypeptide [KO:K03987 ]
12262 C1qc; complement component 1, q subcomponent, C chain [KO:K03988 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
13058 Cybb; cytochrome b-245, beta polypeptide [KO:K21421 ] [EC:1.-.-.-]
13057 Cyba; cytochrome b-245, alpha polypeptide [KO:K08009 ]
12912 Creb1; cAMP responsive element binding protein 1 [KO:K05870 ]
11909 Atf2; activating transcription factor 2 [KO:K04450 ]
12913 Creb3; cAMP responsive element binding protein 3 [KO:K09048 ]
26427 Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048 ]
208647 Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048 ]
208677 Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048 ]
78284 Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048 ]
231991 Creb5; cAMP responsive element binding protein 5 [KO:K09047 ]
12915 Atf6b; activating transcription factor 6 beta [KO:K09049 ]
13001 Csnk2b; casein kinase 2, beta polypeptide [KO:K03115 ]
Compound
Reference
Authors
Saa P, Harris DA, Cervenakova L
Title
Mechanisms of prion-induced neurodegeneration.
Journal
Reference
Authors
Goold R, McKinnon C, Tabrizi SJ
Title
Prion degradation pathways: Potential for therapeutic intervention.
Journal
Reference
Authors
Soto C, Satani N
Title
The intricate mechanisms of neurodegeneration in prion diseases.
Journal
Reference
Authors
Mays CE, Soto C
Title
The stress of prion disease.
Journal
Reference
Authors
Jones E, Mead S
Title
Genetic risk factors for Creutzfeldt-Jakob disease.
Journal
Reference
Authors
Kovacs GG, Budka H
Title
Prion diseases: from protein to cell pathology.
Journal
Reference
Authors
Campana V, Sarnataro D, Zurzolo C
Title
The highways and byways of prion protein trafficking.
Journal
Reference
Authors
Caughey B, Baron GS
Title
Prions and their partners in crime.
Journal
Reference
Authors
Chiesa R, Harris DA
Title
Prion diseases: what is the neurotoxic molecule?
Journal
Reference
Authors
Fasano C, Campana V, Zurzolo C
Title
Prions: protein only or something more? Overview of potential prion cofactors.
Journal
Reference
Authors
Roucou X, Gains M, LeBlanc AC
Title
Neuroprotective functions of prion protein.
Journal
Reference
Authors
Harris DA
Title
Cellular biology of prion diseases.
Journal
Clin Microbiol Rev 12:429-44 (1999)
Reference
Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
Title
Prion biology relevant to bovine spongiform encephalopathy.
Journal
Reference
Authors
Peggion C, Bertoli A, Sorgato MC
Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
Journal
Reference
Authors
Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
Title
Prion Protein in Glioblastoma Multiforme.
Journal
Reference
Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
Journal
Reference
Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
Journal
Reference
Authors
Song Z, Zhao D, Yang L
Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
Journal
Reference
Authors
Halliday M, Hughes D, Mallucci GR
Title
Fine-tuning PERK signaling for neuroprotection.
Journal
Reference
Authors
Hughes D, Halliday M
Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
Journal
Reference
Authors
Hetz C, Mollereau B
Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
Journal
Reference
Authors
Hughes D, Mallucci GR
Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
Journal
Reference
Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
Journal
Reference
Authors
Ferreiro E, Oliveira CR, Pereira CM
Title
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
Journal
Reference
Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
Title
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
Journal
Reference
Authors
Torres M, Encina G, Soto C, Hetz C
Title
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
Journal
Reference
Authors
Ciechanover A, Kwon YT
Title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
Journal
Reference
Authors
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ
Title
Disease-associated prion protein oligomers inhibit the 26S proteasome.
Journal
Reference
Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
Title
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
Journal
Reference
Authors
Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
Title
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
Journal
Reference
Authors
Zamponi E, Pigino GF
Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
Journal
Reference
Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
Journal
Reference
Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
Title
Understanding the neurospecificity of Prion protein signaling.
Journal
Reference
Authors
Didonna A
Title
Prion protein and its role in signal transduction.
Journal
Reference
Authors
Shah SZA, Zhao D, Hussain T, Yang L
Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
Journal
Reference
Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
Journal
Reference
Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
Title
Notch-1 activation and dendritic atrophy in prion disease.
Journal
Reference
Authors
Dearmond SJ, Bajsarowicz K
Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
Journal
Reference
Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
Journal
Reference
Authors
Aguzzi A, Zhu C
Title
Microglia in prion diseases.
Journal
Reference
Authors
Mabbott NA
Title
The complement system in prion diseases.
Journal
Reference
Authors
Mallucci G, Collinge J
Title
Rational targeting for prion therapeutics.
Journal
Related pathway
mmu04141 Protein processing in endoplasmic reticulum
mmu04610 Complement and coagulation cascades
KO pathway
LinkDB
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