KEGG   PATHWAY: mmu05022
Entry
mmu05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Mus musculus (house mouse)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05022

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
11820  App; amyloid beta precursor protein [KO:K04520]
17762  Mapt; microtubule-associated protein tau [KO:K04380]
20617  Snca; synuclein, alpha [KO:K04528]
230908  Tardbp; TAR DNA binding protein [KO:K23600]
233908  Fus; fused in sarcoma [KO:K13098]
20655  Sod1; superoxide dismutase 1, soluble [KO:K04565] [EC:1.15.1.1]
20239  Atxn2; ataxin 2 [KO:K23625]
233871  Atxn2l; ataxin 2-like [KO:K23625]
15194  Htt; huntingtin [KO:K04533]
20238  Atxn1; ataxin 1 [KO:K23616]
52335  Atxn1l; ataxin 1-like [KO:K23616]
110616  Atxn3; ataxin 3 [KO:K11863] [EC:3.4.22.-]
19122  Prnp; prion protein [KO:K05634]
12669  Chrm1; cholinergic receptor, muscarinic 1, CNS [KO:K04129]
12671  Chrm3; cholinergic receptor, muscarinic 3, cardiac [KO:K04131]
213788  Chrm5; cholinergic receptor, muscarinic 5 [KO:K04133]
20743  Sptbn2; spectrin beta, non-erythrocytic 2 [KO:K23932]
14816  Grm1; glutamate receptor, metabotropic 1 [KO:K04603]
108071  Grm5; glutamate receptor, metabotropic 5 [KO:K04604]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
50873  Prkn; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18803  Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
22065  Trpc3; transient receptor potential cation channel, subfamily C, member 3 [KO:K04966]
18391  Sigmar1; sigma non-opioid intracellular receptor 1 [KO:K20719]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
20190  Ryr1; ryanodine receptor 1, skeletal muscle [KO:K04961]
20191  Ryr2; ryanodine receptor 2, cardiac [KO:K04962]
20192  Ryr3; ryanodine receptor 3 [KO:K04963]
18610  Pdyn; prodynorphin [KO:K15840]
13385  Dlg4; discs large MAGUK scaffold protein 4 [KO:K11828]
14810  Grin1; glutamate receptor, ionotropic, NMDA1 (zeta 1) [KO:K05208]
14811  Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209]
14812  Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210]
14813  Grin2c; glutamate receptor, ionotropic, NMDA2C (epsilon 3) [KO:K05211]
14814  Grin2d; glutamate receptor, ionotropic, NMDA2D (epsilon 4) [KO:K05212]
14799  Gria1; glutamate receptor, ionotropic, AMPA1 (alpha 1) [KO:K05197]
14800  Gria2; glutamate receptor, ionotropic, AMPA2 (alpha 2) [KO:K05198]
53623  Gria3; glutamate receptor, ionotropic, AMPA3 (alpha 3) [KO:K05199]
14802  Gria4; glutamate receptor, ionotropic, AMPA4 (alpha 4) [KO:K05200]
12287  Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
12288  Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
54652  Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853]
12292  Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
20907  Stx1a; syntaxin 1A (brain) [KO:K04560]
11441  Chrna7; cholinergic receptor, nicotinic, alpha polypeptide 7 [KO:K04809]
11937  Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:7.2.2.10]
53313  Atp2a3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:7.2.2.10]
11938  Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:7.2.2.10]
19164  Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
19165  Psen2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
67819  Derl1; Der1-like domain family, member 1 [KO:K11519]
269523  Vcp; valosin containing protein [KO:K13525]
22186  Uba52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
78294  Rps27a; ribosomal protein S27A [KO:K02977]
102631952  Gm5928; predicted gene 5928 [KO:K02977]
22187  Ubb; ubiquitin B [KO:K04551]
22190  Ubc; ubiquitin C [KO:K08770]
26443  Psma6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
19166  Psma2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
26441  Psma4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
26444  Psma7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
73677  Psma8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
26442  Psma5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
26440  Psma1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
19167  Psma3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
19175  Psmb6; proteasome (prosome, macropain) subunit, beta type 6 [KO:K02738] [EC:3.4.25.1]
19177  Psmb7; proteasome (prosome, macropain) subunit, beta type 7 [KO:K02739] [EC:3.4.25.1]
26446  Psmb3; proteasome (prosome, macropain) subunit, beta type 3 [KO:K02735] [EC:3.4.25.1]
26445  Psmb2; proteasome (prosome, macropain) subunit, beta type 2 [KO:K02734] [EC:3.4.25.1]
19173  Psmb5; proteasome (prosome, macropain) subunit, beta type 5 [KO:K02737] [EC:3.4.25.1]
19170  Psmb1; proteasome (prosome, macropain) subunit, beta type 1 [KO:K02732] [EC:3.4.25.1]
19172  Psmb4; proteasome (prosome, macropain) subunit, beta type 4 [KO:K02736] [EC:3.4.25.1]
19181  Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061]
19179  Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
23996  Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
67089  Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
19182  Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065]
19184  Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066]
21762  Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
70247  Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
22123  Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
67151  Psmd9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [KO:K06693]
66997  Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
69077  Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
66413  Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
17463  Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
23997  Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
19185  Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
59029  Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
57296  Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
56436  Adrm1; adhesion regulating molecule 1 26S proteasome ubiquitin receptor [KO:K06691]
20422  Sem1; SEM1, 26S proteasome complex subunit [KO:K10881]
22223  Uchl1; ubiquitin carboxy-terminal hydrolase L1 [KO:K05611] [EC:3.4.19.12]
22202  Uba1y; ubiquitin-activating enzyme, Chr Y [KO:K03178] [EC:6.2.1.45]
22201  Uba1; ubiquitin-like modifier activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
74153  Uba7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
22195  Ube2l3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:2.3.2.23]
100040961  Gm10145; predicted gene 10145 [KO:K04552] [EC:2.3.2.23]
108167877  Gm11954; predicted gene 11954 [KO:K04552] [EC:2.3.2.23]
100502680  Gm10015; predicted gene 10015 [KO:K04552] [EC:2.3.2.23]
56791  Ube2l6; ubiquitin-conjugating enzyme E2L 6 [KO:K04553] [EC:2.3.2.23]
140499  Ube2j2; ubiquitin-conjugating enzyme E2J 2 [KO:K04554] [EC:2.3.2.23]
56228  Ube2j1; ubiquitin-conjugating enzyme E2J 1 [KO:K10578] [EC:2.3.2.23]
22213  Ube2g2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:2.3.2.23]
67128  Ube2g1; ubiquitin-conjugating enzyme E2G 1 [KO:K10575] [EC:2.3.2.23]
14763  Gpr37; G protein-coupled receptor 37 [KO:K04243]
18951  Septin5; septin 5 [KO:K04557]
67847  Sncaip; synuclein, alpha interacting protein (synphilin) [KO:K04558]
14828  Hspa5; heat shock protein 5 [KO:K09490] [EC:3.6.4.10]
56491  Vapb; vesicle-associated membrane protein, associated protein B and C [KO:K10707]
226641  Atf6; activating transcription factor 6 [KO:K09054]
13198  Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
22433  Xbp1; X-box binding protein 1 [KO:K09027]
78943  Ern1; endoplasmic reticulum to nucleus signalling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26400  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
12364  Casp12; caspase 12 [KO:K04741] [EC:3.4.22.-]
269881  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
13666  Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
13665  Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
11911  Atf4; activating transcription factor 4 [KO:K04374]
13162  Slc6a3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [KO:K05036]
68943  Pink1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
17711  CYTB; cytochrome b [KO:K00412]
66445  Cyc1; cytochrome c-1 [KO:K00413]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
53333  Tomm40; translocase of outer mitochondrial membrane 40 [KO:K11518]
641376  Tomm40l; translocase of outer mitochondrial membrane 40-like [KO:K11518]
215999  Mcu; mitochondrial calcium uniporter [KO:K20858]
12313  Calm1; calmodulin 1 [KO:K02183]
80796  Calm4; calmodulin 4 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
70405  Calml3; calmodulin-like 3 [KO:K02183]
494124  Calm5; calmodulin 5 [KO:K02183]
75600  Calml4; calmodulin-like 4 [KO:K02183]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
14103  Fasl; Fas ligand [KO:K04389]
14102  Fas; Fas cell surface death receptor [KO:K04390]
14082  Fadd; Fas associated via death domain [KO:K02373]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12028  Bax; BCL2-associated X protein [KO:K02159]
12018  Bak1; BCL2-antagonist/killer 1 [KO:K14021]
66725  Lrrk2; leucine-rich repeat kinase 2 [KO:K08844] [EC:2.7.11.1]
64704  Htra2; HtrA serine peptidase 2 [KO:K08669] [EC:3.4.21.108]
68015  Trap1; TNF receptor-associated protein 1 [KO:K09488]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
105675  Ppif; peptidylprolyl isomerase F (cyclophilin F) [KO:K09565] [EC:5.2.1.8]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
215114  Hip1; huntingtin interacting protein 1 [KO:K04559]
73916  Ift57; intraflagellar transport 57 [KO:K04638]
15108  Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
67738  Ppid; peptidylprolyl isomerase D (cyclophilin D) [KO:K05864] [EC:5.2.1.8]
57320  Park7; Parkinson disease (autosomal recessive, early onset) 7 [KO:K05687] [EC:3.5.1.124]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
67414  Mfn1; mitofusin 1 [KO:K21356] [EC:3.6.5.-]
170731  Mfn2; mitofusin 2 [KO:K06030] [EC:3.6.5.-]
71648  Optn; optineurin [KO:K19946]
18412  Sqstm1; sequestosome 1 [KO:K14381]
66734  Map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435]
67443  Map1lc3b; microtubule-associated protein 1 light chain 3 beta [KO:K10435]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
21353  Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650]
218460  Wdr41; WD repeat domain 41 [KO:K23610]
237782  Smcr8; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) [KO:K23611]
73205  C9orf72; C9orf72, member of C9orf72-SMCR8 complex [KO:K23609]
17274  Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
67790  Rab39b; RAB39B, member RAS oncogene family [KO:K07925]
19324  Rab1a; RAB1A, member RAS oncogene family [KO:K07874]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
22241  Ulk1; unc-51 like kinase 1 [KO:K21357] [EC:2.7.11.1]
29869  Ulk2; unc-51 like kinase 2 [KO:K08269] [EC:2.7.11.1]
68118  Atg101; autophagy related 101 [KO:K19730]
51897  Atg13; autophagy related 13 [KO:K08331]
12421  Rb1cc1; RB1-inducible coiled-coil 1 [KO:K17589]
228361  Ambra1; autophagy/beclin 1 regulator 1 [KO:K17985]
56208  Becn1; beclin 1, autophagy related [KO:K08334]
75669  Pik3r4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100504663  Atg14; autophagy related 14 [KO:K17889]
641340  Nrbf2; nuclear receptor binding factor 2 [KO:K21246]
225326  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
329015  Atg2a; autophagy related 2A [KO:K17906]
76559  Atg2b; autophagy related 2B [KO:K17906]
52639  Wipi1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
74781  Wipi2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
217695  Zfyve1; zinc finger, FYVE domain containing 1 [KO:K17603]
74018  Als2; alsin Rho guanine nucleotide exchange factor [KO:K04575]
271457  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
68942  Chmp2b; charged multivesicular body protein 2B [KO:K12192]
103199  Fig4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
214585  Spg11; SPG11, spatacsin vesicle trafficking associated [KO:K19026]
21926  Tnf; tumor necrosis factor [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
21938  Tnfrsf1b; tumor necrosis factor receptor superfamily, member 1b [KO:K05141]
13163  Daxx; Fas death domain-associated protein [KO:K02308]
26397  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26399  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
12460  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
14775  Gpx1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
14776  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
14778  Gpx3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
14780  Gpx5; glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
67305  Gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
75512  Gpx6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
69590  Gpx8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
12359  Cat; catalase [KO:K03781] [EC:1.11.1.6]
19132  Prph; peripherin [KO:K07607]
18039  Nefl; neurofilament, light polypeptide [KO:K04572]
18040  Nefm; neurofilament, medium polypeptide [KO:K04573]
380684  Nefh; neurofilament, heavy polypeptide [KO:K04574]
16572  Kif5a; kinesin family member 5A [KO:K10396]
16573  Kif5b; kinesin family member 5B [KO:K10396]
16574  Kif5c; kinesin family member 5C [KO:K10396]
16593  Klc1; kinesin light chain 1 [KO:K10407]
16594  Klc2; kinesin light chain 2 [KO:K10407]
232943  Klc3; kinesin light chain 3 [KO:K10407]
74764  Klc4; kinesin light chain 4 [KO:K10407]
22145  Tuba4a; tubulin, alpha 4A [KO:K07374]
22144  Tuba3a; tubulin, alpha 3A [KO:K07374]
22142  Tuba1a; tubulin, alpha 1A [KO:K07374]
22146  Tuba1c; tubulin, alpha 1C [KO:K07374]
22147  Tuba3b; tubulin, alpha 3B [KO:K07374]
22143  Tuba1b; tubulin, alpha 1B [KO:K07374]
53857  Tuba8; tubulin, alpha 8 [KO:K07374]
238463  Tubal3; tubulin, alpha-like 3 [KO:K07374]
227613  Tubb4b; tubulin, beta 4B class IVB [KO:K07375]
22151  Tubb2a; tubulin, beta 2A class IIA [KO:K07375]
22152  Tubb3; tubulin, beta 3 class III [KO:K07375]
22153  Tubb4a; tubulin, beta 4A class IVA [KO:K07375]
67951  Tubb6; tubulin, beta 6 class V [KO:K07375]
22154  Tubb5; tubulin, beta 5 class I [KO:K07375]
545486  Tubb1; tubulin, beta 1 class VI [KO:K07375]
73710  Tubb2b; tubulin, beta 2B class IIB [KO:K07375]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
12995  Csnk2a1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
13000  Csnk2a2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
13001  Csnk2b; casein kinase 2, beta polypeptide [KO:K03115]
12064  Bdnf; brain derived neurotrophic factor [KO:K04355]
13191  Dctn1; dynactin 1 [KO:K04648]
69654  Dctn2; dynactin 2 [KO:K10424]
53598  Dctn3; dynactin 3 [KO:K10425]
67665  Dctn4; dynactin 4 [KO:K10426]
59288  Dctn5; dynactin 5 [KO:K10427]
22428  Dctn6; dynactin 6 [KO:K10428]
54130  Actr1a; ARP1 actin-related protein 1A, centractin alpha [KO:K16575]
226977  Actr1b; ARP1 actin-related protein 1B, centractin beta [KO:K16575]
56444  Actr10; ARP10 actin-related protein 10 [KO:K16576]
15114  Hap1; huntingtin-associated protein 1 [KO:K04647]
110084  Dnah1; dynein, axonemal, heavy chain 1 [KO:K10408]
381917  Dnah3; dynein, axonemal, heavy chain 3 [KO:K10408]
327954  Dnah2; dynein, axonemal, heavy chain 2 [KO:K10408]
227058  Dnah7b; dynein, axonemal, heavy chain 7B [KO:K10408]
110082  Dnah5; dynein, axonemal, heavy chain 5 [KO:K10408]
330355  Dnah6; dynein, axonemal, heavy chain 6 [KO:K10408]
237806  Dnah9; dynein, axonemal, heavy chain 9 [KO:K10408]
13411  Dnah11; dynein, axonemal, heavy chain 11 [KO:K10408]
110083  Dnah12; dynein, axonemal, heavy chain 12 [KO:K10408]
13417  Dnah8; dynein, axonemal, heavy chain 8 [KO:K10408]
627872  Dnah7a; dynein, axonemal, heavy chain 7A [KO:K10408]
56087  Dnah10; dynein, axonemal, heavy chain 10 [KO:K10408]
69926  Dnah17; dynein, axonemal, heavy chain 17 [KO:K10408]
240960  Dnah14; dynein, axonemal, heavy chain 14 [KO:K10408]
100101919  Dnah7c; dynein, axonemal, heavy chain 7C [KO:K10408]
75563  Dnali1; dynein, axonemal, light intermediate polypeptide 1 [KO:K10410]
68922  Dnai1; dynein axonemal intermediate chain 1 [KO:K10409]
432611  Dnai2; dynein axonemal intermediate chain 2 [KO:K11143]
105000  Dnal1; dynein, axonemal, light chain 1 [KO:K10411]
54152  Dnal4; dynein, axonemal, light chain 4 [KO:K10412]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12333  Capn1; calpain 1 [KO:K01367] [EC:3.4.22.52]
12334  Capn2; calpain 2 [KO:K03853] [EC:3.4.22.53]
12569  Cdk5r1; cyclin dependent kinase 5, regulatory subunit 1 [KO:K11716]
12568  Cdk5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
12369  Casp7; caspase 7 [KO:K04397] [EC:3.4.22.60]
13380  Dkk1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
56811  Dkk2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
234130  Dkk4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
22408  Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22413  Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
20890  Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
22423  Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
216795  Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
22412  Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22410  Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22409  Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22411  Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
93735  Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
14362  Fzd1; frizzled class receptor 1 [KO:K02432]
14369  Fzd7; frizzled class receptor 7 [KO:K02432]
57265  Fzd2; frizzled class receptor 2 [KO:K02235]
14365  Fzd3; frizzled class receptor 3 [KO:K02329]
14366  Fzd4; frizzled class receptor 4 [KO:K02354]
14367  Fzd5; frizzled class receptor 5 [KO:K02375]
14370  Fzd8; frizzled class receptor 8 [KO:K02375]
14368  Fzd6; frizzled class receptor 6 [KO:K02376]
93897  Fzd10; frizzled class receptor 10 [KO:K02842]
14371  Fzd9; frizzled class receptor 9 [KO:K02842]
16973  Lrp5; low density lipoprotein receptor-related protein 5 [KO:K03068]
16974  Lrp6; low density lipoprotein receptor-related protein 6 [KO:K03068]
27373  Csnk1e; casein kinase 1, epsilon [KO:K08960] [EC:2.7.11.1]
13544  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
13542  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
13543  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
14296  Frat1; frequently rearranged in advanced T cell lymphomas [KO:K03069]
27412  Peg12; paternally expressed 12 [KO:K03069]
212398  Frat2; frequently rearranged in advanced T cell lymphomas 2 [KO:K03096]
12005  Axin1; axin 1 [KO:K02157]
12006  Axin2; axin 2 [KO:K04385]
11789  Apc; APC, WNT signaling pathway regulator [KO:K02085]
23805  Apc2; APC regulator of WNT signaling pathway 2 [KO:K02085]
12387  Ctnnb1; catenin beta 1 [KO:K02105]
93687  Csnk1a1; casein kinase 1, alpha 1 [KO:K08957] [EC:2.7.11.1]
11596  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
237038  Nox1; NADPH oxidase 1 [KO:K08008]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
50490  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
19225  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
16193  Il6; interleukin 6 [KO:K05405]
16175  Il1a; interleukin 1 alpha [KO:K04383]
16176  Il1b; interleukin 1 beta [KO:K04519]
12977  Csf1; colony stimulating factor 1 (macrophage) [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
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Reference
PMID:30743990
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Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
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Related
pathway
mmu00190  Oxidative phosphorylation
mmu03050  Proteasome
mmu04020  Calcium signaling pathway
mmu04120  Ubiquitin mediated proteolysis
mmu04137  Mitophagy - animal
mmu04140  Autophagy - animal
mmu04141  Protein processing in endoplasmic reticulum
mmu04142  Lysosome
mmu04210  Apoptosis
mmu04310  Wnt signaling pathway
mmu04724  Glutamatergic synapse
mmu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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