Entry
Name
Hepatitis C - Mus musculus (house mouse)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
16835 Ldlr; low density lipoprotein receptor [KO:K12473 ]
20778 Scarb1; scavenger receptor class B, member 1 [KO:K13885 ]
24014 Rnasel; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [KO:K01165 ]
228607 Mavs; mitochondrial antiviral signaling protein [KO:K12648 ]
22031 Traf3; TNF receptor-associated factor 3 [KO:K03174 ]
106759 Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
18035 Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
15945 Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
15467 Eif2ak1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194 ] [EC:2.7.11.1 ]
19106 Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195 ] [EC:2.7.11.1 ]
13666 Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860 ] [EC:2.7.11.1 ]
27103 Eif2ak4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196 ] [EC:2.7.11.1 ]
112419 Ifit1bl2; interferon induced protein with tetratricopeptide repeats 1B like 2 [KO:K14217 ]
15957 Ifit1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217 ]
667373 Ifit1bl1; interferon induced protein with tetratricpeptide repeats 1B like 1 [KO:K14217 ]
16341 Eif3e; eukaryotic translation initiation factor 3, subunit E [KO:K03250 ]
13665 Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237 ]
20848 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
12702 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
15975 Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130 ]
15976 Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131 ]
20846 Stat1; signal transducer and activator of transcription 1 [KO:K11220 ]
20847 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
58185 Rsad2; radical S-adenosyl methionine domain containing 2 [KO:K15045 ]
51792 Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456 ]
73699 Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456 ]
52432 Ppp2r2d; protein phosphatase 2, regulatory subunit B, delta [KO:K04354 ]
72930 Ppp2r2b; protein phosphatase 2, regulatory subunit B, beta [KO:K04354 ]
269643 Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354 ]
71978 Ppp2r2a; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354 ]
19052 Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
19053 Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
56469 Pias1; protein inhibitor of activated STAT 1 [KO:K04706 ] [EC:2.3.2.-]
14784 Grb2; growth factor receptor bound protein 2 [KO:K04364 ]
20662 Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
20663 Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
22631 Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [KO:K16197 ]
54401 Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [KO:K16197 ]
22630 Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197 ]
22627 Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630 ]
22629 Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [KO:K16198 ]
22628 Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [KO:K16198 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
12015 Bad; BCL2-associated agonist of cell death [KO:K02158 ]
12575 Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
19645 Rb1; RB transcriptional corepressor 1 [KO:K06618 ]
21937 Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158 ]
71609 Tradd; TNFRSF1A-associated via death domain [KO:K03171 ]
14082 Fadd; Fas associated via death domain [KO:K02373 ]
12633 Cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724 ]
12122 Bid; BH3 interacting domain death agonist [KO:K04726 ]
11783 Apaf1; apoptotic peptidase activating factor 1 [KO:K02084 ]
19192 Psme3; proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [KO:K06698 ]
19013 Ppara; peroxisome proliferator activated receptor alpha [KO:K07294 ]
22259 Nr1h3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
Journal
Reference
Authors
Yamauchi Y, Helenius A
Title
Virus entry at a glance.
Journal
Reference
Authors
Feneant L, Levy S, Cocquerel L
Title
CD81 and hepatitis C virus (HCV) infection.
Journal
Reference
Authors
Dubuisson J, Helle F, Cocquerel L
Title
Early steps of the hepatitis C virus life cycle.
Journal
Reference
Authors
Liang TJ, Ghany MG
Title
Current and future therapies for hepatitis C virus infection.
Journal
Reference
Authors
Scheel TK, Rice CM
Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Journal
Reference
Authors
Holmes JA, Thompson AJ
Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
Journal
Reference
Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Journal
Reference
Authors
Horner SM, Gale M Jr
Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal
Reference
Authors
Lemon SM
Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
Journal
Reference
Authors
Horner SM, Gale M Jr
Title
Regulation of hepatic innate immunity by hepatitis C virus.
Journal
Reference
Authors
Ortega-Prieto AM, Dorner M
Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
Journal
Reference
Authors
Yang DR, Zhu HZ
Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
Journal
Reference
Authors
Gale M Jr, Foy EM
Title
Evasion of intracellular host defence by hepatitis C virus.
Journal
Reference
Authors
Bode JG, Brenndorfer ED, Haussinger D
Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
Journal
Reference
Authors
Panteva M, Korkaya H, Jameel S
Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal
Reference
Authors
Pang R, Tse E, Poon RT
Title
Molecular pathways in hepatocellular carcinoma.
Journal
Reference
Authors
Macdonald A, Harris M
Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
Journal
Reference
Authors
He Y, Staschke KA, Tan SL
Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Journal
Reference
Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
Journal
Reference
Authors
Hassan M, Ghozlan H, Abdel-Kader O
Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
Journal
Reference
Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
Journal
Reference
Authors
Yamanaka T, Uchida M, Doi T
Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
Journal
Reference
Authors
Lim EJ, Chin R, Angus PW, Torresi J
Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
Journal
Reference
Authors
Fischer R, Baumert T, Blum HE
Title
Hepatitis C virus infection and apoptosis.
Journal
Reference
Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
Journal
Reference
Authors
Koike K
Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Journal
Reference
Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Journal
Reference
Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
Title
Viral hepatocarcinogenesis: from infection to cancer.
Journal
Related pathway
mmu04620 Toll-like receptor signaling pathway
mmu04622 RIG-I-like receptor signaling pathway
KO pathway
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