KEGG   PATHWAY: mmu05164
Entry
mmu05164                    Pathway                                
Name
Influenza A - Mus musculus (house mouse)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmu05164  Influenza A
mmu05164

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
17229  Tpsb2; tryptase beta 2 [KO:K01340] [EC:3.4.21.59]
100503895  Tpsab1; tryptase alpha/beta 1 [KO:K01340] [EC:3.4.21.59]
18815  Plg; plasminogen [KO:K01315] [EC:3.4.21.7]
436522  Try10; trypsin 10 [KO:K01312] [EC:3.4.21.4]
22072  Prss2; serine protease 2 [KO:K01312] [EC:3.4.21.4]
67373  Prss3b; serine protease 3B [KO:K01312] [EC:3.4.21.4]
103964  Try5; trypsin 5 [KO:K01312] [EC:3.4.21.4]
100040208  Gm2663; predicted gene 2663 [KO:K01312] [EC:3.4.21.4]
100040233  Prss3l; serine protease 3 like [KO:K01312] [EC:3.4.21.4]
22074  Try4; trypsin 4 [KO:K01312] [EC:3.4.21.4]
73626  1810009J06Rik; RIKEN cDNA 1810009J06 gene [KO:K01312] [EC:3.4.21.4]
436523  Prss1l; serine protease 1 (trypsin 1) like [KO:K01312] [EC:3.4.21.4]
22073  Prss3; serine protease 3 [KO:K01312] [EC:3.4.21.4]
114228  Prss1; serine protease 1 (trypsin 1) [KO:K01312] [EC:3.4.21.4]
50528  Tmprss2; transmembrane protease, serine 2 [KO:K09633] [EC:3.4.21.122]
214523  Tmprss4; transmembrane protease, serine 4 [KO:K09635] [EC:3.4.21.-]
231382  Tmprss11d; transmembrane protease, serine 11d [KO:K09641] [EC:3.4.21.-]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
246730  Oas1a; 2'-5' oligoadenylate synthetase 1A [KO:K14216] [EC:2.7.7.84]
246728  Oas2; 2'-5' oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
246727  Oas3; 2'-5' oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
23961  Oas1b; 2'-5' oligoadenylate synthetase 1B [KO:K14216] [EC:2.7.7.84]
23960  Oas1g; 2'-5' oligoadenylate synthetase 1G [KO:K14216] [EC:2.7.7.84]
24014  Rnasel; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [KO:K01165]
81489  Dnajb1; DnaJ heat shock protein family (Hsp40) member B1 [KO:K09507]
100037258  Dnajc3; DnaJ heat shock protein family (Hsp40) member C3 [KO:K09523]
19106  Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
13665  Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
217069  Trim25; tripartite motif-containing 25 [KO:K10652] [EC:2.3.2.27]
230073  Rigi; RNA sensor RIG-I [KO:K12646] [EC:5.6.2.6]
71586  Ifih1; interferon induced with helicase C domain 1 [KO:K12647] [EC:5.6.2.6]
270151  Nlrx1; NLR family member X1 [KO:K12653]
228607  Mavs; mitochondrial antiviral signaling protein [KO:K12648]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18036  Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
76815  Calcoco2; calcium binding and coiled-coil domain 2 [KO:K21348]
142980  Tlr3; toll-like receptor 3 [KO:K05401]
106759  Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842]
22031  Traf3; TNF receptor-associated factor 3 [KO:K03174]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
56489  Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
12914  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
21898  Tlr4; toll-like receptor 4 [KO:K10160]
170743  Tlr7; toll-like receptor 7 [KO:K05404]
17874  Myd88; myeloid differentiation primary response gene 88 [KO:K04729]
266632  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
54123  Irf7; interferon regulatory factor 7 [KO:K09447]
16175  Il1a; interleukin 1 alpha [KO:K04383]
16176  Il1b; interleukin 1 beta [KO:K04519]
16193  Il6; interleukin 6 [KO:K05405]
16159  Il12a; interleukin 12a [KO:K05406]
16160  Il12b; interleukin 12b [KO:K05425]
21926  Tnf; tumor necrosis factor [KO:K03156]
20296  Ccl2; C-C motif chemokine ligand 2 [KO:K14624]
20293  Ccl12; C-C motif chemokine ligand 12 [KO:K14624]
20304  Ccl5; C-C motif chemokine ligand 5 [KO:K12499]
15945  Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671]
15894  Icam1; intercellular adhesion molecule 1 [KO:K06490]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
230396  Ifna13; interferon alpha 13 [KO:K05414]
404549  Ifna14; interferon alpha 14 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
242517  Ifna15; interferon alpha 15 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
15977  Ifnb1; interferon beta 1, fibroblast [KO:K05415]
15975  Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976  Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
54721  Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
12702  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
20846  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
16391  Irf9; interferon regulatory factor 9 [KO:K04693]
17858  Mx2; MX dynamin-like GTPase 2 [KO:K14754]
17857  Mx1; MX dynamin-like GTPase 1 [KO:K14754]
56417  Adar; adenosine deaminase, RNA-specific [KO:K12968] [EC:3.5.4.37]
18854  Pml; promyelocytic leukemia [KO:K10054] [EC:2.3.2.-]
15978  Ifng; interferon gamma [KO:K04687]
15979  Ifngr1; interferon gamma receptor 1 [KO:K05132]
15980  Ifngr2; interferon gamma receptor 2 [KO:K05133]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
12265  Ciita; class II transactivator [KO:K08060] [EC:2.7.11.1]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404  H2-Ea; histocompatibility 2, class II antigen E alpha [KO:K06752]
381091  H2-Eb2; histocompatibility 2, class II antigen E beta2 [KO:K06752]
216799  Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800]
66824  Pycard; PYD and CARD domain containing [KO:K12799]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
16173  Il18; interleukin 18 [KO:K05482]
77125  Il33; interleukin 33 [KO:K12967]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
12445  Ccnd3; cyclin D3 [KO:K10152]
12567  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
12571  Cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
22035  Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
21933  Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
14103  Fasl; Fas ligand [KO:K04389]
14102  Fas; Fas cell surface death receptor [KO:K04390]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
71609  Tradd; TNFRSF1A-associated via death domain [KO:K03171]
14082  Fadd; Fas associated via death domain [KO:K02373]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12028  Bax; BCL2-associated X protein [KO:K02159]
12018  Bak1; BCL2-antagonist/killer 1 [KO:K14021]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
54188  Cpsf4; cleavage and polyadenylation specific factor 4 [KO:K14404]
54196  Pabpn1; poly(A) binding protein, nuclear 1 [KO:K14396]
382035  Pabpn1l; poly(A)binding protein nuclear 1-like [KO:K14396]
53319  Nxf1; nuclear RNA export factor 1 [KO:K14284]
170722  Nxf7; nuclear RNA export factor 7 [KO:K14284]
83454  Nxf2; nuclear RNA export factor 2 [KO:K14284]
245610  Nxf3; nuclear RNA export factor 3 [KO:K14284]
56488  Nxt1; NTF2-related export protein 1 [KO:K14285]
237082  Nxt2; nuclear transport factor 2-like export factor 2 [KO:K14285]
232989  Hnrnpul1; heterogeneous nuclear ribonucleoprotein U-like 1 [KO:K15047]
66679  Rae1; ribonucleic acid export 1 [KO:K14298]
269966  Nup98; nucleoporin 98 [KO:K14297]
58185  Rsad2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
110196  Fdps; farnesyl diphosphate synthetase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
11465  Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
11461  Actb; actin, beta [KO:K05692]
53869  Rab11a; RAB11A, member RAS oncogene family [KO:K07904]
19326  Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
103573  Xpo1; exportin 1 [KO:K14290]
16646  Kpna1; karyopherin subunit alpha 1 [KO:K23940]
16647  Kpna2; karyopherin subunit alpha 2 [KO:K15043]
381686  Kpna7; karyopherin subunit alpha 7 [KO:K15043]
16650  Kpna6; karyopherin subunit alpha 6 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
mmu00900  Terpenoid backbone biosynthesis
mmu03013  Nucleocytoplasmic transport
mmu03015  mRNA surveillance pathway
mmu04010  MAPK signaling pathway
mmu04110  Cell cycle
mmu04144  Endocytosis
mmu04210  Apoptosis
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04622  RIG-I-like receptor signaling pathway
mmu04630  JAK-STAT signaling pathway
mmu05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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